Survival of patients with and without diabetes following out-of-hospital cardiac arrest: A nationwide Danish study
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Survival of patients with and without diabetes following out-of-hospital cardiac arrest : A nationwide Danish study. / Mohr, Grímur Høgnason; Søndergaard, Kathrine B; Pallisgaard, Jannik L; Møller, Sidsel Gamborg; Wissenberg, Mads; Karlsson, Lena; Hansen, Steen Møller; Kragholm, Kristian; Køber, Lars; Lippert, Freddy; Folke, Fredrik; Vilsbøll, Tina; Torp-Pedersen, Christian; Gislason, Gunnar; Rajan, Shahzleen.
I: European Heart Journal: Acute Cardiovascular Care, Bind 9, Nr. 6, 2020, s. 599-607.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Survival of patients with and without diabetes following out-of-hospital cardiac arrest
T2 - A nationwide Danish study
AU - Mohr, Grímur Høgnason
AU - Søndergaard, Kathrine B
AU - Pallisgaard, Jannik L
AU - Møller, Sidsel Gamborg
AU - Wissenberg, Mads
AU - Karlsson, Lena
AU - Hansen, Steen Møller
AU - Kragholm, Kristian
AU - Køber, Lars
AU - Lippert, Freddy
AU - Folke, Fredrik
AU - Vilsbøll, Tina
AU - Torp-Pedersen, Christian
AU - Gislason, Gunnar
AU - Rajan, Shahzleen
PY - 2020
Y1 - 2020
N2 - BACKGROUND:: Research regarding out-of-hospital cardiac arrest (OHCA) survival of diabetes patients is sparse and it remains unknown whether initiatives to increase OHCA survival benefit diabetes and non-diabetes patients equally. We therefore examined overall and temporal survival in diabetes and non-diabetes patients following OHCA.METHODS:: Adult presumed cardiac-caused OHCAs were identified from the Danish Cardiac Arrest Registry (2001-2014). Associations between diabetes and return of spontaneous circulation upon hospital arrival and 30-day survival were estimated with logistic regression adjusted for patient- and OHCA-related characteristics.RESULTS:: In total, 28,955 OHCAs were included of which 4276 (14.8%) had diabetes. Compared with non-diabetes patients, diabetes patients had more comorbidities, same prevalence of bystander-witnessed arrests (51.7% vs. 52.7%) and bystander cardiopulmonary resuscitation (43.2% vs. 42.0%), more arrests in residential locations (77.3% vs. 73.0%) and were less likely to have shockable heart rhythm (23.5% vs. 27.9%). Temporal increases in return of spontaneous circulation and 30-day survival were seen for both groups (return of spontaneous circulation: 8.8% in 2001 to 22.3% in 2014 (diabetes patients) vs. 7.8% in 2001 to 25.7% in 2014 (non-diabetes patients); and 30-day survival: 2.8% in 2001 to 9.7% in 2014 vs. 3.5% to 14.8% in 2014, respectively). In adjusted models, diabetes was associated with decreased odds of return of spontaneous circulation (odds ratio 0.74 (95% confidence interval 0.66-0.82)) and 30-day survival (odds ratio 0.56 (95% confidence interval 0.48-0.65)) (interaction with calendar year p=0.434 and p=0.243, respectively).CONCLUSION:: No significant difference in temporal survival was found between the two groups. However, diabetes was associated with lower odds of return of spontaneous circulation and 30-day survival.
AB - BACKGROUND:: Research regarding out-of-hospital cardiac arrest (OHCA) survival of diabetes patients is sparse and it remains unknown whether initiatives to increase OHCA survival benefit diabetes and non-diabetes patients equally. We therefore examined overall and temporal survival in diabetes and non-diabetes patients following OHCA.METHODS:: Adult presumed cardiac-caused OHCAs were identified from the Danish Cardiac Arrest Registry (2001-2014). Associations between diabetes and return of spontaneous circulation upon hospital arrival and 30-day survival were estimated with logistic regression adjusted for patient- and OHCA-related characteristics.RESULTS:: In total, 28,955 OHCAs were included of which 4276 (14.8%) had diabetes. Compared with non-diabetes patients, diabetes patients had more comorbidities, same prevalence of bystander-witnessed arrests (51.7% vs. 52.7%) and bystander cardiopulmonary resuscitation (43.2% vs. 42.0%), more arrests in residential locations (77.3% vs. 73.0%) and were less likely to have shockable heart rhythm (23.5% vs. 27.9%). Temporal increases in return of spontaneous circulation and 30-day survival were seen for both groups (return of spontaneous circulation: 8.8% in 2001 to 22.3% in 2014 (diabetes patients) vs. 7.8% in 2001 to 25.7% in 2014 (non-diabetes patients); and 30-day survival: 2.8% in 2001 to 9.7% in 2014 vs. 3.5% to 14.8% in 2014, respectively). In adjusted models, diabetes was associated with decreased odds of return of spontaneous circulation (odds ratio 0.74 (95% confidence interval 0.66-0.82)) and 30-day survival (odds ratio 0.56 (95% confidence interval 0.48-0.65)) (interaction with calendar year p=0.434 and p=0.243, respectively).CONCLUSION:: No significant difference in temporal survival was found between the two groups. However, diabetes was associated with lower odds of return of spontaneous circulation and 30-day survival.
U2 - 10.1177/2048872618823349
DO - 10.1177/2048872618823349
M3 - Journal article
C2 - 30632777
VL - 9
SP - 599
EP - 607
JO - European Heart Journal: Acute Cardiovascular Care
JF - European Heart Journal: Acute Cardiovascular Care
SN - 2048-8726
IS - 6
ER -
ID: 234147503