Early Coronary Atherosclerosis in Women With Previous Preeclampsia

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Standard

Early Coronary Atherosclerosis in Women With Previous Preeclampsia. / Hauge, Maria G.; Damm, Peter; Kofoed, Klaus F.; Ersbøll, Anne S.; Johansen, Marianne; Sigvardsen, Per E.; Møller, Mathias B.; Fuchs, Andreas; Kühl, Jørgen T.; Nordestgaard, Børge G.; Køber, Lars V.; Gustafsson, Finn; Linde, Jesper J.

I: Journal of the American College of Cardiology, Bind 79, Nr. 23, 2022, s. 2310-2321.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hauge, MG, Damm, P, Kofoed, KF, Ersbøll, AS, Johansen, M, Sigvardsen, PE, Møller, MB, Fuchs, A, Kühl, JT, Nordestgaard, BG, Køber, LV, Gustafsson, F & Linde, JJ 2022, 'Early Coronary Atherosclerosis in Women With Previous Preeclampsia', Journal of the American College of Cardiology, bind 79, nr. 23, s. 2310-2321. https://doi.org/10.1016/j.jacc.2022.03.381

APA

Hauge, M. G., Damm, P., Kofoed, K. F., Ersbøll, A. S., Johansen, M., Sigvardsen, P. E., Møller, M. B., Fuchs, A., Kühl, J. T., Nordestgaard, B. G., Køber, L. V., Gustafsson, F., & Linde, J. J. (2022). Early Coronary Atherosclerosis in Women With Previous Preeclampsia. Journal of the American College of Cardiology, 79(23), 2310-2321. https://doi.org/10.1016/j.jacc.2022.03.381

Vancouver

Hauge MG, Damm P, Kofoed KF, Ersbøll AS, Johansen M, Sigvardsen PE o.a. Early Coronary Atherosclerosis in Women With Previous Preeclampsia. Journal of the American College of Cardiology. 2022;79(23):2310-2321. https://doi.org/10.1016/j.jacc.2022.03.381

Author

Hauge, Maria G. ; Damm, Peter ; Kofoed, Klaus F. ; Ersbøll, Anne S. ; Johansen, Marianne ; Sigvardsen, Per E. ; Møller, Mathias B. ; Fuchs, Andreas ; Kühl, Jørgen T. ; Nordestgaard, Børge G. ; Køber, Lars V. ; Gustafsson, Finn ; Linde, Jesper J. / Early Coronary Atherosclerosis in Women With Previous Preeclampsia. I: Journal of the American College of Cardiology. 2022 ; Bind 79, Nr. 23. s. 2310-2321.

Bibtex

@article{9f9a6ba4b991452192eee420afdc28a7,
title = "Early Coronary Atherosclerosis in Women With Previous Preeclampsia",
abstract = "Background: Women with previous preeclampsia have an increased risk of coronary artery disease later in life. Objectives: This study aimed to determine the prevalence of coronary atherosclerosis in younger women with previous preeclampsia in comparison with women from the general population. Methods: Women aged 40-55 years with previous preeclampsia were matched 1:1 on age and parity with women from the general population. Participants completed an extensive questionnaire, a clinical examination, and a coronary computed tomography angiography (CTA). The main study outcome was the prevalence of any coronary atherosclerosis on coronary CTA or a calcium score >0 in case of a nondiagnostic coronary CTA. Results: A total of 1,417 women, with a mean age of 47 years, were included (708 women with previous preeclampsia and 709 control subjects from the general population). Women with previous preeclampsia were more likely to have hypertension (284 [40.1%] vs 162 [22.8%]; P < 0.001), dyslipidemia (338 [47.7%] vs 296 [41.7%]; P = 0.023), diabetes mellitus (24 [3.4%] vs 8 [1.1%]; P = 0.004), and high body mass index (27.3 ± 5.7 kg/m2 vs 25.0 ± 4.2 kg/m2; P < 0.001). Cardiac computed tomography was performed in all women. The prevalence of any coronary atherosclerosis was higher in the preeclampsia group (193 [27.4%] vs 141 [20.0%]; P = 0.001) with an OR: 1.41 (95% CI: 1.08-1.85; P = 0.012) after adjustment for age, dyslipidemia, diabetes mellitus, smoking, body mass index, menopause, and parity. Conclusions: Younger women with previous preeclampsia had a slightly higher prevalence of coronary atherosclerosis compared with age- and parity-matched women from the general population. Preeclampsia remained an independent risk factor after adjustment for traditional cardiovascular risk factors. (The CoPenHagen PREeClampsia and cardIOvascUlar diSease study [CPH-PRECIOUS]; NCT03949829)",
keywords = "angiography, atherosclerosis, cardiac CT, cardiovascular disease, preeclampsia, women",
author = "Hauge, {Maria G.} and Peter Damm and Kofoed, {Klaus F.} and Ersb{\o}ll, {Anne S.} and Marianne Johansen and Sigvardsen, {Per E.} and M{\o}ller, {Mathias B.} and Andreas Fuchs and K{\"u}hl, {J{\o}rgen T.} and Nordestgaard, {B{\o}rge G.} and K{\o}ber, {Lars V.} and Finn Gustafsson and Linde, {Jesper J.}",
note = "Publisher Copyright: {\textcopyright} 2022 American College of Cardiology Foundation",
year = "2022",
doi = "10.1016/j.jacc.2022.03.381",
language = "English",
volume = "79",
pages = "2310--2321",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier",
number = "23",

}

RIS

TY - JOUR

T1 - Early Coronary Atherosclerosis in Women With Previous Preeclampsia

AU - Hauge, Maria G.

AU - Damm, Peter

AU - Kofoed, Klaus F.

AU - Ersbøll, Anne S.

AU - Johansen, Marianne

AU - Sigvardsen, Per E.

AU - Møller, Mathias B.

AU - Fuchs, Andreas

AU - Kühl, Jørgen T.

AU - Nordestgaard, Børge G.

AU - Køber, Lars V.

AU - Gustafsson, Finn

AU - Linde, Jesper J.

N1 - Publisher Copyright: © 2022 American College of Cardiology Foundation

PY - 2022

Y1 - 2022

N2 - Background: Women with previous preeclampsia have an increased risk of coronary artery disease later in life. Objectives: This study aimed to determine the prevalence of coronary atherosclerosis in younger women with previous preeclampsia in comparison with women from the general population. Methods: Women aged 40-55 years with previous preeclampsia were matched 1:1 on age and parity with women from the general population. Participants completed an extensive questionnaire, a clinical examination, and a coronary computed tomography angiography (CTA). The main study outcome was the prevalence of any coronary atherosclerosis on coronary CTA or a calcium score >0 in case of a nondiagnostic coronary CTA. Results: A total of 1,417 women, with a mean age of 47 years, were included (708 women with previous preeclampsia and 709 control subjects from the general population). Women with previous preeclampsia were more likely to have hypertension (284 [40.1%] vs 162 [22.8%]; P < 0.001), dyslipidemia (338 [47.7%] vs 296 [41.7%]; P = 0.023), diabetes mellitus (24 [3.4%] vs 8 [1.1%]; P = 0.004), and high body mass index (27.3 ± 5.7 kg/m2 vs 25.0 ± 4.2 kg/m2; P < 0.001). Cardiac computed tomography was performed in all women. The prevalence of any coronary atherosclerosis was higher in the preeclampsia group (193 [27.4%] vs 141 [20.0%]; P = 0.001) with an OR: 1.41 (95% CI: 1.08-1.85; P = 0.012) after adjustment for age, dyslipidemia, diabetes mellitus, smoking, body mass index, menopause, and parity. Conclusions: Younger women with previous preeclampsia had a slightly higher prevalence of coronary atherosclerosis compared with age- and parity-matched women from the general population. Preeclampsia remained an independent risk factor after adjustment for traditional cardiovascular risk factors. (The CoPenHagen PREeClampsia and cardIOvascUlar diSease study [CPH-PRECIOUS]; NCT03949829)

AB - Background: Women with previous preeclampsia have an increased risk of coronary artery disease later in life. Objectives: This study aimed to determine the prevalence of coronary atherosclerosis in younger women with previous preeclampsia in comparison with women from the general population. Methods: Women aged 40-55 years with previous preeclampsia were matched 1:1 on age and parity with women from the general population. Participants completed an extensive questionnaire, a clinical examination, and a coronary computed tomography angiography (CTA). The main study outcome was the prevalence of any coronary atherosclerosis on coronary CTA or a calcium score >0 in case of a nondiagnostic coronary CTA. Results: A total of 1,417 women, with a mean age of 47 years, were included (708 women with previous preeclampsia and 709 control subjects from the general population). Women with previous preeclampsia were more likely to have hypertension (284 [40.1%] vs 162 [22.8%]; P < 0.001), dyslipidemia (338 [47.7%] vs 296 [41.7%]; P = 0.023), diabetes mellitus (24 [3.4%] vs 8 [1.1%]; P = 0.004), and high body mass index (27.3 ± 5.7 kg/m2 vs 25.0 ± 4.2 kg/m2; P < 0.001). Cardiac computed tomography was performed in all women. The prevalence of any coronary atherosclerosis was higher in the preeclampsia group (193 [27.4%] vs 141 [20.0%]; P = 0.001) with an OR: 1.41 (95% CI: 1.08-1.85; P = 0.012) after adjustment for age, dyslipidemia, diabetes mellitus, smoking, body mass index, menopause, and parity. Conclusions: Younger women with previous preeclampsia had a slightly higher prevalence of coronary atherosclerosis compared with age- and parity-matched women from the general population. Preeclampsia remained an independent risk factor after adjustment for traditional cardiovascular risk factors. (The CoPenHagen PREeClampsia and cardIOvascUlar diSease study [CPH-PRECIOUS]; NCT03949829)

KW - angiography

KW - atherosclerosis

KW - cardiac CT

KW - cardiovascular disease

KW - preeclampsia

KW - women

U2 - 10.1016/j.jacc.2022.03.381

DO - 10.1016/j.jacc.2022.03.381

M3 - Journal article

C2 - 35680182

AN - SCOPUS:85130771893

VL - 79

SP - 2310

EP - 2321

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 23

ER -

ID: 310436337