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Gene-environment interactions relevant to estrogen and risk of breast cancer : Can gene-environment interactions be detected only among candidate snps from genome-wide association studies? / Park, Joo Yong; Choi, Ji Yeob; Choi, Jaesung; Chung, Seokang; Song, Nan; Park, Sue K.; Han, Wonshik; Noh, Dong Young; Ahn, Sei Hyun; Lee, Jong Won; Kim, Mi Kyung; Jee, Sun Ha; Wen, Wanqing; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Michailidou, Kyriaki; Shah, Mitul; Conroy, Don M.; Harrington, Patricia A.; Mayes, Rebecca; Czene, Kamila; Hall, Per; Teras, Lauren R.; Patel, Alpa V.; Couch, Fergus J.; Olson, Janet E.; Sawyer, Elinor J.; Roylance, Rebecca; Bojesen, Stig E.; Flyger, Henrik; Lambrechts, Diether; Baten, Adinda; Matsuo, Keitaro; Ito, Hidemi; Guénel, Pascal; Truong, Thérèse; Keeman, Renske; Schmidt, Marjanka K.; Wu, Anna H.; Tseng, Chiu Chen; Cox, Angela; Cross, Simon S.; Investigators, Kconfab; Andrulis, Irene L.; Hopper, John L.; Southey, Melissa C.; Wu, Pei Ei; Shen, Chen Yang; Fasching, Peter A.; Ekici, Arif B.; Muir, Kenneth; Lophatananon, Artitaya; Brenner, Hermann; Arndt, Volker; Jones, Michael E.; Swerdlow, Anthony J.; Hoppe, Reiner; Ko, Yon Dschun; Hartman, Mikael; Li, Jingmei; Mannermaa, Arto; Hartikainen, Jaana M.; Benitez, Javier; González-Neira, Anna; Haiman, Christopher A.; Dörk, Thilo; Bogdanova, Natalia V.; Teo, Soo Hwang; Taib, Nur Aishah Mohd; Fletcher, Olivia; Johnson, Nichola; Grip, Mervi; Winqvist, Robert; Blomqvist, Carl; Nevanlinna, Heli; Lindblom, Annika; Wendt, Camilla; Kristensen, Vessela N.; Collaborators, N. B.C.S.; Tollenaar, Rob A.E.M.; Heemskerk-Gerritsen, Bernadette A.M.; Radice, Paolo; Bonanni, Bernardo; Hamann, Ute; Manoochehri, Mehdi; Lacey, James V.; Martinez, Maria Elena; Dunning, Alison M.; Pharoah, Paul D.P.; Easton, Douglas F.; Yoo, Keun Young; Kang, Daehee.
I:
Cancers, Bind 13, Nr. 10, 2370, 2021.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Park, JY, Choi, JY, Choi, J, Chung, S, Song, N, Park, SK, Han, W, Noh, DY, Ahn, SH, Lee, JW, Kim, MK, Jee, SH, Wen, W, Bolla, MK, Wang, Q, Dennis, J, Michailidou, K, Shah, M, Conroy, DM, Harrington, PA, Mayes, R, Czene, K, Hall, P, Teras, LR, Patel, AV, Couch, FJ, Olson, JE, Sawyer, EJ, Roylance, R
, Bojesen, SE, Flyger, H, Lambrechts, D, Baten, A, Matsuo, K, Ito, H, Guénel, P, Truong, T, Keeman, R, Schmidt, MK, Wu, AH, Tseng, CC, Cox, A, Cross, SS, Investigators, K, Andrulis, IL, Hopper, JL, Southey, MC, Wu, PE, Shen, CY, Fasching, PA, Ekici, AB, Muir, K, Lophatananon, A, Brenner, H, Arndt, V, Jones, ME, Swerdlow, AJ, Hoppe, R, Ko, YD, Hartman, M, Li, J, Mannermaa, A, Hartikainen, JM, Benitez, J, González-Neira, A, Haiman, CA, Dörk, T, Bogdanova, NV, Teo, SH, Taib, NAM, Fletcher, O, Johnson, N, Grip, M, Winqvist, R, Blomqvist, C, Nevanlinna, H, Lindblom, A, Wendt, C, Kristensen, VN, Collaborators, NBCS, Tollenaar, RAEM, Heemskerk-Gerritsen, BAM, Radice, P, Bonanni, B, Hamann, U, Manoochehri, M, Lacey, JV, Martinez, ME, Dunning, AM, Pharoah, PDP, Easton, DF, Yoo, KY & Kang, D 2021, '
Gene-environment interactions relevant to estrogen and risk of breast cancer: Can gene-environment interactions be detected only among candidate snps from genome-wide association studies?',
Cancers, bind 13, nr. 10, 2370.
https://doi.org/10.3390/cancers13102370APA
Park, J. Y., Choi, J. Y., Choi, J., Chung, S., Song, N., Park, S. K., Han, W., Noh, D. Y., Ahn, S. H., Lee, J. W., Kim, M. K., Jee, S. H., Wen, W., Bolla, M. K., Wang, Q., Dennis, J., Michailidou, K., Shah, M., Conroy, D. M., ... Kang, D. (2021).
Gene-environment interactions relevant to estrogen and risk of breast cancer: Can gene-environment interactions be detected only among candidate snps from genome-wide association studies? Cancers,
13(10), [2370].
https://doi.org/10.3390/cancers13102370Vancouver
Park JY, Choi JY, Choi J, Chung S, Song N, Park SK o.a.
Gene-environment interactions relevant to estrogen and risk of breast cancer: Can gene-environment interactions be detected only among candidate snps from genome-wide association studies? Cancers. 2021;13(10). 2370.
https://doi.org/10.3390/cancers13102370Author
Park, Joo Yong ; Choi, Ji Yeob ; Choi, Jaesung ; Chung, Seokang ; Song, Nan ; Park, Sue K. ; Han, Wonshik ; Noh, Dong Young ; Ahn, Sei Hyun ; Lee, Jong Won ; Kim, Mi Kyung ; Jee, Sun Ha ; Wen, Wanqing ; Bolla, Manjeet K. ; Wang, Qin ; Dennis, Joe ; Michailidou, Kyriaki ; Shah, Mitul ; Conroy, Don M. ; Harrington, Patricia A. ; Mayes, Rebecca ; Czene, Kamila ; Hall, Per ; Teras, Lauren R. ; Patel, Alpa V. ; Couch, Fergus J. ; Olson, Janet E. ; Sawyer, Elinor J. ; Roylance, Rebecca ; Bojesen, Stig E. ; Flyger, Henrik ; Lambrechts, Diether ; Baten, Adinda ; Matsuo, Keitaro ; Ito, Hidemi ; Guénel, Pascal ; Truong, Thérèse ; Keeman, Renske ; Schmidt, Marjanka K. ; Wu, Anna H. ; Tseng, Chiu Chen ; Cox, Angela ; Cross, Simon S. ; Investigators, Kconfab ; Andrulis, Irene L. ; Hopper, John L. ; Southey, Melissa C. ; Wu, Pei Ei ; Shen, Chen Yang ; Fasching, Peter A. ; Ekici, Arif B. ; Muir, Kenneth ; Lophatananon, Artitaya ; Brenner, Hermann ; Arndt, Volker ; Jones, Michael E. ; Swerdlow, Anthony J. ; Hoppe, Reiner ; Ko, Yon Dschun ; Hartman, Mikael ; Li, Jingmei ; Mannermaa, Arto ; Hartikainen, Jaana M. ; Benitez, Javier ; González-Neira, Anna ; Haiman, Christopher A. ; Dörk, Thilo ; Bogdanova, Natalia V. ; Teo, Soo Hwang ; Taib, Nur Aishah Mohd ; Fletcher, Olivia ; Johnson, Nichola ; Grip, Mervi ; Winqvist, Robert ; Blomqvist, Carl ; Nevanlinna, Heli ; Lindblom, Annika ; Wendt, Camilla ; Kristensen, Vessela N. ; Collaborators, N. B.C.S. ; Tollenaar, Rob A.E.M. ; Heemskerk-Gerritsen, Bernadette A.M. ; Radice, Paolo ; Bonanni, Bernardo ; Hamann, Ute ; Manoochehri, Mehdi ; Lacey, James V. ; Martinez, Maria Elena ; Dunning, Alison M. ; Pharoah, Paul D.P. ; Easton, Douglas F. ; Yoo, Keun Young ; Kang, Daehee. / Gene-environment interactions relevant to estrogen and risk of breast cancer : Can gene-environment interactions be detected only among candidate snps from genome-wide association studies?. I: Cancers. 2021 ; Bind 13, Nr. 10.
Bibtex
@article{7a21788fdde94a6789b7a7aabc275f52,
title = "Gene-environment interactions relevant to estrogen and risk of breast cancer: Can gene-environment interactions be detected only among candidate snps from genome-wide association studies?",
abstract = "In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 × 10−3 ). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 × 10−4 ). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.",
keywords = "Breast cancer, Estrogen, Gene-environment interaction",
author = "Park, {Joo Yong} and Choi, {Ji Yeob} and Jaesung Choi and Seokang Chung and Nan Song and Park, {Sue K.} and Wonshik Han and Noh, {Dong Young} and Ahn, {Sei Hyun} and Lee, {Jong Won} and Kim, {Mi Kyung} and Jee, {Sun Ha} and Wanqing Wen and Bolla, {Manjeet K.} and Qin Wang and Joe Dennis and Kyriaki Michailidou and Mitul Shah and Conroy, {Don M.} and Harrington, {Patricia A.} and Rebecca Mayes and Kamila Czene and Per Hall and Teras, {Lauren R.} and Patel, {Alpa V.} and Couch, {Fergus J.} and Olson, {Janet E.} and Sawyer, {Elinor J.} and Rebecca Roylance and Bojesen, {Stig E.} and Henrik Flyger and Diether Lambrechts and Adinda Baten and Keitaro Matsuo and Hidemi Ito and Pascal Gu{\'e}nel and Th{\'e}r{\`e}se Truong and Renske Keeman and Schmidt, {Marjanka K.} and Wu, {Anna H.} and Tseng, {Chiu Chen} and Angela Cox and Cross, {Simon S.} and Kconfab Investigators and Andrulis, {Irene L.} and Hopper, {John L.} and Southey, {Melissa C.} and Wu, {Pei Ei} and Shen, {Chen Yang} and Fasching, {Peter A.} and Ekici, {Arif B.} and Kenneth Muir and Artitaya Lophatananon and Hermann Brenner and Volker Arndt and Jones, {Michael E.} and Swerdlow, {Anthony J.} and Reiner Hoppe and Ko, {Yon Dschun} and Mikael Hartman and Jingmei Li and Arto Mannermaa and Hartikainen, {Jaana M.} and Javier Benitez and Anna Gonz{\'a}lez-Neira and Haiman, {Christopher A.} and Thilo D{\"o}rk and Bogdanova, {Natalia V.} and Teo, {Soo Hwang} and Taib, {Nur Aishah Mohd} and Olivia Fletcher and Nichola Johnson and Mervi Grip and Robert Winqvist and Carl Blomqvist and Heli Nevanlinna and Annika Lindblom and Camilla Wendt and Kristensen, {Vessela N.} and Collaborators, {N. B.C.S.} and Tollenaar, {Rob A.E.M.} and Heemskerk-Gerritsen, {Bernadette A.M.} and Paolo Radice and Bernardo Bonanni and Ute Hamann and Mehdi Manoochehri and Lacey, {James V.} and Martinez, {Maria Elena} and Dunning, {Alison M.} and Pharoah, {Paul D.P.} and Easton, {Douglas F.} and Yoo, {Keun Young} and Daehee Kang",
note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
doi = "10.3390/cancers13102370",
language = "English",
volume = "13",
journal = "Cancers",
issn = "2072-6694",
publisher = "M D P I AG",
number = "10",
}
RIS
TY - JOUR
T1 - Gene-environment interactions relevant to estrogen and risk of breast cancer
T2 - Can gene-environment interactions be detected only among candidate snps from genome-wide association studies?
AU - Park, Joo Yong
AU - Choi, Ji Yeob
AU - Choi, Jaesung
AU - Chung, Seokang
AU - Song, Nan
AU - Park, Sue K.
AU - Han, Wonshik
AU - Noh, Dong Young
AU - Ahn, Sei Hyun
AU - Lee, Jong Won
AU - Kim, Mi Kyung
AU - Jee, Sun Ha
AU - Wen, Wanqing
AU - Bolla, Manjeet K.
AU - Wang, Qin
AU - Dennis, Joe
AU - Michailidou, Kyriaki
AU - Shah, Mitul
AU - Conroy, Don M.
AU - Harrington, Patricia A.
AU - Mayes, Rebecca
AU - Czene, Kamila
AU - Hall, Per
AU - Teras, Lauren R.
AU - Patel, Alpa V.
AU - Couch, Fergus J.
AU - Olson, Janet E.
AU - Sawyer, Elinor J.
AU - Roylance, Rebecca
AU - Bojesen, Stig E.
AU - Flyger, Henrik
AU - Lambrechts, Diether
AU - Baten, Adinda
AU - Matsuo, Keitaro
AU - Ito, Hidemi
AU - Guénel, Pascal
AU - Truong, Thérèse
AU - Keeman, Renske
AU - Schmidt, Marjanka K.
AU - Wu, Anna H.
AU - Tseng, Chiu Chen
AU - Cox, Angela
AU - Cross, Simon S.
AU - Investigators, Kconfab
AU - Andrulis, Irene L.
AU - Hopper, John L.
AU - Southey, Melissa C.
AU - Wu, Pei Ei
AU - Shen, Chen Yang
AU - Fasching, Peter A.
AU - Ekici, Arif B.
AU - Muir, Kenneth
AU - Lophatananon, Artitaya
AU - Brenner, Hermann
AU - Arndt, Volker
AU - Jones, Michael E.
AU - Swerdlow, Anthony J.
AU - Hoppe, Reiner
AU - Ko, Yon Dschun
AU - Hartman, Mikael
AU - Li, Jingmei
AU - Mannermaa, Arto
AU - Hartikainen, Jaana M.
AU - Benitez, Javier
AU - González-Neira, Anna
AU - Haiman, Christopher A.
AU - Dörk, Thilo
AU - Bogdanova, Natalia V.
AU - Teo, Soo Hwang
AU - Taib, Nur Aishah Mohd
AU - Fletcher, Olivia
AU - Johnson, Nichola
AU - Grip, Mervi
AU - Winqvist, Robert
AU - Blomqvist, Carl
AU - Nevanlinna, Heli
AU - Lindblom, Annika
AU - Wendt, Camilla
AU - Kristensen, Vessela N.
AU - Collaborators, N. B.C.S.
AU - Tollenaar, Rob A.E.M.
AU - Heemskerk-Gerritsen, Bernadette A.M.
AU - Radice, Paolo
AU - Bonanni, Bernardo
AU - Hamann, Ute
AU - Manoochehri, Mehdi
AU - Lacey, James V.
AU - Martinez, Maria Elena
AU - Dunning, Alison M.
AU - Pharoah, Paul D.P.
AU - Easton, Douglas F.
AU - Yoo, Keun Young
AU - Kang, Daehee
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 × 10−3 ). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 × 10−4 ). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.
AB - In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 × 10−3 ). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 × 10−4 ). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.
KW - Breast cancer
KW - Estrogen
KW - Gene-environment interaction
U2 - 10.3390/cancers13102370
DO - 10.3390/cancers13102370
M3 - Journal article
C2 - 34069208
AN - SCOPUS:85106038603
VL - 13
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 10
M1 - 2370
ER -
