Prognosis of patients with ascites after PleurX insertion: an observational study
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Prognosis of patients with ascites after PleurX insertion : an observational study. / Riedel, Agnete Nordheim; Kimer, Nina; Hobolth, Lise; Gluud, Lise Lotte.
I: Scandinavian Journal of Gastroenterology, Bind 53, Nr. 3, 2018, s. 340-344.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Prognosis of patients with ascites after PleurX insertion
T2 - an observational study
AU - Riedel, Agnete Nordheim
AU - Kimer, Nina
AU - Hobolth, Lise
AU - Gluud, Lise Lotte
PY - 2018
Y1 - 2018
N2 - OBJECTIVE: To evaluate the safety of PleurX in cirrhotic patients with refractory ascites.METHODS: We prospectively registered patients who received a PleurX catheter cirrhosis-associated refractory ascites at our department from July 2015 to November 2016. Our control group consisted of matched cirrhotic patients with refractory ascites treated with large volume paracentesis (LVP) and patients with malignant ascites treated with PleurX during the same period.RESULTS: We included 25 patients with cirrhosis-related ascites (7 in PleurX group) and 17 with malignant ascites (14 in PleurX group). Of these, six patients had hepatocellular carcinoma and cirrhosis (5 in PleurX group). None were eligible for insertion of a TIPS or liver transplantation. The maximum duration of follow-up was (480 days) in the PleurX group and 366 days in the LVP group (median 84 and 173 days, respectively). There was no difference in mortality when comparing PleurX with LVP treatment (hazard ratios: 3.0 and 1.0, p = .23 and .96, respectively). Mortality was higher in patients with malignant ascites (p= .01). We found no significant differences in adverse events (incl. spontaneous bacterial peritonitis) or in P-albumin, P-creatinine and P-sodium between the groups.CONCLUSION: PleurX insertion for the treatment of refractory ascites in cirrhotic patients appears to be safe. Prospective randomized trials are necessary in order to confirm these findings.
AB - OBJECTIVE: To evaluate the safety of PleurX in cirrhotic patients with refractory ascites.METHODS: We prospectively registered patients who received a PleurX catheter cirrhosis-associated refractory ascites at our department from July 2015 to November 2016. Our control group consisted of matched cirrhotic patients with refractory ascites treated with large volume paracentesis (LVP) and patients with malignant ascites treated with PleurX during the same period.RESULTS: We included 25 patients with cirrhosis-related ascites (7 in PleurX group) and 17 with malignant ascites (14 in PleurX group). Of these, six patients had hepatocellular carcinoma and cirrhosis (5 in PleurX group). None were eligible for insertion of a TIPS or liver transplantation. The maximum duration of follow-up was (480 days) in the PleurX group and 366 days in the LVP group (median 84 and 173 days, respectively). There was no difference in mortality when comparing PleurX with LVP treatment (hazard ratios: 3.0 and 1.0, p = .23 and .96, respectively). Mortality was higher in patients with malignant ascites (p= .01). We found no significant differences in adverse events (incl. spontaneous bacterial peritonitis) or in P-albumin, P-creatinine and P-sodium between the groups.CONCLUSION: PleurX insertion for the treatment of refractory ascites in cirrhotic patients appears to be safe. Prospective randomized trials are necessary in order to confirm these findings.
KW - Aged
KW - Ascites/etiology
KW - Bacterial Infections/etiology
KW - Carcinoma, Hepatocellular/complications
KW - Catheters, Indwelling/adverse effects
KW - Denmark
KW - Female
KW - Hospitalization/statistics & numerical data
KW - Humans
KW - Liver Cirrhosis/complications
KW - Male
KW - Middle Aged
KW - Paracentesis/adverse effects
KW - Peritonitis/etiology
KW - Prognosis
KW - Prospective Studies
KW - Survival Analysis
KW - Treatment Outcome
U2 - 10.1080/00365521.2018.1436190
DO - 10.1080/00365521.2018.1436190
M3 - Journal article
C2 - 29411667
VL - 53
SP - 340
EP - 344
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
SN - 0036-5521
IS - 3
ER -
ID: 213162016