Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophysiological trait or a consequence of developing diabetes. Therefore, we aimed to investigate the insulinotropic effect of GIP and GLP-1 compared with placebo before and after 12 d of glucose homeostatic dysregulation in healthy subjects.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Clinical Endocrinology and Metabolism |
Vol/bind | 97 |
Udgave nummer | 4 |
Sider (fra-til) | 1363-70 |
Antal sider | 8 |
ISSN | 0021-972X |
DOI | |
Status | Udgivet - 2012 |
ID: 40379513