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Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium. / Phelan, Catherine M; Tsai, Ya-Yu; Goode, Ellen L; Vierkant, Robert A; Fridley, Brooke L; Beesley, Jonathan; Chen, Xiao Qing; Webb, Penelope M; Chanock, Stephen; Cramer, Daniel W; Moysich, Kirsten; Edwards, Robert P; Chang-Claude, Jenny; Garcia-Closas, Montserrat; Yang, Hannah; Wang-Gohrke, Shan; Hein, Rebecca; Green, Adele C; Lissowska, Jolanta; Carney, Michael E; Lurie, Galina; Wilkens, Lynne R; Ness, Roberta B; Pearce, Celeste Leigh; Wu, Anna H; Van Den Berg, David J; Stram, Daniel O; Terry, Kathryn L; Whiteman, David C; Whittemore, Alice S; DiCioccio, Richard A; McGuire, Valerie; Doherty, Jennifer A; Rossing, Mary Anne; Anton-Culver, Hoda; Ziogas, Argyrios; Hogdall, Claus; Hogdall, Estrid; Krüger Kjaer, Susanne; Blaakaer, Jan; Quaye, Lydia; Ramus, Susan J; Jacobs, Ian; Song, Honglin; Pharoah, Paul D P; Iversen, Edwin S; Marks, Jeffrey R; Pike, Malcolm C; Gayther, Simon A; Cunningham, Julie M; Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer).
I:
Cancer Epidemiology, Biomarkers & Prevention, Bind 19, Nr. 2, 01.02.2010, s. 600-4.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Phelan, CM, Tsai, Y-Y, Goode, EL, Vierkant, RA, Fridley, BL, Beesley, J, Chen, XQ, Webb, PM, Chanock, S, Cramer, DW, Moysich, K, Edwards, RP, Chang-Claude, J, Garcia-Closas, M, Yang, H, Wang-Gohrke, S, Hein, R, Green, AC, Lissowska, J, Carney, ME, Lurie, G, Wilkens, LR, Ness, RB, Pearce, CL, Wu, AH, Van Den Berg, DJ, Stram, DO, Terry, KL, Whiteman, DC, Whittemore, AS, DiCioccio, RA, McGuire, V, Doherty, JA, Rossing, MA, Anton-Culver, H, Ziogas, A
, Hogdall, C, Hogdall, E, Krüger Kjaer, S, Blaakaer, J, Quaye, L, Ramus, SJ, Jacobs, I, Song, H, Pharoah, PDP, Iversen, ES, Marks, JR, Pike, MC, Gayther, SA, Cunningham, JM & Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer) 2010, '
Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium',
Cancer Epidemiology, Biomarkers & Prevention, bind 19, nr. 2, s. 600-4.
https://doi.org/10.1158/1055-9965.EPI-09-0861APA
Phelan, C. M., Tsai, Y-Y., Goode, E. L., Vierkant, R. A., Fridley, B. L., Beesley, J., Chen, X. Q., Webb, P. M., Chanock, S., Cramer, D. W., Moysich, K., Edwards, R. P., Chang-Claude, J., Garcia-Closas, M., Yang, H., Wang-Gohrke, S., Hein, R., Green, A. C., Lissowska, J., ... Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer) (2010).
Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium.
Cancer Epidemiology, Biomarkers & Prevention,
19(2), 600-4.
https://doi.org/10.1158/1055-9965.EPI-09-0861Vancouver
Phelan CM, Tsai Y-Y, Goode EL, Vierkant RA, Fridley BL, Beesley J o.a.
Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium.
Cancer Epidemiology, Biomarkers & Prevention. 2010 feb. 1;19(2):600-4.
https://doi.org/10.1158/1055-9965.EPI-09-0861Author
Phelan, Catherine M ; Tsai, Ya-Yu ; Goode, Ellen L ; Vierkant, Robert A ; Fridley, Brooke L ; Beesley, Jonathan ; Chen, Xiao Qing ; Webb, Penelope M ; Chanock, Stephen ; Cramer, Daniel W ; Moysich, Kirsten ; Edwards, Robert P ; Chang-Claude, Jenny ; Garcia-Closas, Montserrat ; Yang, Hannah ; Wang-Gohrke, Shan ; Hein, Rebecca ; Green, Adele C ; Lissowska, Jolanta ; Carney, Michael E ; Lurie, Galina ; Wilkens, Lynne R ; Ness, Roberta B ; Pearce, Celeste Leigh ; Wu, Anna H ; Van Den Berg, David J ; Stram, Daniel O ; Terry, Kathryn L ; Whiteman, David C ; Whittemore, Alice S ; DiCioccio, Richard A ; McGuire, Valerie ; Doherty, Jennifer A ; Rossing, Mary Anne ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Hogdall, Claus ; Hogdall, Estrid ; Krüger Kjaer, Susanne ; Blaakaer, Jan ; Quaye, Lydia ; Ramus, Susan J ; Jacobs, Ian ; Song, Honglin ; Pharoah, Paul D P ; Iversen, Edwin S ; Marks, Jeffrey R ; Pike, Malcolm C ; Gayther, Simon A ; Cunningham, Julie M ; Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer). / Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium. I: Cancer Epidemiology, Biomarkers & Prevention. 2010 ; Bind 19, Nr. 2. s. 600-4.
Bibtex
@article{e1b105771b7842ce90ea33932cc3fc07,
title = "Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium",
abstract = "Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for heterogeneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.",
author = "Phelan, {Catherine M} and Ya-Yu Tsai and Goode, {Ellen L} and Vierkant, {Robert A} and Fridley, {Brooke L} and Jonathan Beesley and Chen, {Xiao Qing} and Webb, {Penelope M} and Stephen Chanock and Cramer, {Daniel W} and Kirsten Moysich and Edwards, {Robert P} and Jenny Chang-Claude and Montserrat Garcia-Closas and Hannah Yang and Shan Wang-Gohrke and Rebecca Hein and Green, {Adele C} and Jolanta Lissowska and Carney, {Michael E} and Galina Lurie and Wilkens, {Lynne R} and Ness, {Roberta B} and Pearce, {Celeste Leigh} and Wu, {Anna H} and {Van Den Berg}, {David J} and Stram, {Daniel O} and Terry, {Kathryn L} and Whiteman, {David C} and Whittemore, {Alice S} and DiCioccio, {Richard A} and Valerie McGuire and Doherty, {Jennifer A} and Rossing, {Mary Anne} and Hoda Anton-Culver and Argyrios Ziogas and Claus Hogdall and Estrid Hogdall and {Kr{\"u}ger Kjaer}, Susanne and Jan Blaakaer and Lydia Quaye and Ramus, {Susan J} and Ian Jacobs and Honglin Song and Pharoah, {Paul D P} and Iversen, {Edwin S} and Marks, {Jeffrey R} and Pike, {Malcolm C} and Gayther, {Simon A} and Cunningham, {Julie M} and H{\o}gdall, {Claus Kim}",
year = "2010",
month = feb,
day = "1",
doi = "http://dx.doi.org/10.1158/1055-9965.EPI-09-0861",
language = "English",
volume = "19",
pages = "600--4",
journal = "Cancer Epidemiology, Biomarkers & Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research (A A C R)",
number = "2",
}
RIS
TY - JOUR
T1 - Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium
AU - Phelan, Catherine M
AU - Tsai, Ya-Yu
AU - Goode, Ellen L
AU - Vierkant, Robert A
AU - Fridley, Brooke L
AU - Beesley, Jonathan
AU - Chen, Xiao Qing
AU - Webb, Penelope M
AU - Chanock, Stephen
AU - Cramer, Daniel W
AU - Moysich, Kirsten
AU - Edwards, Robert P
AU - Chang-Claude, Jenny
AU - Garcia-Closas, Montserrat
AU - Yang, Hannah
AU - Wang-Gohrke, Shan
AU - Hein, Rebecca
AU - Green, Adele C
AU - Lissowska, Jolanta
AU - Carney, Michael E
AU - Lurie, Galina
AU - Wilkens, Lynne R
AU - Ness, Roberta B
AU - Pearce, Celeste Leigh
AU - Wu, Anna H
AU - Van Den Berg, David J
AU - Stram, Daniel O
AU - Terry, Kathryn L
AU - Whiteman, David C
AU - Whittemore, Alice S
AU - DiCioccio, Richard A
AU - McGuire, Valerie
AU - Doherty, Jennifer A
AU - Rossing, Mary Anne
AU - Anton-Culver, Hoda
AU - Ziogas, Argyrios
AU - Hogdall, Claus
AU - Hogdall, Estrid
AU - Krüger Kjaer, Susanne
AU - Blaakaer, Jan
AU - Quaye, Lydia
AU - Ramus, Susan J
AU - Jacobs, Ian
AU - Song, Honglin
AU - Pharoah, Paul D P
AU - Iversen, Edwin S
AU - Marks, Jeffrey R
AU - Pike, Malcolm C
AU - Gayther, Simon A
AU - Cunningham, Julie M
AU - Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer)
PY - 2010/2/1
Y1 - 2010/2/1
N2 - Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for heterogeneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.
AB - Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for heterogeneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.
U2 - http://dx.doi.org/10.1158/1055-9965.EPI-09-0861
DO - http://dx.doi.org/10.1158/1055-9965.EPI-09-0861
M3 - Journal article
VL - 19
SP - 600
EP - 604
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
SN - 1055-9965
IS - 2
ER -
