An overview of obesity mechanisms in humans: Endocrine regulation of food intake, eating behaviour and common determinants of body weight
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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An overview of obesity mechanisms in humans : Endocrine regulation of food intake, eating behaviour and common determinants of body weight. / Theilade, Simone; Christensen, Mikkel B.; Vilsbøll, Tina; Knop, Filip K.
I: Diabetes, Obesity and Metabolism, Bind 23, Nr. S1, 2021, s. 17-35.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - An overview of obesity mechanisms in humans
T2 - Endocrine regulation of food intake, eating behaviour and common determinants of body weight
AU - Theilade, Simone
AU - Christensen, Mikkel B.
AU - Vilsbøll, Tina
AU - Knop, Filip K.
N1 - Supplement: OBESITY AS A LIFE‐THREATENING DISEASE: The Importance of Individualized Patient Assessments & Evidence‐based Interventions to Improve Outcomes
PY - 2021
Y1 - 2021
N2 - Obesity is one of the biggest health challenges of the 21st century, already affecting close to 700 million people worldwide, debilitating and shortening lives and costing billions of pounds in healthcare costs and loss of workability. Body weight homeostasis relies on complex biological mechanisms and the development of obesity occurs on a background of genetic susceptibility and an environment promoting increased caloric intake and reduced physical activity. The pathophysiology of common obesity links neuro-endocrine and metabolic disturbances with behavioural changes, genetics, epigenetics and cultural habits. Also, specific causes of obesity exist, including monogenetic diseases and iatrogenic causes. In this review, we provide an overview of obesity mechanisms in humans with a focus on energy homeostasis, endocrine regulation of food intake and eating behavior, as well as the most common specific causes of obesity.
AB - Obesity is one of the biggest health challenges of the 21st century, already affecting close to 700 million people worldwide, debilitating and shortening lives and costing billions of pounds in healthcare costs and loss of workability. Body weight homeostasis relies on complex biological mechanisms and the development of obesity occurs on a background of genetic susceptibility and an environment promoting increased caloric intake and reduced physical activity. The pathophysiology of common obesity links neuro-endocrine and metabolic disturbances with behavioural changes, genetics, epigenetics and cultural habits. Also, specific causes of obesity exist, including monogenetic diseases and iatrogenic causes. In this review, we provide an overview of obesity mechanisms in humans with a focus on energy homeostasis, endocrine regulation of food intake and eating behavior, as well as the most common specific causes of obesity.
KW - appetite control
KW - energy regulation
KW - obesity therapy
U2 - 10.1111/dom.14270
DO - 10.1111/dom.14270
M3 - Review
C2 - 33621414
VL - 23
SP - 17
EP - 35
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
SN - 1462-8902
IS - S1
ER -
ID: 257653591