Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. / Wang, Anqi; Shen, Jiayi; Rodriguez, Alex A.; Saunders, Edward J.; Chen, Fei; Janivara, Rohini; Darst, Burcu F.; Sheng, Xin; Xu, Yili; Chou, Alisha J.; Benlloch, Sara; Dadaev, Tokhir; Brook, Mark N.; Plym, Anna; Sahimi, Ali; Hoffman, Thomas J.; Takahashi, Atushi; Matsuda, Koichi; Momozawa, Yukihide; Fujita, Masashi; Laisk, Triin; Figuerêdo, Jéssica; Muir, Kenneth; Ito, Shuji; Liu, Xiaoxi; Yamanashi, Yuji; Furukawa, Yoichi; Morisaki, Takayuki; Murakami, Yoshinori; Muto, Kaori; Nagai, Akiko; Obara, Wataru; Yamaji, Ken; Takahashi, Kazuhisa; Asai, Satoshi; Takahashi, Yasuo; Suzuki, Takao; Sinozaki, Nobuaki; Yamaguchi, Hiroki; Nordestgaard, Borge G.; Nielsen, Sune F.; Weischer, Maren; Bojesen, Stig E.; Røder, Andreas; Stroomberg, Hein V.; Sørensen, Karina Dalsgaard; Borre, Michael; Strom, Sara S.; Wang, Ying; Loos, Ruth J.F.; The Biobank Japan Project.

I: Nature Genetics, Bind 55, Nr. 12, 2023, s. 2065-2074.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Wang, A, Shen, J, Rodriguez, AA, Saunders, EJ, Chen, F, Janivara, R, Darst, BF, Sheng, X, Xu, Y, Chou, AJ, Benlloch, S, Dadaev, T, Brook, MN, Plym, A, Sahimi, A, Hoffman, TJ, Takahashi, A, Matsuda, K, Momozawa, Y, Fujita, M, Laisk, T, Figuerêdo, J, Muir, K, Ito, S, Liu, X, Yamanashi, Y, Furukawa, Y, Morisaki, T, Murakami, Y, Muto, K, Nagai, A, Obara, W, Yamaji, K, Takahashi, K, Asai, S, Takahashi, Y, Suzuki, T, Sinozaki, N, Yamaguchi, H, Nordestgaard, BG, Nielsen, SF, Weischer, M, Bojesen, SE, Røder, A, Stroomberg, HV, Sørensen, KD, Borre, M, Strom, SS, Wang, Y, Loos, RJF & The Biobank Japan Project 2023, 'Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants', Nature Genetics, bind 55, nr. 12, s. 2065-2074. https://doi.org/10.1038/s41588-023-01534-4

APA

Wang, A., Shen, J., Rodriguez, A. A., Saunders, E. J., Chen, F., Janivara, R., Darst, B. F., Sheng, X., Xu, Y., Chou, A. J., Benlloch, S., Dadaev, T., Brook, M. N., Plym, A., Sahimi, A., Hoffman, T. J., Takahashi, A., Matsuda, K., Momozawa, Y., ... The Biobank Japan Project (2023). Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. Nature Genetics, 55(12), 2065-2074. https://doi.org/10.1038/s41588-023-01534-4

Vancouver

Wang A, Shen J, Rodriguez AA, Saunders EJ, Chen F, Janivara R o.a. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. Nature Genetics. 2023;55(12):2065-2074. https://doi.org/10.1038/s41588-023-01534-4

Author

Wang, Anqi ; Shen, Jiayi ; Rodriguez, Alex A. ; Saunders, Edward J. ; Chen, Fei ; Janivara, Rohini ; Darst, Burcu F. ; Sheng, Xin ; Xu, Yili ; Chou, Alisha J. ; Benlloch, Sara ; Dadaev, Tokhir ; Brook, Mark N. ; Plym, Anna ; Sahimi, Ali ; Hoffman, Thomas J. ; Takahashi, Atushi ; Matsuda, Koichi ; Momozawa, Yukihide ; Fujita, Masashi ; Laisk, Triin ; Figuerêdo, Jéssica ; Muir, Kenneth ; Ito, Shuji ; Liu, Xiaoxi ; Yamanashi, Yuji ; Furukawa, Yoichi ; Morisaki, Takayuki ; Murakami, Yoshinori ; Muto, Kaori ; Nagai, Akiko ; Obara, Wataru ; Yamaji, Ken ; Takahashi, Kazuhisa ; Asai, Satoshi ; Takahashi, Yasuo ; Suzuki, Takao ; Sinozaki, Nobuaki ; Yamaguchi, Hiroki ; Nordestgaard, Borge G. ; Nielsen, Sune F. ; Weischer, Maren ; Bojesen, Stig E. ; Røder, Andreas ; Stroomberg, Hein V. ; Sørensen, Karina Dalsgaard ; Borre, Michael ; Strom, Sara S. ; Wang, Ying ; Loos, Ruth J.F. ; The Biobank Japan Project. / Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. I: Nature Genetics. 2023 ; Bind 55, Nr. 12. s. 2065-2074.

Bibtex

@article{a6b6c0b1b17743058d6ef5ead4475156,
title = "Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants",
abstract = "The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.",
author = "Anqi Wang and Jiayi Shen and Rodriguez, {Alex A.} and Saunders, {Edward J.} and Fei Chen and Rohini Janivara and Darst, {Burcu F.} and Xin Sheng and Yili Xu and Chou, {Alisha J.} and Sara Benlloch and Tokhir Dadaev and Brook, {Mark N.} and Anna Plym and Ali Sahimi and Hoffman, {Thomas J.} and Atushi Takahashi and Koichi Matsuda and Yukihide Momozawa and Masashi Fujita and Triin Laisk and J{\'e}ssica Figuer{\^e}do and Kenneth Muir and Shuji Ito and Xiaoxi Liu and Yuji Yamanashi and Yoichi Furukawa and Takayuki Morisaki and Yoshinori Murakami and Kaori Muto and Akiko Nagai and Wataru Obara and Ken Yamaji and Kazuhisa Takahashi and Satoshi Asai and Yasuo Takahashi and Takao Suzuki and Nobuaki Sinozaki and Hiroki Yamaguchi and Nordestgaard, {Borge G.} and Nielsen, {Sune F.} and Maren Weischer and Bojesen, {Stig E.} and Andreas R{\o}der and Stroomberg, {Hein V.} and S{\o}rensen, {Karina Dalsgaard} and Michael Borre and Strom, {Sara S.} and Ying Wang and Loos, {Ruth J.F.} and {The Biobank Japan Project}",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2023",
doi = "10.1038/s41588-023-01534-4",
language = "English",
volume = "55",
pages = "2065--2074",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "12",

}

RIS

TY - JOUR

T1 - Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

AU - Wang, Anqi

AU - Shen, Jiayi

AU - Rodriguez, Alex A.

AU - Saunders, Edward J.

AU - Chen, Fei

AU - Janivara, Rohini

AU - Darst, Burcu F.

AU - Sheng, Xin

AU - Xu, Yili

AU - Chou, Alisha J.

AU - Benlloch, Sara

AU - Dadaev, Tokhir

AU - Brook, Mark N.

AU - Plym, Anna

AU - Sahimi, Ali

AU - Hoffman, Thomas J.

AU - Takahashi, Atushi

AU - Matsuda, Koichi

AU - Momozawa, Yukihide

AU - Fujita, Masashi

AU - Laisk, Triin

AU - Figuerêdo, Jéssica

AU - Muir, Kenneth

AU - Ito, Shuji

AU - Liu, Xiaoxi

AU - Yamanashi, Yuji

AU - Furukawa, Yoichi

AU - Morisaki, Takayuki

AU - Murakami, Yoshinori

AU - Muto, Kaori

AU - Nagai, Akiko

AU - Obara, Wataru

AU - Yamaji, Ken

AU - Takahashi, Kazuhisa

AU - Asai, Satoshi

AU - Takahashi, Yasuo

AU - Suzuki, Takao

AU - Sinozaki, Nobuaki

AU - Yamaguchi, Hiroki

AU - Nordestgaard, Borge G.

AU - Nielsen, Sune F.

AU - Weischer, Maren

AU - Bojesen, Stig E.

AU - Røder, Andreas

AU - Stroomberg, Hein V.

AU - Sørensen, Karina Dalsgaard

AU - Borre, Michael

AU - Strom, Sara S.

AU - Wang, Ying

AU - Loos, Ruth J.F.

AU - The Biobank Japan Project

N1 - Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.

PY - 2023

Y1 - 2023

N2 - The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.

AB - The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.

U2 - 10.1038/s41588-023-01534-4

DO - 10.1038/s41588-023-01534-4

M3 - Journal article

C2 - 37945903

AN - SCOPUS:85176259299

VL - 55

SP - 2065

EP - 2074

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 12

ER -

ID: 377987952