11q13 is a Susceptibility Locus for Hormone Receptor Positive Breast Cancer
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11q13 is a Susceptibility Locus for Hormone Receptor Positive Breast Cancer. / Lambrechts, Diether; Truong, Therese; Justenhoven, Christina; Humphreys, Manjeet K; Wang, Jean; Hopper, John L; Dite, Gillian S; Apicella, Carmel; Southey, Melissa C; Schmidt, Marjanka K; Broeks, Annegien; Cornelissen, Sten; Hien, Richard van; Sawyer, Elinor; Tomlinson, Ian; Kerin, Michael; Miller, Nicola; Milne, Roger L; Zamora, M Pilar; Pérez, José Ignacio Arias; Benítez, Javier; Hamann, Ute; Ko, Yon-Dschun; Brüning, Thomas; Chang-Claude, Jenny; Eilber, Ursel; Hein, Rebecca; Nickels, Stefan; Flesch-Janys, Dieter; Wang-Gohrke, Shan; John, Esther M; Miron, Alexander; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Chenevix-Trench, Georgia; Beesley, Jonathan; Chen, Xiaoqing; Menegaux, Florence; Cordina-Duverger, Emilie; Shen, Chen-Yang; Yu, Jyh-Cherng; Wu, Pei-Ei; Hou, Ming-Feng; Andrulis, Irene L; Selander, Teresa; Nordestgaard, Børge G; Bojesen, Stig E; Lanng, Charlotte; The GENICA Network.
I: Human Mutation, 2012.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - 11q13 is a Susceptibility Locus for Hormone Receptor Positive Breast Cancer
AU - Lambrechts, Diether
AU - Truong, Therese
AU - Justenhoven, Christina
AU - Humphreys, Manjeet K
AU - Wang, Jean
AU - Hopper, John L
AU - Dite, Gillian S
AU - Apicella, Carmel
AU - Southey, Melissa C
AU - Schmidt, Marjanka K
AU - Broeks, Annegien
AU - Cornelissen, Sten
AU - Hien, Richard van
AU - Sawyer, Elinor
AU - Tomlinson, Ian
AU - Kerin, Michael
AU - Miller, Nicola
AU - Milne, Roger L
AU - Zamora, M Pilar
AU - Pérez, José Ignacio Arias
AU - Benítez, Javier
AU - Hamann, Ute
AU - Ko, Yon-Dschun
AU - Brüning, Thomas
AU - Chang-Claude, Jenny
AU - Eilber, Ursel
AU - Hein, Rebecca
AU - Nickels, Stefan
AU - Flesch-Janys, Dieter
AU - Wang-Gohrke, Shan
AU - John, Esther M
AU - Miron, Alexander
AU - Winqvist, Robert
AU - Pylkäs, Katri
AU - Jukkola-Vuorinen, Arja
AU - Grip, Mervi
AU - Chenevix-Trench, Georgia
AU - Beesley, Jonathan
AU - Chen, Xiaoqing
AU - Menegaux, Florence
AU - Cordina-Duverger, Emilie
AU - Shen, Chen-Yang
AU - Yu, Jyh-Cherng
AU - Wu, Pei-Ei
AU - Hou, Ming-Feng
AU - Andrulis, Irene L
AU - Selander, Teresa
AU - Nordestgaard, Børge G
AU - Bojesen, Stig E
AU - Lanng, Charlotte
AU - The GENICA Network
N1 - © 2012 Wiley Periodicals, Inc.
PY - 2012
Y1 - 2012
N2 - A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10 and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P = 3 × 10-9) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 × 10-39). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype.
AB - A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10 and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P = 3 × 10-9) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 × 10-39). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype.
U2 - 10.1002/humu.22089
DO - 10.1002/humu.22089
M3 - Journal article
C2 - 22461340
JO - Human Mutation
JF - Human Mutation
SN - 1059-7794
ER -
ID: 40173958