Liraglutide: a once-daily GLP-1 analogue for the treatment of type 2 diabetes mellitus
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Liraglutide: a once-daily GLP-1 analogue for the treatment of type 2 diabetes mellitus. / Vilsbøll, Tina.
I: Expert Opinion on Investigational Drugs, Bind 16, Nr. 2, 01.02.2007, s. 231-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Liraglutide: a once-daily GLP-1 analogue for the treatment of type 2 diabetes mellitus
AU - Vilsbøll, Tina
PY - 2007/2/1
Y1 - 2007/2/1
N2 - The incretin hormones are intestinal peptides that enhance insulin secretion following ingestion of nutrients. Liraglutide is a glucagon-like peptide-1 receptor analogue, which is obtained by derivatising glucagon-like peptide-1 with a fatty acid, providing a compound with pharmacokinetic properties that are suitable for once-daily dosing. Liraglutide has demonstrated lasting improvement of HbA(1c )levels, weight reduction and improved beta-cell function in patients with Type 2 diabetes mellitus. Liraglutide is well tolerated; the adverse events that are most frequently reported being transient nausea and diarrhoea. This article reviews the mechanisms of action and efficacy of liraglutide for the treatment of Type 2 diabetes mellitus. This agent is presently in Phase III clinical development.
AB - The incretin hormones are intestinal peptides that enhance insulin secretion following ingestion of nutrients. Liraglutide is a glucagon-like peptide-1 receptor analogue, which is obtained by derivatising glucagon-like peptide-1 with a fatty acid, providing a compound with pharmacokinetic properties that are suitable for once-daily dosing. Liraglutide has demonstrated lasting improvement of HbA(1c )levels, weight reduction and improved beta-cell function in patients with Type 2 diabetes mellitus. Liraglutide is well tolerated; the adverse events that are most frequently reported being transient nausea and diarrhoea. This article reviews the mechanisms of action and efficacy of liraglutide for the treatment of Type 2 diabetes mellitus. This agent is presently in Phase III clinical development.
U2 - http://dx.doi.org/10.1517/13543784.16.2.231
DO - http://dx.doi.org/10.1517/13543784.16.2.231
M3 - Journal article
VL - 16
SP - 231
EP - 237
JO - Current Opinion in Investigational Drugs
JF - Current Opinion in Investigational Drugs
SN - 1354-3784
IS - 2
ER -
ID: 40221748