Exercise and education vs intra-articular saline for knee osteoarthritis: a 1-year follow-up of a randomized trial
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Objective: To assess the longer-term effect of the Good Life with osteoarthritis in Denmark (GLAD) exercise and education program relative to open-label placebo (OLP) on changes from baseline in core outcomes in individuals with knee osteoarthritis (OA). Methods: In this 1-year follow-up of an open-label, randomized trial, patients with symptomatic and radiographically confirmed knee OA were monitored after being randomized to either the 8-week GLAD program or OLP given as 4 intra-articular saline injections over 8 weeks. The primary outcome was the change from baseline in the Knee injury and Osteoarthritis Outcome Score questionnaire (KOOS) pain subscale after 1 year in the intention-to-treat population. Key secondary outcomes were the KOOS function and quality of life subscales, and Patients' Global Assessment of disease impact. Results: 206 adults were randomly assigned: 102 to GLAD and 104 to OLP, of which only 137 (63/74 GLAD/OLP) provided data at 1 year. At one year the mean changes in KOOS pain were 8.4 for GLAD and 7.0 for OLP (Difference: 1.5 points; 95% CI −2.6 to 5.5). There were no between-group differences in any of the secondary outcomes. Conclusions: In this 1-year follow-up of individuals with knee OA, the 8-week GLAD program and OLP both provided minor longer-term benefits with no group difference. These results require confirmation given the significant loss to follow-up. Trial registration number: NCT03843931.
Originalsprog | Engelsk |
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Tidsskrift | Osteoarthritis and Cartilage |
Vol/bind | 31 |
Udgave nummer | 5 |
Sider (fra-til) | 627-635 |
Antal sider | 9 |
ISSN | 1063-4584 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
This study was supported by grants from The Lundbeck Foundation , The Danish Physiotherapists Association , and Aase og Ejnar Danielsens Fund . The Parker Institute, Bispebjerg and Frederiksberg Hospital, is supported by a core grant from the Oak Foundation ( OCAY-18-774-OFIL ).
Publisher Copyright:
© 2023 The Author(s)
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