PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
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PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis. / Trebicka, Jonel; Fernandez, Javier; Papp, Maria; Caraceni, Paolo; Laleman, Wim; Gambino, Carmine; Giovo, Ilaria; Uschner, Frank Erhard; Jansen, Christian; Jimenez, Cesar; Mookerjee, Rajeshwar; Gustot, Thierry; Albillos, Agustin; Bañares, Rafael; Jarcuska, Peter; Steib, Christian; Reiberger, Thomas; Acevedo, Juan; Gatti, Pietro; Shawcross, Debbie L.; Zeuzem, Stefan; Zipprich, Alexander; Piano, Salvatore; Berg, Thomas; Bruns, Tony; Danielsen, Karen Vagner; Coenraad, Minneke; Merli, Manuela; Stauber, Rudolf; Zoller, Heinz; Ramos, José Presa; Solé, Cristina; Soriano, Germán; de Gottardi, Andrea; Gronbaek, Henning; Saliba, Faouzi; Trautwein, Christian; Kani, Haluk Tarik; Francque, Sven; Ryder, Stephen; Nahon, Pierre; Romero-Gomez, Manuel; Van Vlierberghe, Hans; Francoz, Claire; Manns, Michael; Garcia-Lopez, Elisabet; Tufoni, Manuel; Amoros, Alex; Bendtsen, Flemming; Gluud, Lise Lotte; PREDICT STUDY group of the EASL-CLIF CONSORTIUM.
I: Journal of Hepatology, Bind 74, Nr. 5, 2021, s. 1097-1108.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
AU - Trebicka, Jonel
AU - Fernandez, Javier
AU - Papp, Maria
AU - Caraceni, Paolo
AU - Laleman, Wim
AU - Gambino, Carmine
AU - Giovo, Ilaria
AU - Uschner, Frank Erhard
AU - Jansen, Christian
AU - Jimenez, Cesar
AU - Mookerjee, Rajeshwar
AU - Gustot, Thierry
AU - Albillos, Agustin
AU - Bañares, Rafael
AU - Jarcuska, Peter
AU - Steib, Christian
AU - Reiberger, Thomas
AU - Acevedo, Juan
AU - Gatti, Pietro
AU - Shawcross, Debbie L.
AU - Zeuzem, Stefan
AU - Zipprich, Alexander
AU - Piano, Salvatore
AU - Berg, Thomas
AU - Bruns, Tony
AU - Danielsen, Karen Vagner
AU - Coenraad, Minneke
AU - Merli, Manuela
AU - Stauber, Rudolf
AU - Zoller, Heinz
AU - Ramos, José Presa
AU - Solé, Cristina
AU - Soriano, Germán
AU - de Gottardi, Andrea
AU - Gronbaek, Henning
AU - Saliba, Faouzi
AU - Trautwein, Christian
AU - Kani, Haluk Tarik
AU - Francque, Sven
AU - Ryder, Stephen
AU - Nahon, Pierre
AU - Romero-Gomez, Manuel
AU - Van Vlierberghe, Hans
AU - Francoz, Claire
AU - Manns, Michael
AU - Garcia-Lopez, Elisabet
AU - Tufoni, Manuel
AU - Amoros, Alex
AU - Bendtsen, Flemming
AU - Gluud, Lise Lotte
AU - PREDICT STUDY group of the EASL-CLIF CONSORTIUM
PY - 2021
Y1 - 2021
N2 - Background & Aims: Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading to both of these AD phenotypes. Methods: The multicenter, prospective, observational PREDICT study (NCT03056612) included 1,273 non-electively hospitalized patients with AD (No ACLF = 1,071; ACLF = 202). Medical history, clinical data and laboratory data were collected at enrolment and during 90-day follow-up, with particular attention given to the following characteristics of precipitants: induction of organ dysfunction or failure, systemic inflammation, chronology, intensity, and relationship to outcome. Results: Among various clinical events, 4 distinct events were precipitants consistently related to AD: proven bacterial infections, severe alcoholic hepatitis, gastrointestinal bleeding with shock and toxic encephalopathy. Among patients with precipitants in the AD-No ACLF cohort and the AD-ACLF cohort (38% and 71%, respectively), almost all (96% and 97%, respectively) showed proven bacterial infection and severe alcoholic hepatitis, either alone or in combination with other events. Survival was similar in patients with proven bacterial infections or severe alcoholic hepatitis in both AD phenotypes. The number of precipitants was associated with significantly increased 90-day mortality and was paralleled by increasing levels of surrogates for systemic inflammation. Importantly, adequate first-line antibiotic treatment of proven bacterial infections was associated with a lower ACLF development rate and lower 90-day mortality. Conclusions: This study identified precipitants that are significantly associated with a distinct clinical course and prognosis in patients with AD. Specific preventive and therapeutic strategies targeting these events may improve outcomes in patients with decompensated cirrhosis. Lay summary: Acute decompensation (AD) of cirrhosis is characterized by a rapid deterioration in patient health. Herein, we aimed to analyze the precipitating events that cause AD in patients with cirrhosis. Proven bacterial infections and severe alcoholic hepatitis, either alone or in combination, accounted for almost all (96-97%) cases of AD and acute-on-chronic liver failure. Whilst the type of precipitant was not associated with mortality, the number of precipitant(s) was. This study identified precipitants that are significantly associated with a distinct clinical course and prognosis of patients with AD. Specific preventive and therapeutic strategies targeting these events may improve patient outcomes.
AB - Background & Aims: Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading to both of these AD phenotypes. Methods: The multicenter, prospective, observational PREDICT study (NCT03056612) included 1,273 non-electively hospitalized patients with AD (No ACLF = 1,071; ACLF = 202). Medical history, clinical data and laboratory data were collected at enrolment and during 90-day follow-up, with particular attention given to the following characteristics of precipitants: induction of organ dysfunction or failure, systemic inflammation, chronology, intensity, and relationship to outcome. Results: Among various clinical events, 4 distinct events were precipitants consistently related to AD: proven bacterial infections, severe alcoholic hepatitis, gastrointestinal bleeding with shock and toxic encephalopathy. Among patients with precipitants in the AD-No ACLF cohort and the AD-ACLF cohort (38% and 71%, respectively), almost all (96% and 97%, respectively) showed proven bacterial infection and severe alcoholic hepatitis, either alone or in combination with other events. Survival was similar in patients with proven bacterial infections or severe alcoholic hepatitis in both AD phenotypes. The number of precipitants was associated with significantly increased 90-day mortality and was paralleled by increasing levels of surrogates for systemic inflammation. Importantly, adequate first-line antibiotic treatment of proven bacterial infections was associated with a lower ACLF development rate and lower 90-day mortality. Conclusions: This study identified precipitants that are significantly associated with a distinct clinical course and prognosis in patients with AD. Specific preventive and therapeutic strategies targeting these events may improve outcomes in patients with decompensated cirrhosis. Lay summary: Acute decompensation (AD) of cirrhosis is characterized by a rapid deterioration in patient health. Herein, we aimed to analyze the precipitating events that cause AD in patients with cirrhosis. Proven bacterial infections and severe alcoholic hepatitis, either alone or in combination, accounted for almost all (96-97%) cases of AD and acute-on-chronic liver failure. Whilst the type of precipitant was not associated with mortality, the number of precipitant(s) was. This study identified precipitants that are significantly associated with a distinct clinical course and prognosis of patients with AD. Specific preventive and therapeutic strategies targeting these events may improve patient outcomes.
KW - Acute complications
KW - Chronic liver disease
KW - Non-elective admission
KW - Outcome
KW - Risk factors
U2 - 10.1016/j.jhep.2020.11.019
DO - 10.1016/j.jhep.2020.11.019
M3 - Journal article
C2 - 33227350
AN - SCOPUS:85101877901
VL - 74
SP - 1097
EP - 1108
JO - Journal of Hepatology, Supplement
JF - Journal of Hepatology, Supplement
SN - 0169-5185
IS - 5
ER -
ID: 259105202