Coronary artery- and aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms

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Standard

Coronary artery- and aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms. / Solli, Camilla Nordheim; Chamat-Hedemand, Sandra; Elming, Hanne; Ngo, Anh; Kjær, Lasse; Skov, Vibe; Sørensen, Anders Lindholm; Ellervik, Christina; Fuchs, Andreas; Sigvardsen, Per Ejlstrup; Kühl, Jørgen Tobias; Kofoed, Klaus Fuglsang; Nordestgaard, Børge G.; Hasselbalch, Hans; Bruun, Niels Eske.

I: International Journal of Cardiology, Bind 364, 2022, s. 112-118.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Solli, CN, Chamat-Hedemand, S, Elming, H, Ngo, A, Kjær, L, Skov, V, Sørensen, AL, Ellervik, C, Fuchs, A, Sigvardsen, PE, Kühl, JT, Kofoed, KF, Nordestgaard, BG, Hasselbalch, H & Bruun, NE 2022, 'Coronary artery- and aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms', International Journal of Cardiology, bind 364, s. 112-118. https://doi.org/10.1016/j.ijcard.2022.06.029

APA

Solli, C. N., Chamat-Hedemand, S., Elming, H., Ngo, A., Kjær, L., Skov, V., Sørensen, A. L., Ellervik, C., Fuchs, A., Sigvardsen, P. E., Kühl, J. T., Kofoed, K. F., Nordestgaard, B. G., Hasselbalch, H., & Bruun, N. E. (2022). Coronary artery- and aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms. International Journal of Cardiology, 364, 112-118. https://doi.org/10.1016/j.ijcard.2022.06.029

Vancouver

Solli CN, Chamat-Hedemand S, Elming H, Ngo A, Kjær L, Skov V o.a. Coronary artery- and aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms. International Journal of Cardiology. 2022;364:112-118. https://doi.org/10.1016/j.ijcard.2022.06.029

Author

Solli, Camilla Nordheim ; Chamat-Hedemand, Sandra ; Elming, Hanne ; Ngo, Anh ; Kjær, Lasse ; Skov, Vibe ; Sørensen, Anders Lindholm ; Ellervik, Christina ; Fuchs, Andreas ; Sigvardsen, Per Ejlstrup ; Kühl, Jørgen Tobias ; Kofoed, Klaus Fuglsang ; Nordestgaard, Børge G. ; Hasselbalch, Hans ; Bruun, Niels Eske. / Coronary artery- and aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms. I: International Journal of Cardiology. 2022 ; Bind 364. s. 112-118.

Bibtex

@article{a1d2467729254b168025f81f380db018,
title = "Coronary artery- and aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms",
abstract = "Background: Patients with the hematological cancers Philadelphia-negative Myeloproliferative Neoplasms (MPNs) have an increased risk of cardiovascular disease. However, whether MPNs have an increased burden of cardiac calcification has not been thoroughly investigated. Our aim is to investigate whether patients with MPNs have an increased burden of cardiac calcification that could help explain their increased risk of cardiovascular disease. Methods and results: We recruited 161 patients (mean age 65 years, 52% men) with an MPN diagnosis between 2016 and 2018. Coronary artery calcium score (CACS) and aortic valve calcification (AVC) were measured by cardiac computer tomography, and detailed information on cardiovascular risk factors was recorded. MPNs were matched on age and sex, with 805 controls from the Copenhagen General Population Study. A CACS>400 was present in 26% of MPNs and 19% of controls (p = 0.031). AVC was present in 58% of MPNs and 34% of controls (p < 0.0001). After adjustment for cardiovascular risk factors, the odds ratio (OR) of a CACS>400 was 1.9 (95% CI 1.2–3.1, p = 0.008) in MPNs compared to controls, and the OR of AVC was 4.4 (95% CI 2.9–6.9, p < 0.0001) in MPNs compared to controls. Conclusion: Patients with MPNs have a significantly higher prevalence of a CACS >400 and AVC, compared to controls from the general population. The association between MPN and a CACS>400 or AVC remains significant after adjustment for cardiovascular risk factors. These novel data support the hypothesis that MPNs have an increased burden of cardiac calcifications, independent of other cardiovascular risk factors.",
keywords = "Aortic valve disease, Atherosclerosis, Cardiovascular diseases, Coronary artery disease, Multidetector computed tomography, Myeloproliferative disorders",
author = "Solli, {Camilla Nordheim} and Sandra Chamat-Hedemand and Hanne Elming and Anh Ngo and Lasse Kj{\ae}r and Vibe Skov and S{\o}rensen, {Anders Lindholm} and Christina Ellervik and Andreas Fuchs and Sigvardsen, {Per Ejlstrup} and K{\"u}hl, {J{\o}rgen Tobias} and Kofoed, {Klaus Fuglsang} and Nordestgaard, {B{\o}rge G.} and Hans Hasselbalch and Bruun, {Niels Eske}",
note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
doi = "10.1016/j.ijcard.2022.06.029",
language = "English",
volume = "364",
pages = "112--118",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Coronary artery- and aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms

AU - Solli, Camilla Nordheim

AU - Chamat-Hedemand, Sandra

AU - Elming, Hanne

AU - Ngo, Anh

AU - Kjær, Lasse

AU - Skov, Vibe

AU - Sørensen, Anders Lindholm

AU - Ellervik, Christina

AU - Fuchs, Andreas

AU - Sigvardsen, Per Ejlstrup

AU - Kühl, Jørgen Tobias

AU - Kofoed, Klaus Fuglsang

AU - Nordestgaard, Børge G.

AU - Hasselbalch, Hans

AU - Bruun, Niels Eske

N1 - Publisher Copyright: © 2022 The Author(s)

PY - 2022

Y1 - 2022

N2 - Background: Patients with the hematological cancers Philadelphia-negative Myeloproliferative Neoplasms (MPNs) have an increased risk of cardiovascular disease. However, whether MPNs have an increased burden of cardiac calcification has not been thoroughly investigated. Our aim is to investigate whether patients with MPNs have an increased burden of cardiac calcification that could help explain their increased risk of cardiovascular disease. Methods and results: We recruited 161 patients (mean age 65 years, 52% men) with an MPN diagnosis between 2016 and 2018. Coronary artery calcium score (CACS) and aortic valve calcification (AVC) were measured by cardiac computer tomography, and detailed information on cardiovascular risk factors was recorded. MPNs were matched on age and sex, with 805 controls from the Copenhagen General Population Study. A CACS>400 was present in 26% of MPNs and 19% of controls (p = 0.031). AVC was present in 58% of MPNs and 34% of controls (p < 0.0001). After adjustment for cardiovascular risk factors, the odds ratio (OR) of a CACS>400 was 1.9 (95% CI 1.2–3.1, p = 0.008) in MPNs compared to controls, and the OR of AVC was 4.4 (95% CI 2.9–6.9, p < 0.0001) in MPNs compared to controls. Conclusion: Patients with MPNs have a significantly higher prevalence of a CACS >400 and AVC, compared to controls from the general population. The association between MPN and a CACS>400 or AVC remains significant after adjustment for cardiovascular risk factors. These novel data support the hypothesis that MPNs have an increased burden of cardiac calcifications, independent of other cardiovascular risk factors.

AB - Background: Patients with the hematological cancers Philadelphia-negative Myeloproliferative Neoplasms (MPNs) have an increased risk of cardiovascular disease. However, whether MPNs have an increased burden of cardiac calcification has not been thoroughly investigated. Our aim is to investigate whether patients with MPNs have an increased burden of cardiac calcification that could help explain their increased risk of cardiovascular disease. Methods and results: We recruited 161 patients (mean age 65 years, 52% men) with an MPN diagnosis between 2016 and 2018. Coronary artery calcium score (CACS) and aortic valve calcification (AVC) were measured by cardiac computer tomography, and detailed information on cardiovascular risk factors was recorded. MPNs were matched on age and sex, with 805 controls from the Copenhagen General Population Study. A CACS>400 was present in 26% of MPNs and 19% of controls (p = 0.031). AVC was present in 58% of MPNs and 34% of controls (p < 0.0001). After adjustment for cardiovascular risk factors, the odds ratio (OR) of a CACS>400 was 1.9 (95% CI 1.2–3.1, p = 0.008) in MPNs compared to controls, and the OR of AVC was 4.4 (95% CI 2.9–6.9, p < 0.0001) in MPNs compared to controls. Conclusion: Patients with MPNs have a significantly higher prevalence of a CACS >400 and AVC, compared to controls from the general population. The association between MPN and a CACS>400 or AVC remains significant after adjustment for cardiovascular risk factors. These novel data support the hypothesis that MPNs have an increased burden of cardiac calcifications, independent of other cardiovascular risk factors.

KW - Aortic valve disease

KW - Atherosclerosis

KW - Cardiovascular diseases

KW - Coronary artery disease

KW - Multidetector computed tomography

KW - Myeloproliferative disorders

U2 - 10.1016/j.ijcard.2022.06.029

DO - 10.1016/j.ijcard.2022.06.029

M3 - Journal article

C2 - 35716942

AN - SCOPUS:85132902397

VL - 364

SP - 112

EP - 118

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -

ID: 321558157