Predictors of pretreatment CA125 at ovarian cancer diagnosis: a pooled analysis in the Ovarian Cancer Association Consortium
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Predictors of pretreatment CA125 at ovarian cancer diagnosis : a pooled analysis in the Ovarian Cancer Association Consortium. / Babic, Ana; Cramer, Daniel W; Kelemen, Linda E; Köbel, Martin; Steed, Helen; Webb, Penelope M; Johnatty, Sharon E; deFazio, Anna; Lambrechts, Diether; Goodman, Marc T; Heitz, Florian; Matsuo, Keitaro; Hosono, Satoyo; Karlan, Beth Y; Jensen, Allan; Kjær, Susanne K; Goode, Ellen L; Pejovic, Tanja; Moffitt, Melissa; Høgdall, Estrid; Høgdall, Claus; McNeish, Iain; Terry, Kathryn L.
I: Cancer Causes & Control, Bind 28, Nr. 5, 2017, s. 459-468.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Predictors of pretreatment CA125 at ovarian cancer diagnosis
T2 - a pooled analysis in the Ovarian Cancer Association Consortium
AU - Babic, Ana
AU - Cramer, Daniel W
AU - Kelemen, Linda E
AU - Köbel, Martin
AU - Steed, Helen
AU - Webb, Penelope M
AU - Johnatty, Sharon E
AU - deFazio, Anna
AU - Lambrechts, Diether
AU - Goodman, Marc T
AU - Heitz, Florian
AU - Matsuo, Keitaro
AU - Hosono, Satoyo
AU - Karlan, Beth Y
AU - Jensen, Allan
AU - Kjær, Susanne K
AU - Goode, Ellen L
AU - Pejovic, Tanja
AU - Moffitt, Melissa
AU - Høgdall, Estrid
AU - Høgdall, Claus
AU - McNeish, Iain
AU - Terry, Kathryn L
PY - 2017
Y1 - 2017
N2 - PURPOSE: Cancer antigen 125 (CA125) is a glycoprotein expressed by epithelial cells of several normal tissue types and overexpressed by several epithelial cancers. Serum CA125 levels are mostly used as an aid in the diagnosis of ovarian cancer patients, to monitor response to treatment and detect cancer recurrence. Besides tumor characteristics, CA125 levels are also influenced by several epidemiologic factors, such as age, parity, and oral contraceptive use. Identifying factors that influence CA125 levels in ovarian cancer patients could aid in the interpretation of CA125 values for individuals.METHODS: We evaluated predictors of pretreatment CA125 in 13 studies participating in the Ovarian Cancer Association Consortium. This analysis included a total of 5,091 women with invasive epithelial ovarian cancer with pretreatment CA125 measurements. We used probit scores to account for variability in CA125 between studies and linear regression to estimate the association between epidemiologic factors and tumor characteristics and pretreatment CA125 levels.RESULTS: In age-adjusted models, older age, history of pregnancy, history of tubal ligation, family history of breast cancer, and family history of ovarian cancer were associated with higher CA125 levels while endometriosis was associated with lower CA125 levels. After adjusting for tumor-related characteristics (stage, histology, grade), body mass index (BMI) higher than 30 kg/m2was associated with 10% (95% CI 2, 19%) higher CA125 levels, while race (non-white vs. white) was associated with 15% (95% CI 4, 27%) higher CA125 levels.CONCLUSION: Our results suggest that high BMI and race may influence CA125 levels independent of tumor characteristics. Validation is needed in studies that use a single assay for CA125 measurement and have a diverse study population.
AB - PURPOSE: Cancer antigen 125 (CA125) is a glycoprotein expressed by epithelial cells of several normal tissue types and overexpressed by several epithelial cancers. Serum CA125 levels are mostly used as an aid in the diagnosis of ovarian cancer patients, to monitor response to treatment and detect cancer recurrence. Besides tumor characteristics, CA125 levels are also influenced by several epidemiologic factors, such as age, parity, and oral contraceptive use. Identifying factors that influence CA125 levels in ovarian cancer patients could aid in the interpretation of CA125 values for individuals.METHODS: We evaluated predictors of pretreatment CA125 in 13 studies participating in the Ovarian Cancer Association Consortium. This analysis included a total of 5,091 women with invasive epithelial ovarian cancer with pretreatment CA125 measurements. We used probit scores to account for variability in CA125 between studies and linear regression to estimate the association between epidemiologic factors and tumor characteristics and pretreatment CA125 levels.RESULTS: In age-adjusted models, older age, history of pregnancy, history of tubal ligation, family history of breast cancer, and family history of ovarian cancer were associated with higher CA125 levels while endometriosis was associated with lower CA125 levels. After adjusting for tumor-related characteristics (stage, histology, grade), body mass index (BMI) higher than 30 kg/m2was associated with 10% (95% CI 2, 19%) higher CA125 levels, while race (non-white vs. white) was associated with 15% (95% CI 4, 27%) higher CA125 levels.CONCLUSION: Our results suggest that high BMI and race may influence CA125 levels independent of tumor characteristics. Validation is needed in studies that use a single assay for CA125 measurement and have a diverse study population.
KW - Adult
KW - Aged
KW - Biomarkers, Tumor/blood
KW - CA-125 Antigen/blood
KW - Female
KW - Humans
KW - Middle Aged
KW - Neoplasm Recurrence, Local/blood
KW - Ovarian Neoplasms/blood
KW - Parity
KW - Pregnancy
KW - Prognosis
U2 - 10.1007/s10552-016-0841-3
DO - 10.1007/s10552-016-0841-3
M3 - Journal article
C2 - 28050675
VL - 28
SP - 459
EP - 468
JO - Cancer Causes & Control
JF - Cancer Causes & Control
SN - 0957-5243
IS - 5
ER -
ID: 194974808