Glucagon-like peptide 1-baseret behandling af type 2-diabetes mellitus
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Glucagon-like peptide 1-baseret behandling af type 2-diabetes mellitus. / Knop, Filip Krag; Vilsbøll, Tina.
I: Ugeskrift for Laeger, Bind 169, Nr. 22, 28.05.2007, s. 2095-9.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Glucagon-like peptide 1-baseret behandling af type 2-diabetes mellitus
AU - Knop, Filip Krag
AU - Vilsbøll, Tina
PY - 2007/5/28
Y1 - 2007/5/28
N2 - GLP-1 is secreted from the small intestine in response to ingestion of nutrients. It has a powerful insulinotropic effect and stimulates beta-cell growth and is therefore being developed for treatment of type 2 diabetes. The GLP-1 analogue, exenatide, is on the market in the USA as an add-on therapy. Another strategy to increase circulating GLP-1 is to inhibit the enzyme DPP-IV which degrades endogenous GLP-1. GLP-1-based therapy results in HbA1c reductions of approximately 1 percent point, and the lack of serious side effects and the low risk of hypoglycaemic episodes are unique traits.
AB - GLP-1 is secreted from the small intestine in response to ingestion of nutrients. It has a powerful insulinotropic effect and stimulates beta-cell growth and is therefore being developed for treatment of type 2 diabetes. The GLP-1 analogue, exenatide, is on the market in the USA as an add-on therapy. Another strategy to increase circulating GLP-1 is to inhibit the enzyme DPP-IV which degrades endogenous GLP-1. GLP-1-based therapy results in HbA1c reductions of approximately 1 percent point, and the lack of serious side effects and the low risk of hypoglycaemic episodes are unique traits.
M3 - Review
VL - 169
SP - 2095
EP - 2099
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 22
ER -
ID: 34145124