Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes

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Standard

Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes. / Christensen, Regitse H.; Hansen, Christian S.; von Scholten, Bernt Johan; Jensen, Magnus T.; Pedersen, Bente K.; Schnohr, Peter; Vilsbøll, Tina; Rossing, Peter; Jørgensen, Peter G.

I: Diabetes, Obesity and Metabolism, Bind 21, Nr. 8, 2019, s. 2006-2011.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Christensen, RH, Hansen, CS, von Scholten, BJ, Jensen, MT, Pedersen, BK, Schnohr, P, Vilsbøll, T, Rossing, P & Jørgensen, PG 2019, 'Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes', Diabetes, Obesity and Metabolism, bind 21, nr. 8, s. 2006-2011. https://doi.org/10.1111/dom.13758

APA

Christensen, R. H., Hansen, C. S., von Scholten, B. J., Jensen, M. T., Pedersen, B. K., Schnohr, P., Vilsbøll, T., Rossing, P., & Jørgensen, P. G. (2019). Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes. Diabetes, Obesity and Metabolism, 21(8), 2006-2011. https://doi.org/10.1111/dom.13758

Vancouver

Christensen RH, Hansen CS, von Scholten BJ, Jensen MT, Pedersen BK, Schnohr P o.a. Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes. Diabetes, Obesity and Metabolism. 2019;21(8):2006-2011. https://doi.org/10.1111/dom.13758

Author

Christensen, Regitse H. ; Hansen, Christian S. ; von Scholten, Bernt Johan ; Jensen, Magnus T. ; Pedersen, Bente K. ; Schnohr, Peter ; Vilsbøll, Tina ; Rossing, Peter ; Jørgensen, Peter G. / Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes. I: Diabetes, Obesity and Metabolism. 2019 ; Bind 21, Nr. 8. s. 2006-2011.

Bibtex

@article{1b00ad48490f4b8eb50a0ef4c8d296c7,
title = "Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes",
abstract = "The aim of this study was to investigate the association of epicardial (EAT) and pericardial (PAT) adipose tissues with myocardial function in type 2 diabetes (T2D). EAT and PAT were measured by ultrasound in 770 patients with T2D and 234 age- and sex-matched non-diabetic controls. Echocardiography was performed, including tissue Doppler imaging and 2D speckle tracking. Patients with T2D versus controls had increased EAT (4.6 ± 1.8 mm vs. 3.4 ± 1.2 mm, P < 0.0001) and PAT (6.3 ± 2.8 mm vs. 5.3 ± 2.4 mm, P < 0.0001). EAT and PAT were associated with structural cardiac measures both in T2D patients and controls (all P < 0.043), but only in T2D patients with functional measures: PAT was associated with impaired global longitudinal strain [beta coefficient (SE)] [0.11% (0.04), P = 0.002], while EAT was associated with reduced diastolic function by lateral early diastolic myocardial velocity (e{\textquoteright}lat) [−0.31 (0.05) cm/s, P = 0.001], mitral inflow velocities: peak early (E)/peak atrial (A) ratio [−0.02 (0.01), P = 0.001] and lateral E/e{\textquoteright}lat [0.36 (0.10), P < 0.001]. However, no interaction was found between diabetes status and PAT (P = 0.75) or EAT (P = 0.45). Adipose tissue in intimate relation to the myocardium is higher in patients with T2D versus controls and is associated with functional myocardial measures in T2D.",
keywords = "cardiac adipose tissue, diastolic dysfunction, epicardial adipose tissue, pericardial adipose tissue, systolic dysfunction, type 2 diabetes",
author = "Christensen, {Regitse H.} and Hansen, {Christian S.} and {von Scholten}, {Bernt Johan} and Jensen, {Magnus T.} and Pedersen, {Bente K.} and Peter Schnohr and Tina Vilsb{\o}ll and Peter Rossing and J{\o}rgensen, {Peter G.}",
year = "2019",
doi = "10.1111/dom.13758",
language = "English",
volume = "21",
pages = "2006--2011",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell",
number = "8",

}

RIS

TY - JOUR

T1 - Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes

AU - Christensen, Regitse H.

AU - Hansen, Christian S.

AU - von Scholten, Bernt Johan

AU - Jensen, Magnus T.

AU - Pedersen, Bente K.

AU - Schnohr, Peter

AU - Vilsbøll, Tina

AU - Rossing, Peter

AU - Jørgensen, Peter G.

PY - 2019

Y1 - 2019

N2 - The aim of this study was to investigate the association of epicardial (EAT) and pericardial (PAT) adipose tissues with myocardial function in type 2 diabetes (T2D). EAT and PAT were measured by ultrasound in 770 patients with T2D and 234 age- and sex-matched non-diabetic controls. Echocardiography was performed, including tissue Doppler imaging and 2D speckle tracking. Patients with T2D versus controls had increased EAT (4.6 ± 1.8 mm vs. 3.4 ± 1.2 mm, P < 0.0001) and PAT (6.3 ± 2.8 mm vs. 5.3 ± 2.4 mm, P < 0.0001). EAT and PAT were associated with structural cardiac measures both in T2D patients and controls (all P < 0.043), but only in T2D patients with functional measures: PAT was associated with impaired global longitudinal strain [beta coefficient (SE)] [0.11% (0.04), P = 0.002], while EAT was associated with reduced diastolic function by lateral early diastolic myocardial velocity (e’lat) [−0.31 (0.05) cm/s, P = 0.001], mitral inflow velocities: peak early (E)/peak atrial (A) ratio [−0.02 (0.01), P = 0.001] and lateral E/e’lat [0.36 (0.10), P < 0.001]. However, no interaction was found between diabetes status and PAT (P = 0.75) or EAT (P = 0.45). Adipose tissue in intimate relation to the myocardium is higher in patients with T2D versus controls and is associated with functional myocardial measures in T2D.

AB - The aim of this study was to investigate the association of epicardial (EAT) and pericardial (PAT) adipose tissues with myocardial function in type 2 diabetes (T2D). EAT and PAT were measured by ultrasound in 770 patients with T2D and 234 age- and sex-matched non-diabetic controls. Echocardiography was performed, including tissue Doppler imaging and 2D speckle tracking. Patients with T2D versus controls had increased EAT (4.6 ± 1.8 mm vs. 3.4 ± 1.2 mm, P < 0.0001) and PAT (6.3 ± 2.8 mm vs. 5.3 ± 2.4 mm, P < 0.0001). EAT and PAT were associated with structural cardiac measures both in T2D patients and controls (all P < 0.043), but only in T2D patients with functional measures: PAT was associated with impaired global longitudinal strain [beta coefficient (SE)] [0.11% (0.04), P = 0.002], while EAT was associated with reduced diastolic function by lateral early diastolic myocardial velocity (e’lat) [−0.31 (0.05) cm/s, P = 0.001], mitral inflow velocities: peak early (E)/peak atrial (A) ratio [−0.02 (0.01), P = 0.001] and lateral E/e’lat [0.36 (0.10), P < 0.001]. However, no interaction was found between diabetes status and PAT (P = 0.75) or EAT (P = 0.45). Adipose tissue in intimate relation to the myocardium is higher in patients with T2D versus controls and is associated with functional myocardial measures in T2D.

KW - cardiac adipose tissue

KW - diastolic dysfunction

KW - epicardial adipose tissue

KW - pericardial adipose tissue

KW - systolic dysfunction

KW - type 2 diabetes

U2 - 10.1111/dom.13758

DO - 10.1111/dom.13758

M3 - Journal article

C2 - 31050126

AN - SCOPUS:85066148305

VL - 21

SP - 2006

EP - 2011

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 8

ER -

ID: 228819041