Infection increases mortality in necrotizing pancreatitis: A systematic review and meta-analysis
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Infection increases mortality in necrotizing pancreatitis : A systematic review and meta-analysis. / Werge, Mikkel; Novovic, Srdjan; Schmidt, Palle N; Gluud, Lise L.
I: Pancreatology, Bind 16, Nr. 5, 2016, s. 698-707.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Infection increases mortality in necrotizing pancreatitis
T2 - A systematic review and meta-analysis
AU - Werge, Mikkel
AU - Novovic, Srdjan
AU - Schmidt, Palle N
AU - Gluud, Lise L
N1 - Copyright © 2016 IAP and EPC. Published by Elsevier B.V. All rights reserved.
PY - 2016
Y1 - 2016
N2 - OBJECTIVES: To assess the influence of infection on mortality in necrotizing pancreatitis.METHODS: Eligible prospective and retrospective studies were identified through manual and electronic searches (August 2015). The risk of bias was assessed using the Newcastle-Ottawa Scale (NOS). Meta-analyses were performed with subgroup, sensitivity, and meta-regression analyses to evaluate sources of heterogeneity.RESULTS: We included 71 studies (n = 6970 patients). Thirty-seven (52%) studies used a prospective design and 25 scored ≥5 points on the NOS suggesting a low risk of bias. Forty studies were descriptive and 31 studies evaluated invasive interventions. In total, 801 of 2842 patients (28%) with infected necroses and 537 of 4128 patients (13%) with sterile necroses died with an odds ratio [OR] of 2.57 (95% confidence interval [CI], 2.00-3.31) based on all studies and 2.02 (95%CI, 1.61-2.53) in the studies with the lowest bias risk. The OR for prospective studies was 2.96 (95%CI, 2.51-3.50). In sensitivity analyses excluding studies evaluating invasive interventions, the OR was 3.30 (95%CI, 2.81-3.88). Patients with infected necrosis and organ failure had a mortality of 35.2% while concomitant sterile necrosis and organ failure was associated with a mortality of 19.8%. If the patients had infected necrosis without organ failure the mortality was 1.4%.CONCLUSIONS: Patients with necrotizing pancreatitis are more than twice as likely to die if the necrosis becomes infected. Both organ failure and infected necrosis increase mortality in necrotizing pancreatitis.
AB - OBJECTIVES: To assess the influence of infection on mortality in necrotizing pancreatitis.METHODS: Eligible prospective and retrospective studies were identified through manual and electronic searches (August 2015). The risk of bias was assessed using the Newcastle-Ottawa Scale (NOS). Meta-analyses were performed with subgroup, sensitivity, and meta-regression analyses to evaluate sources of heterogeneity.RESULTS: We included 71 studies (n = 6970 patients). Thirty-seven (52%) studies used a prospective design and 25 scored ≥5 points on the NOS suggesting a low risk of bias. Forty studies were descriptive and 31 studies evaluated invasive interventions. In total, 801 of 2842 patients (28%) with infected necroses and 537 of 4128 patients (13%) with sterile necroses died with an odds ratio [OR] of 2.57 (95% confidence interval [CI], 2.00-3.31) based on all studies and 2.02 (95%CI, 1.61-2.53) in the studies with the lowest bias risk. The OR for prospective studies was 2.96 (95%CI, 2.51-3.50). In sensitivity analyses excluding studies evaluating invasive interventions, the OR was 3.30 (95%CI, 2.81-3.88). Patients with infected necrosis and organ failure had a mortality of 35.2% while concomitant sterile necrosis and organ failure was associated with a mortality of 19.8%. If the patients had infected necrosis without organ failure the mortality was 1.4%.CONCLUSIONS: Patients with necrotizing pancreatitis are more than twice as likely to die if the necrosis becomes infected. Both organ failure and infected necrosis increase mortality in necrotizing pancreatitis.
KW - Humans
KW - Infection
KW - Multiple Organ Failure
KW - Pancreatitis, Acute Necrotizing
KW - Treatment Outcome
KW - Journal Article
KW - Meta-Analysis
KW - Review
U2 - 10.1016/j.pan.2016.07.004
DO - 10.1016/j.pan.2016.07.004
M3 - Review
C2 - 27449605
VL - 16
SP - 698
EP - 707
JO - Pancreatology
JF - Pancreatology
SN - 1424-3903
IS - 5
ER -
ID: 177483693