Metformin er en mulig glukagonlignende peptid-1-stimulator
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Metformin er en mulig glukagonlignende peptid-1-stimulator. / Bahne, Emilie; Brønden, Andreas; Vilsbøll, Tina; Knop, Filip Krag.
I: Ugeskrift for Laeger, Bind 180, Nr. 12, V07170516, 2018.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Metformin er en mulig glukagonlignende peptid-1-stimulator
AU - Bahne, Emilie
AU - Brønden, Andreas
AU - Vilsbøll, Tina
AU - Knop, Filip Krag
PY - 2018
Y1 - 2018
N2 - Metformin is an oral anti-hyperglycaemic drug used as first-line treatment of Type 2 diabetes. It is more effective when administered orally than when administered intravenously, and metformin formulations, which prolong the time residing in the gut are the most potent. This indicates that the intestine plays an essential role in metformin's mode of action. Metformin also increases plasma concentrations of the glucose-lowering gut incretin hormone glucagon-like peptide-1 (GLP-1). This metformin-induced GLP-1 increment may constitute an important link between the gut and the glucose-lowering effect of metformin.
AB - Metformin is an oral anti-hyperglycaemic drug used as first-line treatment of Type 2 diabetes. It is more effective when administered orally than when administered intravenously, and metformin formulations, which prolong the time residing in the gut are the most potent. This indicates that the intestine plays an essential role in metformin's mode of action. Metformin also increases plasma concentrations of the glucose-lowering gut incretin hormone glucagon-like peptide-1 (GLP-1). This metformin-induced GLP-1 increment may constitute an important link between the gut and the glucose-lowering effect of metformin.
KW - Bile Acids and Salts/metabolism
KW - Dipeptidyl-Peptidase IV Inhibitors/metabolism
KW - Gastrointestinal Microbiome/drug effects
KW - Glucagon-Like Peptide 1/metabolism
KW - Humans
KW - Metformin/metabolism
M3 - Tidsskriftartikel
C2 - 29559078
VL - 180
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 12
M1 - V07170516
ER -
ID: 218615526