Involvement of glucagon-like peptide-1 in the glucose-lowering effect of metformin
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Involvement of glucagon-like peptide-1 in the glucose-lowering effect of metformin. / Bahne, Emilie; Hansen, Morten; Brønden, Andreas; Sonne, David P; Lauritsen, Tina Vilsbøll; Knop, Filip K.
I: Diabetes, Obesity and Metabolism Online, Bind 18, Nr. 10, 10.2016, s. 955-61.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Involvement of glucagon-like peptide-1 in the glucose-lowering effect of metformin
AU - Bahne, Emilie
AU - Hansen, Morten
AU - Brønden, Andreas
AU - Sonne, David P
AU - Lauritsen, Tina Vilsbøll
AU - Knop, Filip K
N1 - © 2016 John Wiley & Sons Ltd.
PY - 2016/10
Y1 - 2016/10
N2 - Metformin is an oral antihyperglycaemic drug used in the first-line treatment of type 2 diabetes. Metformin's classic and most well-known blood glucose-lowering mechanisms include reduction of hepatic gluconeogenesis and increased peripheral insulin sensitivity. Interestingly, intravenously administered metformin is ineffective and recently, metformin was shown to increase plasma concentrations of the glucose-lowering gut incretin hormone glucagon-like peptide-1 (GLP-1), which may contribute to metformin's glucose-lowering effect in patients with type 2 diabetes. The mechanisms behind metformin-induced increments in GLP-1 levels remain unknown, but it has been hypothesized that metformin stimulates GLP-1 secretion directly and/or indirectly and that metformin prolongs the half-life of GLP-1. Also, it has been suggested that metformin may potentiate the glucose-lowering effects of GLP-1 by increasing target tissue sensitivity to GLP-1. The present article critically reviews the possible mechanisms by which metformin may affect GLP-1 levels and sensitivity and discusses whether such alterations may constitute important and clinically relevant glucose-lowering actions of metformin.
AB - Metformin is an oral antihyperglycaemic drug used in the first-line treatment of type 2 diabetes. Metformin's classic and most well-known blood glucose-lowering mechanisms include reduction of hepatic gluconeogenesis and increased peripheral insulin sensitivity. Interestingly, intravenously administered metformin is ineffective and recently, metformin was shown to increase plasma concentrations of the glucose-lowering gut incretin hormone glucagon-like peptide-1 (GLP-1), which may contribute to metformin's glucose-lowering effect in patients with type 2 diabetes. The mechanisms behind metformin-induced increments in GLP-1 levels remain unknown, but it has been hypothesized that metformin stimulates GLP-1 secretion directly and/or indirectly and that metformin prolongs the half-life of GLP-1. Also, it has been suggested that metformin may potentiate the glucose-lowering effects of GLP-1 by increasing target tissue sensitivity to GLP-1. The present article critically reviews the possible mechanisms by which metformin may affect GLP-1 levels and sensitivity and discusses whether such alterations may constitute important and clinically relevant glucose-lowering actions of metformin.
KW - Journal Article
KW - Review
U2 - 10.1111/dom.12697
DO - 10.1111/dom.12697
M3 - Review
C2 - 27265206
VL - 18
SP - 955
EP - 961
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
SN - 1462-8902
IS - 10
ER -
ID: 165938500