Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode

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Standard

Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode. / Villagrasa, Ares; Hernandez-Gea, Virginia; Bataller, Ramon; Giraldez, Alvaro; Procopet, Bogdan; Amitrano, Lucio; Villanueva, Candid; Thabut, Dominique; Ibanez-Samaniego, Luis; Albillos, Agustin; Bureau, Christophe; Trebicka, Jonel; Llop, Elba; Laleman, Wim; Palazon, J. M.; Castellote, Jose; Rodrigues, Susana L.; Gluud, Lise N.; Ferreira, Carlos; Canete, Nuria; Rodriguez, Manuel; Ferlitsch, Arnulf L.; Mundi, Jose; Gronbaek, Henning; Hernandez-Guerra, Manuel; Sassatelli, Romano; Dell'Era, Alessandra; Senzolo, Marco G.; Abraldes, Juan; Zipprich, Alexander; Casas, Meritxell; Masnou, Helena; Primignani, Massimo; Krag, Aleksander; Silva-Junior, Gilberto; Romero-Gomez, Manuel; Tantau, Marcel A.; Guardascione, Maria; Alvarado, Edilmar; Rudler, Marika; Banares, Rafael; Martinez, Javier A.; Robic, Marie; Jansen, Christian L.; Calleja, Jose; Nevens, Frederik; Gluud, Lise Lotte; Bosch, Jaime; Ventura-Cots, Meritxell C.; Garcia-Pagan, Juan; Genesca, Joan; Int Variceal Bleeding; Baveno Cooperation.

I: Liver International, Bind 43, Nr. 7, 2023, s. 1548-1557.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Villagrasa, A, Hernandez-Gea, V, Bataller, R, Giraldez, A, Procopet, B, Amitrano, L, Villanueva, C, Thabut, D, Ibanez-Samaniego, L, Albillos, A, Bureau, C, Trebicka, J, Llop, E, Laleman, W, Palazon, JM, Castellote, J, Rodrigues, SL, Gluud, LN, Ferreira, C, Canete, N, Rodriguez, M, Ferlitsch, AL, Mundi, J, Gronbaek, H, Hernandez-Guerra, M, Sassatelli, R, Dell'Era, A, Senzolo, MG, Abraldes, J, Zipprich, A, Casas, M, Masnou, H, Primignani, M, Krag, A, Silva-Junior, G, Romero-Gomez, M, Tantau, MA, Guardascione, M, Alvarado, E, Rudler, M, Banares, R, Martinez, JA, Robic, M, Jansen, CL, Calleja, J, Nevens, F, Gluud, LL, Bosch, J, Ventura-Cots, MC, Garcia-Pagan, J, Genesca, J, Int Variceal Bleeding & Baveno Cooperation 2023, 'Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode', Liver International, bind 43, nr. 7, s. 1548-1557. https://doi.org/10.1111/liv.15606

APA

Villagrasa, A., Hernandez-Gea, V., Bataller, R., Giraldez, A., Procopet, B., Amitrano, L., Villanueva, C., Thabut, D., Ibanez-Samaniego, L., Albillos, A., Bureau, C., Trebicka, J., Llop, E., Laleman, W., Palazon, J. M., Castellote, J., Rodrigues, S. L., Gluud, L. N., Ferreira, C., ... Baveno Cooperation (2023). Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode. Liver International, 43(7), 1548-1557. https://doi.org/10.1111/liv.15606

Vancouver

Villagrasa A, Hernandez-Gea V, Bataller R, Giraldez A, Procopet B, Amitrano L o.a. Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode. Liver International. 2023;43(7):1548-1557. https://doi.org/10.1111/liv.15606

Author

Villagrasa, Ares ; Hernandez-Gea, Virginia ; Bataller, Ramon ; Giraldez, Alvaro ; Procopet, Bogdan ; Amitrano, Lucio ; Villanueva, Candid ; Thabut, Dominique ; Ibanez-Samaniego, Luis ; Albillos, Agustin ; Bureau, Christophe ; Trebicka, Jonel ; Llop, Elba ; Laleman, Wim ; Palazon, J. M. ; Castellote, Jose ; Rodrigues, Susana L. ; Gluud, Lise N. ; Ferreira, Carlos ; Canete, Nuria ; Rodriguez, Manuel ; Ferlitsch, Arnulf L. ; Mundi, Jose ; Gronbaek, Henning ; Hernandez-Guerra, Manuel ; Sassatelli, Romano ; Dell'Era, Alessandra ; Senzolo, Marco G. ; Abraldes, Juan ; Zipprich, Alexander ; Casas, Meritxell ; Masnou, Helena ; Primignani, Massimo ; Krag, Aleksander ; Silva-Junior, Gilberto ; Romero-Gomez, Manuel ; Tantau, Marcel A. ; Guardascione, Maria ; Alvarado, Edilmar ; Rudler, Marika ; Banares, Rafael ; Martinez, Javier A. ; Robic, Marie ; Jansen, Christian L. ; Calleja, Jose ; Nevens, Frederik ; Gluud, Lise Lotte ; Bosch, Jaime ; Ventura-Cots, Meritxell C. ; Garcia-Pagan, Juan ; Genesca, Joan ; Int Variceal Bleeding ; Baveno Cooperation. / Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode. I: Liver International. 2023 ; Bind 43, Nr. 7. s. 1548-1557.

Bibtex

@article{53aa819d638449bc9af072625ee4d99f,
title = "Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode",
abstract = "Background & AimsAlcohol-related hepatitis (AH) encompasses a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis. MethodsMulticentre, observational study including 916 patients with AVB falling under the next categories: AH (n = 99), ALD cirrhosis actively drinking (d-ALD) (n = 285), ALD cirrhosis abstinent from alcohol (a-ALD) (n = 227) and viral cirrhosis (n = 305). We used a Cox proportional hazards model to calculate adjusted hazard ratio (HR) of death adjusted by MELD. ResultsThe prevalence of AH was 16% considering only ALD patients. AH patients exhibited more complications. Forty-two days transplant-free survival was worse among AH, but statistical differences were only observed between AH and d-ALD groups (84 vs. 93%; p = 0.005), when adjusted by MELD no differences were observed between AH and the other groups. At one-year, survival of AH patients (72.7%) was similar to the other groups; when adjusted by MELD mortality HR was better in AH compared to a-ALD (0.48; 0.29-0.8, p = 0.004). Finally, active drinkers who remained abstinent presented better survival, independently of having AH. ConclusionsContrary to expected, AH patients with AVB present no worse one-year survival than other patients with different alcohol-related phenotypes or viral cirrhosis. Abstinence influences long-term survival and could explain these counterintuitive results.",
keywords = "abstinence, alcohol, alcohol-related hepatitis, cirrhosis, upper gastrointestinal bleeding, CIRRHOTIC-PATIENTS, HEPATITIS, ABSTINENCE, PROGNOSIS, MORTALITY",
author = "Ares Villagrasa and Virginia Hernandez-Gea and Ramon Bataller and Alvaro Giraldez and Bogdan Procopet and Lucio Amitrano and Candid Villanueva and Dominique Thabut and Luis Ibanez-Samaniego and Agustin Albillos and Christophe Bureau and Jonel Trebicka and Elba Llop and Wim Laleman and Palazon, {J. M.} and Jose Castellote and Rodrigues, {Susana L.} and Gluud, {Lise N.} and Carlos Ferreira and Nuria Canete and Manuel Rodriguez and Ferlitsch, {Arnulf L.} and Jose Mundi and Henning Gronbaek and Manuel Hernandez-Guerra and Romano Sassatelli and Alessandra Dell'Era and Senzolo, {Marco G.} and Juan Abraldes and Alexander Zipprich and Meritxell Casas and Helena Masnou and Massimo Primignani and Aleksander Krag and Gilberto Silva-Junior and Manuel Romero-Gomez and Tantau, {Marcel A.} and Maria Guardascione and Edilmar Alvarado and Marika Rudler and Rafael Banares and Martinez, {Javier A.} and Marie Robic and Jansen, {Christian L.} and Jose Calleja and Frederik Nevens and Gluud, {Lise Lotte} and Jaime Bosch and Ventura-Cots, {Meritxell C.} and Juan Garcia-Pagan and Joan Genesca and {Int Variceal Bleeding} and {Baveno Cooperation}",
year = "2023",
doi = "10.1111/liv.15606",
language = "English",
volume = "43",
pages = "1548--1557",
journal = "Liver International",
issn = "1478-3223",
publisher = "Wiley-Blackwell",
number = "7",

}

RIS

TY - JOUR

T1 - Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode

AU - Villagrasa, Ares

AU - Hernandez-Gea, Virginia

AU - Bataller, Ramon

AU - Giraldez, Alvaro

AU - Procopet, Bogdan

AU - Amitrano, Lucio

AU - Villanueva, Candid

AU - Thabut, Dominique

AU - Ibanez-Samaniego, Luis

AU - Albillos, Agustin

AU - Bureau, Christophe

AU - Trebicka, Jonel

AU - Llop, Elba

AU - Laleman, Wim

AU - Palazon, J. M.

AU - Castellote, Jose

AU - Rodrigues, Susana L.

AU - Gluud, Lise N.

AU - Ferreira, Carlos

AU - Canete, Nuria

AU - Rodriguez, Manuel

AU - Ferlitsch, Arnulf L.

AU - Mundi, Jose

AU - Gronbaek, Henning

AU - Hernandez-Guerra, Manuel

AU - Sassatelli, Romano

AU - Dell'Era, Alessandra

AU - Senzolo, Marco G.

AU - Abraldes, Juan

AU - Zipprich, Alexander

AU - Casas, Meritxell

AU - Masnou, Helena

AU - Primignani, Massimo

AU - Krag, Aleksander

AU - Silva-Junior, Gilberto

AU - Romero-Gomez, Manuel

AU - Tantau, Marcel A.

AU - Guardascione, Maria

AU - Alvarado, Edilmar

AU - Rudler, Marika

AU - Banares, Rafael

AU - Martinez, Javier A.

AU - Robic, Marie

AU - Jansen, Christian L.

AU - Calleja, Jose

AU - Nevens, Frederik

AU - Gluud, Lise Lotte

AU - Bosch, Jaime

AU - Ventura-Cots, Meritxell C.

AU - Garcia-Pagan, Juan

AU - Genesca, Joan

AU - Int Variceal Bleeding

AU - Baveno Cooperation

PY - 2023

Y1 - 2023

N2 - Background & AimsAlcohol-related hepatitis (AH) encompasses a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis. MethodsMulticentre, observational study including 916 patients with AVB falling under the next categories: AH (n = 99), ALD cirrhosis actively drinking (d-ALD) (n = 285), ALD cirrhosis abstinent from alcohol (a-ALD) (n = 227) and viral cirrhosis (n = 305). We used a Cox proportional hazards model to calculate adjusted hazard ratio (HR) of death adjusted by MELD. ResultsThe prevalence of AH was 16% considering only ALD patients. AH patients exhibited more complications. Forty-two days transplant-free survival was worse among AH, but statistical differences were only observed between AH and d-ALD groups (84 vs. 93%; p = 0.005), when adjusted by MELD no differences were observed between AH and the other groups. At one-year, survival of AH patients (72.7%) was similar to the other groups; when adjusted by MELD mortality HR was better in AH compared to a-ALD (0.48; 0.29-0.8, p = 0.004). Finally, active drinkers who remained abstinent presented better survival, independently of having AH. ConclusionsContrary to expected, AH patients with AVB present no worse one-year survival than other patients with different alcohol-related phenotypes or viral cirrhosis. Abstinence influences long-term survival and could explain these counterintuitive results.

AB - Background & AimsAlcohol-related hepatitis (AH) encompasses a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis. MethodsMulticentre, observational study including 916 patients with AVB falling under the next categories: AH (n = 99), ALD cirrhosis actively drinking (d-ALD) (n = 285), ALD cirrhosis abstinent from alcohol (a-ALD) (n = 227) and viral cirrhosis (n = 305). We used a Cox proportional hazards model to calculate adjusted hazard ratio (HR) of death adjusted by MELD. ResultsThe prevalence of AH was 16% considering only ALD patients. AH patients exhibited more complications. Forty-two days transplant-free survival was worse among AH, but statistical differences were only observed between AH and d-ALD groups (84 vs. 93%; p = 0.005), when adjusted by MELD no differences were observed between AH and the other groups. At one-year, survival of AH patients (72.7%) was similar to the other groups; when adjusted by MELD mortality HR was better in AH compared to a-ALD (0.48; 0.29-0.8, p = 0.004). Finally, active drinkers who remained abstinent presented better survival, independently of having AH. ConclusionsContrary to expected, AH patients with AVB present no worse one-year survival than other patients with different alcohol-related phenotypes or viral cirrhosis. Abstinence influences long-term survival and could explain these counterintuitive results.

KW - abstinence

KW - alcohol

KW - alcohol-related hepatitis

KW - cirrhosis

KW - upper gastrointestinal bleeding

KW - CIRRHOTIC-PATIENTS

KW - HEPATITIS

KW - ABSTINENCE

KW - PROGNOSIS

KW - MORTALITY

U2 - 10.1111/liv.15606

DO - 10.1111/liv.15606

M3 - Journal article

C2 - 37183551

VL - 43

SP - 1548

EP - 1557

JO - Liver International

JF - Liver International

SN - 1478-3223

IS - 7

ER -

ID: 351050417