A role for interleukin-33 in T(H)2-polarized intestinal inflammation?
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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A role for interleukin-33 in T(H)2-polarized intestinal inflammation? / Seidelin, J B; Rogler, G; Nielsen, O H.
I: Mucosal Immunology, Bind 4, Nr. 5, 09.2011, s. 496-502.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - A role for interleukin-33 in T(H)2-polarized intestinal inflammation?
AU - Seidelin, J B
AU - Rogler, G
AU - Nielsen, O H
PY - 2011/9
Y1 - 2011/9
N2 - Interleukin 33 (IL-33) is a recently discovered cytokine member of the IL-1 superfamily that is widely expressed in fixed tissue cells, including endothelial and epithelial cells. IL-33 induces helper T cells, mast cells, eosinophils, and basophils to produce type-2 cytokines through binding to the ST2/IL-1 receptor accessory protein complex. Recent studies have shown IL-33 to be upregulated in intestinal parasite infection and in epithelial cells and myofibroblasts in ulcerative colitis (UC). The findings point to a role for IL-33 in directing the T(H)2-type immune responses in these types of mucosal inflammation. As the IL-33/ST2 receptor axis can be manipulated by various blocking antibodies, this could be a potential therapeutic target in the future treatment of UC.
AB - Interleukin 33 (IL-33) is a recently discovered cytokine member of the IL-1 superfamily that is widely expressed in fixed tissue cells, including endothelial and epithelial cells. IL-33 induces helper T cells, mast cells, eosinophils, and basophils to produce type-2 cytokines through binding to the ST2/IL-1 receptor accessory protein complex. Recent studies have shown IL-33 to be upregulated in intestinal parasite infection and in epithelial cells and myofibroblasts in ulcerative colitis (UC). The findings point to a role for IL-33 in directing the T(H)2-type immune responses in these types of mucosal inflammation. As the IL-33/ST2 receptor axis can be manipulated by various blocking antibodies, this could be a potential therapeutic target in the future treatment of UC.
KW - Animals
KW - Colitis, Ulcerative/genetics
KW - Gene Expression Regulation/immunology
KW - Humans
KW - Inflammatory Bowel Diseases/genetics
KW - Interleukin-33
KW - Interleukins/genetics
KW - Intestinal Mucosa/immunology
KW - Receptors, Interleukin-1/metabolism
KW - Signal Transduction/genetics
KW - Th2 Cells/immunology
U2 - 10.1038/mi.2011.22
DO - 10.1038/mi.2011.22
M3 - Review
C2 - 21613987
VL - 4
SP - 496
EP - 502
JO - Mucosal Immunology
JF - Mucosal Immunology
SN - 1933-0219
IS - 5
ER -
ID: 260306498