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Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. / Byun, Jinyoung; Han, Younghun; Li, Yafang; Xia, Jun; Long, Erping; Choi, Jiyeon; Xiao, Xiangjun; Zhu, Meng; Zhou, Wen; Sun, Ryan; Bossé, Yohan; Song, Zhuoyi; Schwartz, Ann; Lusk, Christine; Rafnar, Thorunn; Stefansson, Kari; Zhang, Tongwu; Zhao, Wei; Pettit, Rowland W.; Liu, Yanhong; Li, Xihao; Zhou, Hufeng; Walsh, Kyle M.; Gorlov, Ivan; Gorlova, Olga; Zhu, Dakai; Rosenberg, Susan M.; Pinney, Susan; Bailey-Wilson, Joan E.; Mandal, Diptasri; de Andrade, Mariza; Gaba, Colette; Willey, James C.; You, Ming; Anderson, Marshall; Wiencke, John K.; Albanes, Demetrius; Lam, Stephan; Tardon, Adonina; Chen, Chu; Goodman, Gary; Bojeson, Stig; Brenner, Hermann; Landi, Maria Teresa; Chanock, Stephen J.; Johansson, Mattias; Muley, Thomas; Risch, Angela; Wichmann, H. Erich; Bickeböller, Heike; Christiani, David C.; Rennert, Gad; Arnold, Susanne; Field, John K.; Shete, Sanjay; Le Marchand, Loic; Melander, Olle; Brunnstrom, Hans; Liu, Geoffrey; Andrew, Angeline S.; Kiemeney, Lambertus A.; Shen, Hongbing; Zienolddiny, Shanbeh; Grankvist, Kjell; Johansson, Mikael; Caporaso, Neil; Cox, Angela; Hong, Yun Chul; Yuan, Jian Min; Lazarus, Philip; Schabath, Matthew B.; Aldrich, Melinda C.; Patel, Alpa; Lan, Qing; Rothman, Nathaniel; Taylor, Fiona; Kachuri, Linda; Witte, John S.; Sakoda, Lori C.; Spitz, Margaret; Brennan, Paul; Lin, Xihong; McKay, James; Hung, Rayjean J.; Amos, Christopher I.
I:
Nature Genetics, Bind 54, Nr. 8, 2022, s. 1167-1177.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Byun, J, Han, Y, Li, Y, Xia, J, Long, E, Choi, J, Xiao, X, Zhu, M, Zhou, W, Sun, R, Bossé, Y, Song, Z, Schwartz, A, Lusk, C, Rafnar, T, Stefansson, K, Zhang, T, Zhao, W, Pettit, RW, Liu, Y, Li, X, Zhou, H, Walsh, KM, Gorlov, I, Gorlova, O, Zhu, D, Rosenberg, SM, Pinney, S, Bailey-Wilson, JE, Mandal, D, de Andrade, M, Gaba, C, Willey, JC, You, M, Anderson, M, Wiencke, JK, Albanes, D, Lam, S, Tardon, A, Chen, C, Goodman, G
, Bojeson, S, Brenner, H, Landi, MT, Chanock, SJ, Johansson, M, Muley, T, Risch, A, Wichmann, HE, Bickeböller, H, Christiani, DC, Rennert, G, Arnold, S, Field, JK, Shete, S, Le Marchand, L, Melander, O, Brunnstrom, H, Liu, G, Andrew, AS, Kiemeney, LA, Shen, H, Zienolddiny, S, Grankvist, K, Johansson, M, Caporaso, N, Cox, A, Hong, YC, Yuan, JM, Lazarus, P, Schabath, MB, Aldrich, MC, Patel, A, Lan, Q, Rothman, N, Taylor, F, Kachuri, L, Witte, JS, Sakoda, LC, Spitz, M, Brennan, P, Lin, X, McKay, J, Hung, RJ & Amos, CI 2022, '
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer',
Nature Genetics, bind 54, nr. 8, s. 1167-1177.
https://doi.org/10.1038/s41588-022-01115-xAPA
Byun, J., Han, Y., Li, Y., Xia, J., Long, E., Choi, J., Xiao, X., Zhu, M., Zhou, W., Sun, R., Bossé, Y., Song, Z., Schwartz, A., Lusk, C., Rafnar, T., Stefansson, K., Zhang, T., Zhao, W., Pettit, R. W., ... Amos, C. I. (2022).
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.
Nature Genetics,
54(8), 1167-1177.
https://doi.org/10.1038/s41588-022-01115-xVancouver
Byun J, Han Y, Li Y, Xia J, Long E, Choi J o.a.
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.
Nature Genetics. 2022;54(8):1167-1177.
https://doi.org/10.1038/s41588-022-01115-xAuthor
Byun, Jinyoung ; Han, Younghun ; Li, Yafang ; Xia, Jun ; Long, Erping ; Choi, Jiyeon ; Xiao, Xiangjun ; Zhu, Meng ; Zhou, Wen ; Sun, Ryan ; Bossé, Yohan ; Song, Zhuoyi ; Schwartz, Ann ; Lusk, Christine ; Rafnar, Thorunn ; Stefansson, Kari ; Zhang, Tongwu ; Zhao, Wei ; Pettit, Rowland W. ; Liu, Yanhong ; Li, Xihao ; Zhou, Hufeng ; Walsh, Kyle M. ; Gorlov, Ivan ; Gorlova, Olga ; Zhu, Dakai ; Rosenberg, Susan M. ; Pinney, Susan ; Bailey-Wilson, Joan E. ; Mandal, Diptasri ; de Andrade, Mariza ; Gaba, Colette ; Willey, James C. ; You, Ming ; Anderson, Marshall ; Wiencke, John K. ; Albanes, Demetrius ; Lam, Stephan ; Tardon, Adonina ; Chen, Chu ; Goodman, Gary ; Bojeson, Stig ; Brenner, Hermann ; Landi, Maria Teresa ; Chanock, Stephen J. ; Johansson, Mattias ; Muley, Thomas ; Risch, Angela ; Wichmann, H. Erich ; Bickeböller, Heike ; Christiani, David C. ; Rennert, Gad ; Arnold, Susanne ; Field, John K. ; Shete, Sanjay ; Le Marchand, Loic ; Melander, Olle ; Brunnstrom, Hans ; Liu, Geoffrey ; Andrew, Angeline S. ; Kiemeney, Lambertus A. ; Shen, Hongbing ; Zienolddiny, Shanbeh ; Grankvist, Kjell ; Johansson, Mikael ; Caporaso, Neil ; Cox, Angela ; Hong, Yun Chul ; Yuan, Jian Min ; Lazarus, Philip ; Schabath, Matthew B. ; Aldrich, Melinda C. ; Patel, Alpa ; Lan, Qing ; Rothman, Nathaniel ; Taylor, Fiona ; Kachuri, Linda ; Witte, John S. ; Sakoda, Lori C. ; Spitz, Margaret ; Brennan, Paul ; Lin, Xihong ; McKay, James ; Hung, Rayjean J. ; Amos, Christopher I. / Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. I: Nature Genetics. 2022 ; Bind 54, Nr. 8. s. 1167-1177.
Bibtex
@article{84eba12b907949c7978561451a6eeda3,
title = "Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer",
abstract = "To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to populations, but even common-variant associations influencing smoking behavior, such as those with CHRNA5 and CYP2A6, showed population specificity. Fine-mapping and expression quantitative trait locus colocalization nominated several candidate variants and susceptibility genes such as IRF4 and FUBP1. DNA damage assays of prioritized genes in lung fibroblasts indicated that a subset of these genes, including the pleiotropic gene IRF4, potentially exert effects by promoting endogenous DNA damage.",
author = "Jinyoung Byun and Younghun Han and Yafang Li and Jun Xia and Erping Long and Jiyeon Choi and Xiangjun Xiao and Meng Zhu and Wen Zhou and Ryan Sun and Yohan Boss{\'e} and Zhuoyi Song and Ann Schwartz and Christine Lusk and Thorunn Rafnar and Kari Stefansson and Tongwu Zhang and Wei Zhao and Pettit, {Rowland W.} and Yanhong Liu and Xihao Li and Hufeng Zhou and Walsh, {Kyle M.} and Ivan Gorlov and Olga Gorlova and Dakai Zhu and Rosenberg, {Susan M.} and Susan Pinney and Bailey-Wilson, {Joan E.} and Diptasri Mandal and {de Andrade}, Mariza and Colette Gaba and Willey, {James C.} and Ming You and Marshall Anderson and Wiencke, {John K.} and Demetrius Albanes and Stephan Lam and Adonina Tardon and Chu Chen and Gary Goodman and Stig Bojeson and Hermann Brenner and Landi, {Maria Teresa} and Chanock, {Stephen J.} and Mattias Johansson and Thomas Muley and Angela Risch and Wichmann, {H. Erich} and Heike Bickeb{\"o}ller and Christiani, {David C.} and Gad Rennert and Susanne Arnold and Field, {John K.} and Sanjay Shete and {Le Marchand}, Loic and Olle Melander and Hans Brunnstrom and Geoffrey Liu and Andrew, {Angeline S.} and Kiemeney, {Lambertus A.} and Hongbing Shen and Shanbeh Zienolddiny and Kjell Grankvist and Mikael Johansson and Neil Caporaso and Angela Cox and Hong, {Yun Chul} and Yuan, {Jian Min} and Philip Lazarus and Schabath, {Matthew B.} and Aldrich, {Melinda C.} and Alpa Patel and Qing Lan and Nathaniel Rothman and Fiona Taylor and Linda Kachuri and Witte, {John S.} and Sakoda, {Lori C.} and Margaret Spitz and Paul Brennan and Xihong Lin and James McKay and Hung, {Rayjean J.} and Amos, {Christopher I.}",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2022",
doi = "10.1038/s41588-022-01115-x",
language = "English",
volume = "54",
pages = "1167--1177",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "8",
}
RIS
TY - JOUR
T1 - Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer
AU - Byun, Jinyoung
AU - Han, Younghun
AU - Li, Yafang
AU - Xia, Jun
AU - Long, Erping
AU - Choi, Jiyeon
AU - Xiao, Xiangjun
AU - Zhu, Meng
AU - Zhou, Wen
AU - Sun, Ryan
AU - Bossé, Yohan
AU - Song, Zhuoyi
AU - Schwartz, Ann
AU - Lusk, Christine
AU - Rafnar, Thorunn
AU - Stefansson, Kari
AU - Zhang, Tongwu
AU - Zhao, Wei
AU - Pettit, Rowland W.
AU - Liu, Yanhong
AU - Li, Xihao
AU - Zhou, Hufeng
AU - Walsh, Kyle M.
AU - Gorlov, Ivan
AU - Gorlova, Olga
AU - Zhu, Dakai
AU - Rosenberg, Susan M.
AU - Pinney, Susan
AU - Bailey-Wilson, Joan E.
AU - Mandal, Diptasri
AU - de Andrade, Mariza
AU - Gaba, Colette
AU - Willey, James C.
AU - You, Ming
AU - Anderson, Marshall
AU - Wiencke, John K.
AU - Albanes, Demetrius
AU - Lam, Stephan
AU - Tardon, Adonina
AU - Chen, Chu
AU - Goodman, Gary
AU - Bojeson, Stig
AU - Brenner, Hermann
AU - Landi, Maria Teresa
AU - Chanock, Stephen J.
AU - Johansson, Mattias
AU - Muley, Thomas
AU - Risch, Angela
AU - Wichmann, H. Erich
AU - Bickeböller, Heike
AU - Christiani, David C.
AU - Rennert, Gad
AU - Arnold, Susanne
AU - Field, John K.
AU - Shete, Sanjay
AU - Le Marchand, Loic
AU - Melander, Olle
AU - Brunnstrom, Hans
AU - Liu, Geoffrey
AU - Andrew, Angeline S.
AU - Kiemeney, Lambertus A.
AU - Shen, Hongbing
AU - Zienolddiny, Shanbeh
AU - Grankvist, Kjell
AU - Johansson, Mikael
AU - Caporaso, Neil
AU - Cox, Angela
AU - Hong, Yun Chul
AU - Yuan, Jian Min
AU - Lazarus, Philip
AU - Schabath, Matthew B.
AU - Aldrich, Melinda C.
AU - Patel, Alpa
AU - Lan, Qing
AU - Rothman, Nathaniel
AU - Taylor, Fiona
AU - Kachuri, Linda
AU - Witte, John S.
AU - Sakoda, Lori C.
AU - Spitz, Margaret
AU - Brennan, Paul
AU - Lin, Xihong
AU - McKay, James
AU - Hung, Rayjean J.
AU - Amos, Christopher I.
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022
Y1 - 2022
N2 - To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to populations, but even common-variant associations influencing smoking behavior, such as those with CHRNA5 and CYP2A6, showed population specificity. Fine-mapping and expression quantitative trait locus colocalization nominated several candidate variants and susceptibility genes such as IRF4 and FUBP1. DNA damage assays of prioritized genes in lung fibroblasts indicated that a subset of these genes, including the pleiotropic gene IRF4, potentially exert effects by promoting endogenous DNA damage.
AB - To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to populations, but even common-variant associations influencing smoking behavior, such as those with CHRNA5 and CYP2A6, showed population specificity. Fine-mapping and expression quantitative trait locus colocalization nominated several candidate variants and susceptibility genes such as IRF4 and FUBP1. DNA damage assays of prioritized genes in lung fibroblasts indicated that a subset of these genes, including the pleiotropic gene IRF4, potentially exert effects by promoting endogenous DNA damage.
U2 - 10.1038/s41588-022-01115-x
DO - 10.1038/s41588-022-01115-x
M3 - Journal article
C2 - 35915169
AN - SCOPUS:85135272569
VL - 54
SP - 1167
EP - 1177
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 8
ER -
