Prospects of Improving Early Ovarian Cancer Diagnosis Using Cervical Cell Swabs

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Prospects of Improving Early Ovarian Cancer Diagnosis Using Cervical Cell Swabs. / Biskup, Edyta; Wils, Regitze Solling; Hogdall, Claus; Hogdall, Estrid.

I: Anticancer Research, Bind 42, Nr. 1, 2022, s. 1-12.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Biskup, E, Wils, RS, Hogdall, C & Hogdall, E 2022, 'Prospects of Improving Early Ovarian Cancer Diagnosis Using Cervical Cell Swabs', Anticancer Research, bind 42, nr. 1, s. 1-12. https://doi.org/10.21873/anticanres.15451

APA

Biskup, E., Wils, R. S., Hogdall, C., & Hogdall, E. (2022). Prospects of Improving Early Ovarian Cancer Diagnosis Using Cervical Cell Swabs. Anticancer Research, 42(1), 1-12. https://doi.org/10.21873/anticanres.15451

Vancouver

Biskup E, Wils RS, Hogdall C, Hogdall E. Prospects of Improving Early Ovarian Cancer Diagnosis Using Cervical Cell Swabs. Anticancer Research. 2022;42(1):1-12. https://doi.org/10.21873/anticanres.15451

Author

Biskup, Edyta ; Wils, Regitze Solling ; Hogdall, Claus ; Hogdall, Estrid. / Prospects of Improving Early Ovarian Cancer Diagnosis Using Cervical Cell Swabs. I: Anticancer Research. 2022 ; Bind 42, Nr. 1. s. 1-12.

Bibtex

@article{c753ffea548d4d8f80645d5de84ad9d3,
title = "Prospects of Improving Early Ovarian Cancer Diagnosis Using Cervical Cell Swabs",
abstract = "Ovarian cancer (OC) has the poorest prognosis and the highest mortality rate among gynecological malignancies, which is largely due to delayed diagnosis. Therefore, an effective detection strategy is a compelling need. Here, we review the potential use of cervical cell swabs (Pap specimens, liquid) for early detection of OC. It has been shown, that malignant cells exfoliate from the ovaries and may be detected in Pap specimens, routinely collected through cervical cancer screening. Using Medical Subject Headings (MeSH) for searching the PubMed database we identified eight studies reporting the use of Pap specimen in early detection of OC. Six focused on detection of gene mutations, using gene panels or analysis of TP53 variants. Two studies reported analysis of methylation profiles. Seven studies were published in 2018 or later. Additionally, we found one study without MeSH terms assigned yet, which postulated using peptide biomarkers present in Pap-test fluid. In this review we present their main findings, discuss challenges this approach presents and include ideas for improved detection.",
keywords = "Cervical swab, Liquid Pap specimen, Ovarian cancer, Pap test, Review",
author = "Edyta Biskup and Wils, {Regitze Solling} and Claus Hogdall and Estrid Hogdall",
note = "Publisher Copyright: {\textcopyright} 2022 International Institute of Anticancer Research. All rights reserved.",
year = "2022",
doi = "10.21873/anticanres.15451",
language = "English",
volume = "42",
pages = "1--12",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "1",

}

RIS

TY - JOUR

T1 - Prospects of Improving Early Ovarian Cancer Diagnosis Using Cervical Cell Swabs

AU - Biskup, Edyta

AU - Wils, Regitze Solling

AU - Hogdall, Claus

AU - Hogdall, Estrid

N1 - Publisher Copyright: © 2022 International Institute of Anticancer Research. All rights reserved.

PY - 2022

Y1 - 2022

N2 - Ovarian cancer (OC) has the poorest prognosis and the highest mortality rate among gynecological malignancies, which is largely due to delayed diagnosis. Therefore, an effective detection strategy is a compelling need. Here, we review the potential use of cervical cell swabs (Pap specimens, liquid) for early detection of OC. It has been shown, that malignant cells exfoliate from the ovaries and may be detected in Pap specimens, routinely collected through cervical cancer screening. Using Medical Subject Headings (MeSH) for searching the PubMed database we identified eight studies reporting the use of Pap specimen in early detection of OC. Six focused on detection of gene mutations, using gene panels or analysis of TP53 variants. Two studies reported analysis of methylation profiles. Seven studies were published in 2018 or later. Additionally, we found one study without MeSH terms assigned yet, which postulated using peptide biomarkers present in Pap-test fluid. In this review we present their main findings, discuss challenges this approach presents and include ideas for improved detection.

AB - Ovarian cancer (OC) has the poorest prognosis and the highest mortality rate among gynecological malignancies, which is largely due to delayed diagnosis. Therefore, an effective detection strategy is a compelling need. Here, we review the potential use of cervical cell swabs (Pap specimens, liquid) for early detection of OC. It has been shown, that malignant cells exfoliate from the ovaries and may be detected in Pap specimens, routinely collected through cervical cancer screening. Using Medical Subject Headings (MeSH) for searching the PubMed database we identified eight studies reporting the use of Pap specimen in early detection of OC. Six focused on detection of gene mutations, using gene panels or analysis of TP53 variants. Two studies reported analysis of methylation profiles. Seven studies were published in 2018 or later. Additionally, we found one study without MeSH terms assigned yet, which postulated using peptide biomarkers present in Pap-test fluid. In this review we present their main findings, discuss challenges this approach presents and include ideas for improved detection.

KW - Cervical swab

KW - Liquid Pap specimen

KW - Ovarian cancer

KW - Pap test

KW - Review

U2 - 10.21873/anticanres.15451

DO - 10.21873/anticanres.15451

M3 - Review

C2 - 34969703

AN - SCOPUS:85121987550

VL - 42

SP - 1

EP - 12

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 1

ER -

ID: 317955413