Glucose-Dependent Insulinotropic Polypeptide (GIP) Reduces Bone Resorption in Patients With Type 2 Diabetes
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- Glucose-Dependent Insulinotropic Polypeptide (GIP) Reduces Bone Resorption in Patients With Type 2 Diabetes
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Context: In healthy individuals, glucose-dependent insulinotropic polypeptide (GIP) enhances insulin secretion and reduces bone resorption by up to 25% estimated by absolute placebo-corrected changes in carboxy-terminal type 1 collagen crosslinks (CTX) during GIP and glucose administration. In patients with type 2 diabetes (T2D), GIP's insulinotropic effect is impaired and effects on bone may be reduced.
Objective: To investigate GIP's effect on bone biomarkers in patients with T2D.
Design: Randomized, double-blinded, crossover study investigating 6 interventions.
Patients: Twelve male patients with T2D.
Interventions: A primed continuous 90-minute GIP infusion (2 pmollkg/min) or matching placebo (saline) administered at 3 plasma glucose (PG) levels (i.e., paired days with "insulin-induced hypoglycemia" (PG lowered to 3 mmol/L), "fasting hyperglycemia" (mean PG similar to 8 mmol/L), or "aggravated hyperglycemia" (mean PG similar to 12 mmol/L).
Main Outcome Measures: Bone biomarkers: CTX, procollagen type 1 N-terminal propeptide (P1NP) and PTH.
Results: On days with insulin-induced hypoglycemia, CTX was suppressed by up to 40 +/- 15% during GIP administration compared with 12 +/- 11% during placebo infusion (P<0.0001). On days with fasting hyperglycemia, CTX was suppressed by up to 36 +/- 15% during GIP administration, compared with 0 +/- 9% during placebo infusion (P<0.0001). On days with aggravated hyperglycemia, CTX was suppressed by up to 47 +/- 23% during GIP administration compared with 10 +/- 9% during placebo infusion (P= 0.0005). At all glycemic levels, P1NP and PHI concentrations were similar between paired days after 90 minutes.
Conclusions: Short-term GIP infusions reduce bone resorption by more than one-third (estimated by absolute placebo-corrected CTX reductions) in patients with T2DM, suggesting preserved bone effects of GIP in these patients.
Precis: Short-term GIP infusions reduce the bone resorption marker CTX by one-third in patients with type 2 diabetes independent of glycemic levels. (C) Endocrine Society 2020.
Originalsprog | Engelsk |
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Artikelnummer | 097 |
Tidsskrift | Journal of the endocrine society |
Vol/bind | 4 |
Udgave nummer | 9 |
Antal sider | 9 |
DOI | |
Status | Udgivet - 2020 |
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