Glycaemia and cardiac arrhythmias in people with type 1 diabetes: A prospective observational study
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Glycaemia and cardiac arrhythmias in people with type 1 diabetes : A prospective observational study. / Hagelqvist, Per G.; Andersen, Andreas; Maytham, Kaisar; Andreasen, Christine R.; Engberg, Susanne; Lindhardt, Tommi B.; Forman, Julie L.; Pedersen-Bjergaard, Ulrik; Knop, Filip K.; Vilsbøll, Tina.
I: Diabetes, Obesity and Metabolism, Bind 25, Nr. 8, 2023, s. 2300-2309.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Glycaemia and cardiac arrhythmias in people with type 1 diabetes
T2 - A prospective observational study
AU - Hagelqvist, Per G.
AU - Andersen, Andreas
AU - Maytham, Kaisar
AU - Andreasen, Christine R.
AU - Engberg, Susanne
AU - Lindhardt, Tommi B.
AU - Forman, Julie L.
AU - Pedersen-Bjergaard, Ulrik
AU - Knop, Filip K.
AU - Vilsbøll, Tina
N1 - Publisher Copyright: © 2023 John Wiley & Sons Ltd.
PY - 2023
Y1 - 2023
N2 - Aim: To investigate the impact of hypoglycaemia, hyperglycaemia and glycaemic variability on arrhythmia susceptibility in people with type 1 diabetes. Materials and Methods: Thirty adults with type 1 diabetes were included in a 12-month observational exploratory study. Daytime and night-time incident rate ratios (IRRs) of arrhythmias were determined for hypoglycaemia (interstitial glucose [IG] <3.9 mmol/L), hyperglycaemia (IG >10.0 mmol/L) and glycaemic variability (standard deviation and coefficient of variation). Results: Hypoglycaemia was not associated with an increased risk of arrhythmias compared with euglycaemia and hyperglycaemia combined (IG ≥ 3.9 mmol/L). However, during daytime, a trend of increased risk of arrhythmias was observed when comparing time spent in hypoglycaemia with euglycaemia (IRR 1.08 [95% CI: 0.99-1.18] per 5 minutes). Furthermore, during daytime, both the occurrence and time spent in hyperglycaemia were associated with an increased risk of arrhythmias compared with euglycaemia (IRR 2.03 [95% CI: 1.21-3.40] and IRR 1.07 [95% CI: 1.02-1.13] per 5 minutes, respectively). Night-time hypoglycaemia and hyperglycaemia were not associated with the risk of arrhythmias. Increased glycaemic variability was not associated with an increased risk of arrhythmias during daytime, whereas a reduced risk was observed during night-time. Conclusions: Acute hypoglycaemia and hyperglycaemia during daytime may increase the risk of arrhythmias in individuals with type 1 diabetes. However, no such associations were found during night-time, indicating diurnal differences in arrhythmia susceptibility.
AB - Aim: To investigate the impact of hypoglycaemia, hyperglycaemia and glycaemic variability on arrhythmia susceptibility in people with type 1 diabetes. Materials and Methods: Thirty adults with type 1 diabetes were included in a 12-month observational exploratory study. Daytime and night-time incident rate ratios (IRRs) of arrhythmias were determined for hypoglycaemia (interstitial glucose [IG] <3.9 mmol/L), hyperglycaemia (IG >10.0 mmol/L) and glycaemic variability (standard deviation and coefficient of variation). Results: Hypoglycaemia was not associated with an increased risk of arrhythmias compared with euglycaemia and hyperglycaemia combined (IG ≥ 3.9 mmol/L). However, during daytime, a trend of increased risk of arrhythmias was observed when comparing time spent in hypoglycaemia with euglycaemia (IRR 1.08 [95% CI: 0.99-1.18] per 5 minutes). Furthermore, during daytime, both the occurrence and time spent in hyperglycaemia were associated with an increased risk of arrhythmias compared with euglycaemia (IRR 2.03 [95% CI: 1.21-3.40] and IRR 1.07 [95% CI: 1.02-1.13] per 5 minutes, respectively). Night-time hypoglycaemia and hyperglycaemia were not associated with the risk of arrhythmias. Increased glycaemic variability was not associated with an increased risk of arrhythmias during daytime, whereas a reduced risk was observed during night-time. Conclusions: Acute hypoglycaemia and hyperglycaemia during daytime may increase the risk of arrhythmias in individuals with type 1 diabetes. However, no such associations were found during night-time, indicating diurnal differences in arrhythmia susceptibility.
KW - cardiovascular disease
KW - continuous glucose monitoring
KW - hyperglycaemia
KW - hypoglycaemia
KW - observational study
KW - type 1 diabetes
U2 - 10.1111/dom.15108
DO - 10.1111/dom.15108
M3 - Journal article
C2 - 37203283
AN - SCOPUS:85159647524
VL - 25
SP - 2300
EP - 2309
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
SN - 1462-8902
IS - 8
ER -
ID: 348166418