A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry

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A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry. / Middha, Pooja; Wang, Xiaoliang; Behrens, Sabine; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Michailidou, Kyriaki; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Arndt, Volker; Aronson, Kristan J.; Auer, Paul L.; Augustinsson, Annelie; Baert, Thaïs; Freeman, Laura E.Beane; Becher, Heiko; Beckmann, Matthias W.; Benitez, Javier; Bojesen, Stig E.; Brauch, Hiltrud; Brenner, Hermann; Brooks-Wilson, Angela; Campa, Daniele; Canzian, Federico; Carracedo, Angel; Castelao, Jose E.; Chanock, Stephen J.; Chenevix-Trench, Georgia; Cordina-Duverger, Emilie; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Czene, Kamila; Dossus, Laure; Dugué, Pierre Antoine; Eliassen, A. Heather; Eriksson, Mikael; Evans, D. Gareth; Fasching, Peter A.; Figueroa, Jonine D.; Fletcher, Olivia; Flyger, Henrik; Gabrielson, Marike; Gago-Dominguez, Manuela; Giles, Graham G.; González-Neira, Anna; Grassmann, Felix; Nielsen, Sune F.; Nordestgaard, Børge G.; CTS Consortium; ABCTB Investigators; kConFab Investigators.

I: Breast cancer research : BCR, Bind 25, Nr. 1, 93, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Middha, P, Wang, X, Behrens, S, Bolla, MK, Wang, Q, Dennis, J, Michailidou, K, Ahearn, TU, Andrulis, IL, Anton-Culver, H, Arndt, V, Aronson, KJ, Auer, PL, Augustinsson, A, Baert, T, Freeman, LEB, Becher, H, Beckmann, MW, Benitez, J, Bojesen, SE, Brauch, H, Brenner, H, Brooks-Wilson, A, Campa, D, Canzian, F, Carracedo, A, Castelao, JE, Chanock, SJ, Chenevix-Trench, G, Cordina-Duverger, E, Couch, FJ, Cox, A, Cross, SS, Czene, K, Dossus, L, Dugué, PA, Eliassen, AH, Eriksson, M, Evans, DG, Fasching, PA, Figueroa, JD, Fletcher, O, Flyger, H, Gabrielson, M, Gago-Dominguez, M, Giles, GG, González-Neira, A, Grassmann, F, Nielsen, SF, Nordestgaard, BG, CTS Consortium, ABCTB Investigators & kConFab Investigators 2023, 'A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry', Breast cancer research : BCR, bind 25, nr. 1, 93. https://doi.org/10.1186/s13058-023-01691-8

APA

Middha, P., Wang, X., Behrens, S., Bolla, M. K., Wang, Q., Dennis, J., Michailidou, K., Ahearn, T. U., Andrulis, I. L., Anton-Culver, H., Arndt, V., Aronson, K. J., Auer, P. L., Augustinsson, A., Baert, T., Freeman, L. E. B., Becher, H., Beckmann, M. W., Benitez, J., ... kConFab Investigators (2023). A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry. Breast cancer research : BCR, 25(1), [93]. https://doi.org/10.1186/s13058-023-01691-8

Vancouver

Middha P, Wang X, Behrens S, Bolla MK, Wang Q, Dennis J o.a. A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry. Breast cancer research : BCR. 2023;25(1). 93. https://doi.org/10.1186/s13058-023-01691-8

Author

Middha, Pooja ; Wang, Xiaoliang ; Behrens, Sabine ; Bolla, Manjeet K. ; Wang, Qin ; Dennis, Joe ; Michailidou, Kyriaki ; Ahearn, Thomas U. ; Andrulis, Irene L. ; Anton-Culver, Hoda ; Arndt, Volker ; Aronson, Kristan J. ; Auer, Paul L. ; Augustinsson, Annelie ; Baert, Thaïs ; Freeman, Laura E.Beane ; Becher, Heiko ; Beckmann, Matthias W. ; Benitez, Javier ; Bojesen, Stig E. ; Brauch, Hiltrud ; Brenner, Hermann ; Brooks-Wilson, Angela ; Campa, Daniele ; Canzian, Federico ; Carracedo, Angel ; Castelao, Jose E. ; Chanock, Stephen J. ; Chenevix-Trench, Georgia ; Cordina-Duverger, Emilie ; Couch, Fergus J. ; Cox, Angela ; Cross, Simon S. ; Czene, Kamila ; Dossus, Laure ; Dugué, Pierre Antoine ; Eliassen, A. Heather ; Eriksson, Mikael ; Evans, D. Gareth ; Fasching, Peter A. ; Figueroa, Jonine D. ; Fletcher, Olivia ; Flyger, Henrik ; Gabrielson, Marike ; Gago-Dominguez, Manuela ; Giles, Graham G. ; González-Neira, Anna ; Grassmann, Felix ; Nielsen, Sune F. ; Nordestgaard, Børge G. ; CTS Consortium ; ABCTB Investigators ; kConFab Investigators. / A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry. I: Breast cancer research : BCR. 2023 ; Bind 25, Nr. 1.

Bibtex

@article{0c6a461bd4d84890b4fcebe6f62099a5,
title = "A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry",
abstract = "BACKGROUND: Genome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer. METHODS: Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs. RESULTS: Assuming a 1 × 10-5 prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability < 15%, we identified two independent SNP-risk factor pairs: rs80018847(9p13)-LINGO2 and adult height in association with overall breast cancer risk (ORint = 0.94, 95% CI 0.92-0.96), and rs4770552(13q12)-SPATA13 and age at menarche for ER + breast cancer risk (ORint = 0.91, 95% CI 0.88-0.94). CONCLUSIONS: Overall, the contribution of G×E interactions to the heritability of breast cancer is very small. At the population level, multiplicative G×E interactions do not make an important contribution to risk prediction in breast cancer.",
keywords = "Breast cancer, European ancestry, Gene-environment interactions, Genetic epidemiology",
author = "Pooja Middha and Xiaoliang Wang and Sabine Behrens and Bolla, {Manjeet K.} and Qin Wang and Joe Dennis and Kyriaki Michailidou and Ahearn, {Thomas U.} and Andrulis, {Irene L.} and Hoda Anton-Culver and Volker Arndt and Aronson, {Kristan J.} and Auer, {Paul L.} and Annelie Augustinsson and Tha{\"i}s Baert and Freeman, {Laura E.Beane} and Heiko Becher and Beckmann, {Matthias W.} and Javier Benitez and Bojesen, {Stig E.} and Hiltrud Brauch and Hermann Brenner and Angela Brooks-Wilson and Daniele Campa and Federico Canzian and Angel Carracedo and Castelao, {Jose E.} and Chanock, {Stephen J.} and Georgia Chenevix-Trench and Emilie Cordina-Duverger and Couch, {Fergus J.} and Angela Cox and Cross, {Simon S.} and Kamila Czene and Laure Dossus and Dugu{\'e}, {Pierre Antoine} and Eliassen, {A. Heather} and Mikael Eriksson and Evans, {D. Gareth} and Fasching, {Peter A.} and Figueroa, {Jonine D.} and Olivia Fletcher and Henrik Flyger and Marike Gabrielson and Manuela Gago-Dominguez and Giles, {Graham G.} and Anna Gonz{\'a}lez-Neira and Felix Grassmann and Nielsen, {Sune F.} and Nordestgaard, {B{\o}rge G.} and {CTS Consortium} and {ABCTB Investigators} and {kConFab Investigators}",
note = "Publisher Copyright: {\textcopyright} 2023. BioMed Central Ltd., part of Springer Nature.",
year = "2023",
doi = "10.1186/s13058-023-01691-8",
language = "English",
volume = "25",
journal = "Breast Cancer Research",
issn = "1465-5411",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry

AU - Middha, Pooja

AU - Wang, Xiaoliang

AU - Behrens, Sabine

AU - Bolla, Manjeet K.

AU - Wang, Qin

AU - Dennis, Joe

AU - Michailidou, Kyriaki

AU - Ahearn, Thomas U.

AU - Andrulis, Irene L.

AU - Anton-Culver, Hoda

AU - Arndt, Volker

AU - Aronson, Kristan J.

AU - Auer, Paul L.

AU - Augustinsson, Annelie

AU - Baert, Thaïs

AU - Freeman, Laura E.Beane

AU - Becher, Heiko

AU - Beckmann, Matthias W.

AU - Benitez, Javier

AU - Bojesen, Stig E.

AU - Brauch, Hiltrud

AU - Brenner, Hermann

AU - Brooks-Wilson, Angela

AU - Campa, Daniele

AU - Canzian, Federico

AU - Carracedo, Angel

AU - Castelao, Jose E.

AU - Chanock, Stephen J.

AU - Chenevix-Trench, Georgia

AU - Cordina-Duverger, Emilie

AU - Couch, Fergus J.

AU - Cox, Angela

AU - Cross, Simon S.

AU - Czene, Kamila

AU - Dossus, Laure

AU - Dugué, Pierre Antoine

AU - Eliassen, A. Heather

AU - Eriksson, Mikael

AU - Evans, D. Gareth

AU - Fasching, Peter A.

AU - Figueroa, Jonine D.

AU - Fletcher, Olivia

AU - Flyger, Henrik

AU - Gabrielson, Marike

AU - Gago-Dominguez, Manuela

AU - Giles, Graham G.

AU - González-Neira, Anna

AU - Grassmann, Felix

AU - Nielsen, Sune F.

AU - Nordestgaard, Børge G.

AU - CTS Consortium

AU - ABCTB Investigators

AU - kConFab Investigators

N1 - Publisher Copyright: © 2023. BioMed Central Ltd., part of Springer Nature.

PY - 2023

Y1 - 2023

N2 - BACKGROUND: Genome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer. METHODS: Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs. RESULTS: Assuming a 1 × 10-5 prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability < 15%, we identified two independent SNP-risk factor pairs: rs80018847(9p13)-LINGO2 and adult height in association with overall breast cancer risk (ORint = 0.94, 95% CI 0.92-0.96), and rs4770552(13q12)-SPATA13 and age at menarche for ER + breast cancer risk (ORint = 0.91, 95% CI 0.88-0.94). CONCLUSIONS: Overall, the contribution of G×E interactions to the heritability of breast cancer is very small. At the population level, multiplicative G×E interactions do not make an important contribution to risk prediction in breast cancer.

AB - BACKGROUND: Genome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer. METHODS: Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs. RESULTS: Assuming a 1 × 10-5 prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability < 15%, we identified two independent SNP-risk factor pairs: rs80018847(9p13)-LINGO2 and adult height in association with overall breast cancer risk (ORint = 0.94, 95% CI 0.92-0.96), and rs4770552(13q12)-SPATA13 and age at menarche for ER + breast cancer risk (ORint = 0.91, 95% CI 0.88-0.94). CONCLUSIONS: Overall, the contribution of G×E interactions to the heritability of breast cancer is very small. At the population level, multiplicative G×E interactions do not make an important contribution to risk prediction in breast cancer.

KW - Breast cancer

KW - European ancestry

KW - Gene-environment interactions

KW - Genetic epidemiology

U2 - 10.1186/s13058-023-01691-8

DO - 10.1186/s13058-023-01691-8

M3 - Journal article

C2 - 37559094

AN - SCOPUS:85167531154

VL - 25

JO - Breast Cancer Research

JF - Breast Cancer Research

SN - 1465-5411

IS - 1

M1 - 93

ER -

ID: 362738798