Exenatide: pharmacokinetics, clinical use, and future directions
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Exenatide : pharmacokinetics, clinical use, and future directions. / Knop, Filip K.; Bronden, Andreas; Lauritsen, Tina Vilsbøll.
I: Expert Opinion on Pharmacotherapy, Bind 18, Nr. 6, 2017, s. 555-571.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Exenatide
T2 - pharmacokinetics, clinical use, and future directions
AU - Knop, Filip K.
AU - Bronden, Andreas
AU - Lauritsen, Tina Vilsbøll
N1 - M1 - Copyright (C) 2017 U.S. National Library of Medicine. MEDLINE AN 2018155510(Journal; Article; (JOURNAL ARTICLE))
PY - 2017
Y1 - 2017
N2 - INTRODUCTION: The first-in-class glucagon-like peptide-1 receptor agonist (GLP-1RA) exenatide, which was initially approved in 2005, is available in twice-daily (BID) and once-weekly (QW) formulations. Clinical trial data suggest both formulations are effective and safe for patients with type 2 diabetes (T2D), both as monotherapy and as part of combination therapy. Since exenatide was approved, several other GLP-1RAs have become available for clinical use. Areas covered: Many ongoing clinical trials involving exenatide BID and exenatide QW are investigating new indications (exenatide BID) and new end points and combination therapies (exenatide QW). This review provides an overview of the delivery and pharmacokinetics of both formulations of exenatide, reviews existing data in T2D, and summarizes ongoing investigations. Expert opinion: Exenatide BID and QW have substantial clinical benefits. Comparisons with other GLP-1RAs demonstrate some differences in efficacy and safety profiles that make assessment of benefit:risk ratios complex. Head-to-head comparisons of QW GLP-1RA formulations may assist in the ranking of GLP-1RAs according to efficacy and safety. Results on the impact of exenatide QW on cardiovascular outcomes are eagerly awaited. The potential clinical utility of exenatide BID in other indications will clarify whether exenatide holds clinical promise in diagnoses other than T2D.[on SciFinder (R)]
AB - INTRODUCTION: The first-in-class glucagon-like peptide-1 receptor agonist (GLP-1RA) exenatide, which was initially approved in 2005, is available in twice-daily (BID) and once-weekly (QW) formulations. Clinical trial data suggest both formulations are effective and safe for patients with type 2 diabetes (T2D), both as monotherapy and as part of combination therapy. Since exenatide was approved, several other GLP-1RAs have become available for clinical use. Areas covered: Many ongoing clinical trials involving exenatide BID and exenatide QW are investigating new indications (exenatide BID) and new end points and combination therapies (exenatide QW). This review provides an overview of the delivery and pharmacokinetics of both formulations of exenatide, reviews existing data in T2D, and summarizes ongoing investigations. Expert opinion: Exenatide BID and QW have substantial clinical benefits. Comparisons with other GLP-1RAs demonstrate some differences in efficacy and safety profiles that make assessment of benefit:risk ratios complex. Head-to-head comparisons of QW GLP-1RA formulations may assist in the ranking of GLP-1RAs according to efficacy and safety. Results on the impact of exenatide QW on cardiovascular outcomes are eagerly awaited. The potential clinical utility of exenatide BID in other indications will clarify whether exenatide holds clinical promise in diagnoses other than T2D.[on SciFinder (R)]
KW - exenatide
KW - extended-release
KW - glucagon-like peptide-1 receptor agonist
KW - glycemic control
KW - type 2 diabetes
U2 - 10.1080/14656566.2017.1282463
DO - 10.1080/14656566.2017.1282463
M3 - Review
C2 - 28085521
VL - 18
SP - 555
EP - 571
JO - Expert Opinion on Pharmacotherapy
JF - Expert Opinion on Pharmacotherapy
SN - 1465-6566
IS - 6
ER -
ID: 174465079