Spontaneous T-cell responses against the immune check point programmed-death-ligand 1 (PD-L1) in patients with chronic myeloproliferative neoplasms correlate with disease stage and clinical response
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The Chronic Myeloproliferative Neoplasms (MPN) are cancers characterized by hyperinflammation and immune deregulation. Concurrently, the expression of the immune check point programmed death ligand 1 (PD-L1) is induced by inflammation. In this study we report on the occurrence of spontaneous T cell responses against a PD-L1 derived epitope in patients with MPN. We show that 71% of patients display a significant immune response against PD-L1, and patients with advanced MPN have significantly fewer and weaker PD-L1 specific immune responses compared to patients with non-advanced MPN. The PD-L1 specific T cell responses are CD4+ T cell responses, and by gene expression analysis we show that expression of PD-L1 is enhanced in patients with MPN. This could imply that the tumor specific immune response in MPN could be enhanced by vaccination with PD-L1 derived epitopes by boosting the anti-regulatory immune response hereby allowing tumor specific T cell to exert anti-tumor immunity.
Originalsprog | Engelsk |
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Artikelnummer | e1433521 |
Tidsskrift | OncoImmunology |
Vol/bind | 7 |
Udgave nummer | 6 |
ISSN | 2162-4011 |
DOI | |
Status | Udgivet - 2018 |
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980374/pdf/koni-07-06-1433521.pdf
Forlagets udgivne version
ID: 193298422