Standard
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population. / Shi, Jianxin; Shiraishi, Kouya; Choi, Jiyeon; Matsuo, Keitaro; Chen, Tzu Yu; Dai, Juncheng; Hung, Rayjean J.; Chen, Kexin; Shu, Xiao Ou; Kim, Young Tae; Landi, Maria Teresa; Lin, Dongxin; Zheng, Wei; Yin, Zhihua; Zhou, Baosen; Song, Bao; Wang, Jiucun; Seow, Wei Jie; Song, Lei; Chang, I. Shou; Hu, Wei; Chien, Li Hsin; Cai, Qiuyin; Hong, Yun Chul; Kim, Hee Nam; Wu, Yi Long; Wong, Maria Pik; Richardson, Brian Douglas; Funderburk, Karen M.; Li, Shilan; Zhang, Tongwu; Breeze, Charles; Wang, Zhaoming; Blechter, Batel; Bassig, Bryan A.; Kim, Jin Hee; Albanes, Demetrius; Wong, Jason Y.Y.; Shin, Min Ho; Chung, Lap Ping; Yang, Yang; An, She Juan; Zheng, Hong; Yatabe, Yasushi; Zhang, Xu Chao; Kim, Young Chul; Caporaso, Neil E.; Chang, Jiang; Ho, James Chung Man; Kubo, Michiaki; Daigo, Yataro; Song, Minsun; Momozawa, Yukihide; Kamatani, Yoichiro; Kobayashi, Masashi; Okubo, Kenichi; Honda, Takayuki; Hosgood, Dean H.; Kunitoh, Hideo; Patel, Harsh; Watanabe, Shun ichi; Miyagi, Yohei; Nakayama, Haruhiko; Matsumoto, Shingo; Horinouchi, Hidehito; Tsuboi, Masahiro; Hamamoto, Ryuji; Goto, Koichi; Ohe, Yuichiro; Takahashi, Atsushi; Goto, Akiteru; Minamiya, Yoshihiro; Hara, Megumi; Nishida, Yuichiro; Takeuchi, Kenji; Wakai, Kenji; Matsuda, Koichi; Murakami, Yoshinori; Shimizu, Kimihiro; Suzuki, Hiroyuki; Saito, Motonobu; Ohtaki, Yoichi; Tanaka, Kazumi; Wu, Tangchun; Wei, Fusheng; Dai, Hongji; Machiela, Mitchell J.; Su, Jian; Kim, Yeul Hong; Oh, In Jae; Lee, Victor Ho Fun; Chang, Gee Chen; Tsai, Ying Huang; Chen, Kuan Yu; Huang, Ming Shyan; Su, Wu Chou; Chen, Yuh Min; Seow, Adeline; Park, Jae Yong; Kweon, Sun Seog; Chen, Kun Chieh; Gao, Yu Tang; Qian, Biyun; Wu, Chen; Lu, Daru; Liu, Jianjun; Schwartz, Ann G.; Houlston, Richard; Spitz, Margaret R.; Gorlov, Ivan P.; Wu, Xifeng; Yang, Ping; Lam, Stephen; Tardon, Adonina; Chen, Chu; Bojesen, Stig E.; Johansson, Mattias; Risch, Angela; Bickeböller, Heike; Ji, Bu Tian; Wichmann, H. Erich; Christiani, David C.; Rennert, Gadi; Arnold, Susanne; Brennan, Paul; McKay, James; Field, John K.; Shete, Sanjay S.; Le Marchand, Loic; Liu, Geoffrey; Andrew, Angeline; Kiemeney, Lambertus A.; Zienolddiny-Narui, Shan; Grankvist, Kjell; Johansson, Mikael; Cox, Angela; Taylor, Fiona; Yuan, Jian Min; Lazarus, Philip; Schabath, Matthew B.; Aldrich, Melinda C.; Jeon, Hyo Sung; Jiang, Shih Sheng; Sung, Jae Sook; Chen, Chung Hsing; Hsiao, Chin Fu; Jung, Yoo Jin; Guo, Huan; Hu, Zhibin; Burdett, Laurie; Yeager, Meredith; Hutchinson, Amy; Hicks, Belynda; Liu, Jia; Zhu, Bin; Berndt, Sonja I.; Wu, Wei; Wang, Junwen; Li, Yuqing; Choi, Jin Eun; Park, Kyong Hwa; Sung, Sook Whan; Liu, Li; Kang, Chang Hyun; Wang, Wen Chang; Xu, Jun; Guan, Peng; Tan, Wen; Yu, Chong Jen; Yang, Gong; Sihoe, Alan Dart Loon; Chen, Ying; Choi, Yi Young; Kim, Jun Suk; Yoon, Ho Il; Park, In Kyu; Xu, Ping; He, Qincheng; Wang, Chih Liang; Hung, Hsiao Han; Vermeulen, Roel C.H.; Cheng, Iona; Wu, Junjie; Lim, Wei Yen; Tsai, Fang Yu; Chan, John K.C.; Li, Jihua; Chen, Hongyan; Lin, Hsien Chih; Jin, Li; Liu, Jie; Sawada, Norie; Yamaji, Taiki; Wyatt, Kathleen; Li, Shengchao A.; Ma, Hongxia; Zhu, Meng; Wang, Zhehai; Cheng, Sensen; Li, Xuelian; Ren, Yangwu; Chao, Ann; Iwasaki, Motoki; Zhu, Junjie; Jiang, Gening; Fei, Ke; Wu, Guoping; Chen, Chih Yi; Chen, Chien Jen; Yang, Pan Chyr; Yu, Jinming; Stevens, Victoria L.; Fraumeni, Joseph F.; Chatterjee, Nilanjan; Gorlova, Olga Y.; Hsiung, Chao Agnes; Amos, Christopher I.; Shen, Hongbing; Chanock, Stephen J.; Rothman, Nathaniel; Kohno, Takashi; Lan, Qing.
I:
Nature Communications, Bind 14, Nr. 1, 3043, 2023.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Shi, J, Shiraishi, K, Choi, J, Matsuo, K, Chen, TY, Dai, J, Hung, RJ, Chen, K, Shu, XO, Kim, YT, Landi, MT, Lin, D, Zheng, W, Yin, Z, Zhou, B, Song, B, Wang, J, Seow, WJ, Song, L, Chang, IS, Hu, W, Chien, LH, Cai, Q, Hong, YC, Kim, HN, Wu, YL, Wong, MP, Richardson, BD, Funderburk, KM, Li, S, Zhang, T, Breeze, C, Wang, Z, Blechter, B, Bassig, BA, Kim, JH, Albanes, D, Wong, JYY, Shin, MH, Chung, LP, Yang, Y, An, SJ, Zheng, H, Yatabe, Y, Zhang, XC, Kim, YC, Caporaso, NE, Chang, J, Ho, JCM, Kubo, M, Daigo, Y, Song, M, Momozawa, Y, Kamatani, Y, Kobayashi, M, Okubo, K, Honda, T, Hosgood, DH, Kunitoh, H, Patel, H, Watanabe, SI, Miyagi, Y, Nakayama, H, Matsumoto, S, Horinouchi, H, Tsuboi, M, Hamamoto, R, Goto, K, Ohe, Y, Takahashi, A, Goto, A, Minamiya, Y, Hara, M, Nishida, Y, Takeuchi, K, Wakai, K, Matsuda, K, Murakami, Y, Shimizu, K, Suzuki, H, Saito, M, Ohtaki, Y, Tanaka, K, Wu, T, Wei, F, Dai, H, Machiela, MJ, Su, J, Kim, YH, Oh, IJ, Lee, VHF, Chang, GC, Tsai, YH, Chen, KY, Huang, MS, Su, WC, Chen, YM, Seow, A, Park, JY, Kweon, SS, Chen, KC, Gao, YT, Qian, B, Wu, C, Lu, D, Liu, J, Schwartz, AG, Houlston, R, Spitz, MR, Gorlov, IP, Wu, X, Yang, P, Lam, S, Tardon, A, Chen, C
, Bojesen, SE, Johansson, M, Risch, A, Bickeböller, H, Ji, BT, Wichmann, HE, Christiani, DC, Rennert, G, Arnold, S, Brennan, P, McKay, J, Field, JK, Shete, SS, Le Marchand, L, Liu, G, Andrew, A, Kiemeney, LA, Zienolddiny-Narui, S, Grankvist, K, Johansson, M, Cox, A, Taylor, F, Yuan, JM, Lazarus, P, Schabath, MB, Aldrich, MC, Jeon, HS, Jiang, SS, Sung, JS, Chen, CH, Hsiao, CF, Jung, YJ, Guo, H, Hu, Z, Burdett, L, Yeager, M, Hutchinson, A, Hicks, B, Liu, J, Zhu, B, Berndt, SI, Wu, W, Wang, J, Li, Y, Choi, JE, Park, KH, Sung, SW, Liu, L, Kang, CH, Wang, WC, Xu, J, Guan, P, Tan, W, Yu, CJ, Yang, G, Sihoe, ADL, Chen, Y, Choi, YY, Kim, JS, Yoon, HI, Park, IK, Xu, P, He, Q, Wang, CL, Hung, HH, Vermeulen, RCH, Cheng, I, Wu, J, Lim, WY, Tsai, FY, Chan, JKC, Li, J, Chen, H, Lin, HC, Jin, L, Liu, J, Sawada, N, Yamaji, T, Wyatt, K, Li, SA, Ma, H, Zhu, M, Wang, Z, Cheng, S, Li, X, Ren, Y, Chao, A, Iwasaki, M, Zhu, J, Jiang, G, Fei, K, Wu, G, Chen, CY, Chen, CJ, Yang, PC, Yu, J, Stevens, VL, Fraumeni, JF, Chatterjee, N, Gorlova, OY, Hsiung, CA, Amos, CI, Shen, H, Chanock, SJ, Rothman, N, Kohno, T & Lan, Q 2023, '
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population',
Nature Communications, bind 14, nr. 1, 3043.
https://doi.org/10.1038/s41467-023-38196-z
APA
Shi, J., Shiraishi, K., Choi, J., Matsuo, K., Chen, T. Y., Dai, J., Hung, R. J., Chen, K., Shu, X. O., Kim, Y. T., Landi, M. T., Lin, D., Zheng, W., Yin, Z., Zhou, B., Song, B., Wang, J., Seow, W. J., Song, L., ... Lan, Q. (2023).
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.
Nature Communications,
14(1), [3043].
https://doi.org/10.1038/s41467-023-38196-z
Vancouver
Shi J, Shiraishi K, Choi J, Matsuo K, Chen TY, Dai J o.a.
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.
Nature Communications. 2023;14(1). 3043.
https://doi.org/10.1038/s41467-023-38196-z
Author
Shi, Jianxin ; Shiraishi, Kouya ; Choi, Jiyeon ; Matsuo, Keitaro ; Chen, Tzu Yu ; Dai, Juncheng ; Hung, Rayjean J. ; Chen, Kexin ; Shu, Xiao Ou ; Kim, Young Tae ; Landi, Maria Teresa ; Lin, Dongxin ; Zheng, Wei ; Yin, Zhihua ; Zhou, Baosen ; Song, Bao ; Wang, Jiucun ; Seow, Wei Jie ; Song, Lei ; Chang, I. Shou ; Hu, Wei ; Chien, Li Hsin ; Cai, Qiuyin ; Hong, Yun Chul ; Kim, Hee Nam ; Wu, Yi Long ; Wong, Maria Pik ; Richardson, Brian Douglas ; Funderburk, Karen M. ; Li, Shilan ; Zhang, Tongwu ; Breeze, Charles ; Wang, Zhaoming ; Blechter, Batel ; Bassig, Bryan A. ; Kim, Jin Hee ; Albanes, Demetrius ; Wong, Jason Y.Y. ; Shin, Min Ho ; Chung, Lap Ping ; Yang, Yang ; An, She Juan ; Zheng, Hong ; Yatabe, Yasushi ; Zhang, Xu Chao ; Kim, Young Chul ; Caporaso, Neil E. ; Chang, Jiang ; Ho, James Chung Man ; Kubo, Michiaki ; Daigo, Yataro ; Song, Minsun ; Momozawa, Yukihide ; Kamatani, Yoichiro ; Kobayashi, Masashi ; Okubo, Kenichi ; Honda, Takayuki ; Hosgood, Dean H. ; Kunitoh, Hideo ; Patel, Harsh ; Watanabe, Shun ichi ; Miyagi, Yohei ; Nakayama, Haruhiko ; Matsumoto, Shingo ; Horinouchi, Hidehito ; Tsuboi, Masahiro ; Hamamoto, Ryuji ; Goto, Koichi ; Ohe, Yuichiro ; Takahashi, Atsushi ; Goto, Akiteru ; Minamiya, Yoshihiro ; Hara, Megumi ; Nishida, Yuichiro ; Takeuchi, Kenji ; Wakai, Kenji ; Matsuda, Koichi ; Murakami, Yoshinori ; Shimizu, Kimihiro ; Suzuki, Hiroyuki ; Saito, Motonobu ; Ohtaki, Yoichi ; Tanaka, Kazumi ; Wu, Tangchun ; Wei, Fusheng ; Dai, Hongji ; Machiela, Mitchell J. ; Su, Jian ; Kim, Yeul Hong ; Oh, In Jae ; Lee, Victor Ho Fun ; Chang, Gee Chen ; Tsai, Ying Huang ; Chen, Kuan Yu ; Huang, Ming Shyan ; Su, Wu Chou ; Chen, Yuh Min ; Seow, Adeline ; Park, Jae Yong ; Kweon, Sun Seog ; Chen, Kun Chieh ; Gao, Yu Tang ; Qian, Biyun ; Wu, Chen ; Lu, Daru ; Liu, Jianjun ; Schwartz, Ann G. ; Houlston, Richard ; Spitz, Margaret R. ; Gorlov, Ivan P. ; Wu, Xifeng ; Yang, Ping ; Lam, Stephen ; Tardon, Adonina ; Chen, Chu ; Bojesen, Stig E. ; Johansson, Mattias ; Risch, Angela ; Bickeböller, Heike ; Ji, Bu Tian ; Wichmann, H. Erich ; Christiani, David C. ; Rennert, Gadi ; Arnold, Susanne ; Brennan, Paul ; McKay, James ; Field, John K. ; Shete, Sanjay S. ; Le Marchand, Loic ; Liu, Geoffrey ; Andrew, Angeline ; Kiemeney, Lambertus A. ; Zienolddiny-Narui, Shan ; Grankvist, Kjell ; Johansson, Mikael ; Cox, Angela ; Taylor, Fiona ; Yuan, Jian Min ; Lazarus, Philip ; Schabath, Matthew B. ; Aldrich, Melinda C. ; Jeon, Hyo Sung ; Jiang, Shih Sheng ; Sung, Jae Sook ; Chen, Chung Hsing ; Hsiao, Chin Fu ; Jung, Yoo Jin ; Guo, Huan ; Hu, Zhibin ; Burdett, Laurie ; Yeager, Meredith ; Hutchinson, Amy ; Hicks, Belynda ; Liu, Jia ; Zhu, Bin ; Berndt, Sonja I. ; Wu, Wei ; Wang, Junwen ; Li, Yuqing ; Choi, Jin Eun ; Park, Kyong Hwa ; Sung, Sook Whan ; Liu, Li ; Kang, Chang Hyun ; Wang, Wen Chang ; Xu, Jun ; Guan, Peng ; Tan, Wen ; Yu, Chong Jen ; Yang, Gong ; Sihoe, Alan Dart Loon ; Chen, Ying ; Choi, Yi Young ; Kim, Jun Suk ; Yoon, Ho Il ; Park, In Kyu ; Xu, Ping ; He, Qincheng ; Wang, Chih Liang ; Hung, Hsiao Han ; Vermeulen, Roel C.H. ; Cheng, Iona ; Wu, Junjie ; Lim, Wei Yen ; Tsai, Fang Yu ; Chan, John K.C. ; Li, Jihua ; Chen, Hongyan ; Lin, Hsien Chih ; Jin, Li ; Liu, Jie ; Sawada, Norie ; Yamaji, Taiki ; Wyatt, Kathleen ; Li, Shengchao A. ; Ma, Hongxia ; Zhu, Meng ; Wang, Zhehai ; Cheng, Sensen ; Li, Xuelian ; Ren, Yangwu ; Chao, Ann ; Iwasaki, Motoki ; Zhu, Junjie ; Jiang, Gening ; Fei, Ke ; Wu, Guoping ; Chen, Chih Yi ; Chen, Chien Jen ; Yang, Pan Chyr ; Yu, Jinming ; Stevens, Victoria L. ; Fraumeni, Joseph F. ; Chatterjee, Nilanjan ; Gorlova, Olga Y. ; Hsiung, Chao Agnes ; Amos, Christopher I. ; Shen, Hongbing ; Chanock, Stephen J. ; Rothman, Nathaniel ; Kohno, Takashi ; Lan, Qing. / Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population. I: Nature Communications. 2023 ; Bind 14, Nr. 1.
Bibtex
@article{f097a1d2c27445f2955b53a057b5cbce,
title = "Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population",
abstract = "Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.",
author = "Jianxin Shi and Kouya Shiraishi and Jiyeon Choi and Keitaro Matsuo and Chen, {Tzu Yu} and Juncheng Dai and Hung, {Rayjean J.} and Kexin Chen and Shu, {Xiao Ou} and Kim, {Young Tae} and Landi, {Maria Teresa} and Dongxin Lin and Wei Zheng and Zhihua Yin and Baosen Zhou and Bao Song and Jiucun Wang and Seow, {Wei Jie} and Lei Song and Chang, {I. Shou} and Wei Hu and Chien, {Li Hsin} and Qiuyin Cai and Hong, {Yun Chul} and Kim, {Hee Nam} and Wu, {Yi Long} and Wong, {Maria Pik} and Richardson, {Brian Douglas} and Funderburk, {Karen M.} and Shilan Li and Tongwu Zhang and Charles Breeze and Zhaoming Wang and Batel Blechter and Bassig, {Bryan A.} and Kim, {Jin Hee} and Demetrius Albanes and Wong, {Jason Y.Y.} and Shin, {Min Ho} and Chung, {Lap Ping} and Yang Yang and An, {She Juan} and Hong Zheng and Yasushi Yatabe and Zhang, {Xu Chao} and Kim, {Young Chul} and Caporaso, {Neil E.} and Jiang Chang and Ho, {James Chung Man} and Michiaki Kubo and Yataro Daigo and Minsun Song and Yukihide Momozawa and Yoichiro Kamatani and Masashi Kobayashi and Kenichi Okubo and Takayuki Honda and Hosgood, {Dean H.} and Hideo Kunitoh and Harsh Patel and Watanabe, {Shun ichi} and Yohei Miyagi and Haruhiko Nakayama and Shingo Matsumoto and Hidehito Horinouchi and Masahiro Tsuboi and Ryuji Hamamoto and Koichi Goto and Yuichiro Ohe and Atsushi Takahashi and Akiteru Goto and Yoshihiro Minamiya and Megumi Hara and Yuichiro Nishida and Kenji Takeuchi and Kenji Wakai and Koichi Matsuda and Yoshinori Murakami and Kimihiro Shimizu and Hiroyuki Suzuki and Motonobu Saito and Yoichi Ohtaki and Kazumi Tanaka and Tangchun Wu and Fusheng Wei and Hongji Dai and Machiela, {Mitchell J.} and Jian Su and Kim, {Yeul Hong} and Oh, {In Jae} and Lee, {Victor Ho Fun} and Chang, {Gee Chen} and Tsai, {Ying Huang} and Chen, {Kuan Yu} and Huang, {Ming Shyan} and Su, {Wu Chou} and Chen, {Yuh Min} and Adeline Seow and Park, {Jae Yong} and Kweon, {Sun Seog} and Chen, {Kun Chieh} and Gao, {Yu Tang} and Biyun Qian and Chen Wu and Daru Lu and Jianjun Liu and Schwartz, {Ann G.} and Richard Houlston and Spitz, {Margaret R.} and Gorlov, {Ivan P.} and Xifeng Wu and Ping Yang and Stephen Lam and Adonina Tardon and Chu Chen and Bojesen, {Stig E.} and Mattias Johansson and Angela Risch and Heike Bickeb{\"o}ller and Ji, {Bu Tian} and Wichmann, {H. Erich} and Christiani, {David C.} and Gadi Rennert and Susanne Arnold and Paul Brennan and James McKay and Field, {John K.} and Shete, {Sanjay S.} and {Le Marchand}, Loic and Geoffrey Liu and Angeline Andrew and Kiemeney, {Lambertus A.} and Shan Zienolddiny-Narui and Kjell Grankvist and Mikael Johansson and Angela Cox and Fiona Taylor and Yuan, {Jian Min} and Philip Lazarus and Schabath, {Matthew B.} and Aldrich, {Melinda C.} and Jeon, {Hyo Sung} and Jiang, {Shih Sheng} and Sung, {Jae Sook} and Chen, {Chung Hsing} and Hsiao, {Chin Fu} and Jung, {Yoo Jin} and Huan Guo and Zhibin Hu and Laurie Burdett and Meredith Yeager and Amy Hutchinson and Belynda Hicks and Jia Liu and Bin Zhu and Berndt, {Sonja I.} and Wei Wu and Junwen Wang and Yuqing Li and Choi, {Jin Eun} and Park, {Kyong Hwa} and Sung, {Sook Whan} and Li Liu and Kang, {Chang Hyun} and Wang, {Wen Chang} and Jun Xu and Peng Guan and Wen Tan and Yu, {Chong Jen} and Gong Yang and Sihoe, {Alan Dart Loon} and Ying Chen and Choi, {Yi Young} and Kim, {Jun Suk} and Yoon, {Ho Il} and Park, {In Kyu} and Ping Xu and Qincheng He and Wang, {Chih Liang} and Hung, {Hsiao Han} and Vermeulen, {Roel C.H.} and Iona Cheng and Junjie Wu and Lim, {Wei Yen} and Tsai, {Fang Yu} and Chan, {John K.C.} and Jihua Li and Hongyan Chen and Lin, {Hsien Chih} and Li Jin and Jie Liu and Norie Sawada and Taiki Yamaji and Kathleen Wyatt and Li, {Shengchao A.} and Hongxia Ma and Meng Zhu and Zhehai Wang and Sensen Cheng and Xuelian Li and Yangwu Ren and Ann Chao and Motoki Iwasaki and Junjie Zhu and Gening Jiang and Ke Fei and Guoping Wu and Chen, {Chih Yi} and Chen, {Chien Jen} and Yang, {Pan Chyr} and Jinming Yu and Stevens, {Victoria L.} and Fraumeni, {Joseph F.} and Nilanjan Chatterjee and Gorlova, {Olga Y.} and Hsiung, {Chao Agnes} and Amos, {Christopher I.} and Hongbing Shen and Chanock, {Stephen J.} and Nathaniel Rothman and Takashi Kohno and Qing Lan",
note = "Publisher Copyright: {\textcopyright} 2023, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.",
year = "2023",
doi = "10.1038/s41467-023-38196-z",
language = "English",
volume = "14",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",
}
RIS
TY - JOUR
T1 - Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
AU - Shi, Jianxin
AU - Shiraishi, Kouya
AU - Choi, Jiyeon
AU - Matsuo, Keitaro
AU - Chen, Tzu Yu
AU - Dai, Juncheng
AU - Hung, Rayjean J.
AU - Chen, Kexin
AU - Shu, Xiao Ou
AU - Kim, Young Tae
AU - Landi, Maria Teresa
AU - Lin, Dongxin
AU - Zheng, Wei
AU - Yin, Zhihua
AU - Zhou, Baosen
AU - Song, Bao
AU - Wang, Jiucun
AU - Seow, Wei Jie
AU - Song, Lei
AU - Chang, I. Shou
AU - Hu, Wei
AU - Chien, Li Hsin
AU - Cai, Qiuyin
AU - Hong, Yun Chul
AU - Kim, Hee Nam
AU - Wu, Yi Long
AU - Wong, Maria Pik
AU - Richardson, Brian Douglas
AU - Funderburk, Karen M.
AU - Li, Shilan
AU - Zhang, Tongwu
AU - Breeze, Charles
AU - Wang, Zhaoming
AU - Blechter, Batel
AU - Bassig, Bryan A.
AU - Kim, Jin Hee
AU - Albanes, Demetrius
AU - Wong, Jason Y.Y.
AU - Shin, Min Ho
AU - Chung, Lap Ping
AU - Yang, Yang
AU - An, She Juan
AU - Zheng, Hong
AU - Yatabe, Yasushi
AU - Zhang, Xu Chao
AU - Kim, Young Chul
AU - Caporaso, Neil E.
AU - Chang, Jiang
AU - Ho, James Chung Man
AU - Kubo, Michiaki
AU - Daigo, Yataro
AU - Song, Minsun
AU - Momozawa, Yukihide
AU - Kamatani, Yoichiro
AU - Kobayashi, Masashi
AU - Okubo, Kenichi
AU - Honda, Takayuki
AU - Hosgood, Dean H.
AU - Kunitoh, Hideo
AU - Patel, Harsh
AU - Watanabe, Shun ichi
AU - Miyagi, Yohei
AU - Nakayama, Haruhiko
AU - Matsumoto, Shingo
AU - Horinouchi, Hidehito
AU - Tsuboi, Masahiro
AU - Hamamoto, Ryuji
AU - Goto, Koichi
AU - Ohe, Yuichiro
AU - Takahashi, Atsushi
AU - Goto, Akiteru
AU - Minamiya, Yoshihiro
AU - Hara, Megumi
AU - Nishida, Yuichiro
AU - Takeuchi, Kenji
AU - Wakai, Kenji
AU - Matsuda, Koichi
AU - Murakami, Yoshinori
AU - Shimizu, Kimihiro
AU - Suzuki, Hiroyuki
AU - Saito, Motonobu
AU - Ohtaki, Yoichi
AU - Tanaka, Kazumi
AU - Wu, Tangchun
AU - Wei, Fusheng
AU - Dai, Hongji
AU - Machiela, Mitchell J.
AU - Su, Jian
AU - Kim, Yeul Hong
AU - Oh, In Jae
AU - Lee, Victor Ho Fun
AU - Chang, Gee Chen
AU - Tsai, Ying Huang
AU - Chen, Kuan Yu
AU - Huang, Ming Shyan
AU - Su, Wu Chou
AU - Chen, Yuh Min
AU - Seow, Adeline
AU - Park, Jae Yong
AU - Kweon, Sun Seog
AU - Chen, Kun Chieh
AU - Gao, Yu Tang
AU - Qian, Biyun
AU - Wu, Chen
AU - Lu, Daru
AU - Liu, Jianjun
AU - Schwartz, Ann G.
AU - Houlston, Richard
AU - Spitz, Margaret R.
AU - Gorlov, Ivan P.
AU - Wu, Xifeng
AU - Yang, Ping
AU - Lam, Stephen
AU - Tardon, Adonina
AU - Chen, Chu
AU - Bojesen, Stig E.
AU - Johansson, Mattias
AU - Risch, Angela
AU - Bickeböller, Heike
AU - Ji, Bu Tian
AU - Wichmann, H. Erich
AU - Christiani, David C.
AU - Rennert, Gadi
AU - Arnold, Susanne
AU - Brennan, Paul
AU - McKay, James
AU - Field, John K.
AU - Shete, Sanjay S.
AU - Le Marchand, Loic
AU - Liu, Geoffrey
AU - Andrew, Angeline
AU - Kiemeney, Lambertus A.
AU - Zienolddiny-Narui, Shan
AU - Grankvist, Kjell
AU - Johansson, Mikael
AU - Cox, Angela
AU - Taylor, Fiona
AU - Yuan, Jian Min
AU - Lazarus, Philip
AU - Schabath, Matthew B.
AU - Aldrich, Melinda C.
AU - Jeon, Hyo Sung
AU - Jiang, Shih Sheng
AU - Sung, Jae Sook
AU - Chen, Chung Hsing
AU - Hsiao, Chin Fu
AU - Jung, Yoo Jin
AU - Guo, Huan
AU - Hu, Zhibin
AU - Burdett, Laurie
AU - Yeager, Meredith
AU - Hutchinson, Amy
AU - Hicks, Belynda
AU - Liu, Jia
AU - Zhu, Bin
AU - Berndt, Sonja I.
AU - Wu, Wei
AU - Wang, Junwen
AU - Li, Yuqing
AU - Choi, Jin Eun
AU - Park, Kyong Hwa
AU - Sung, Sook Whan
AU - Liu, Li
AU - Kang, Chang Hyun
AU - Wang, Wen Chang
AU - Xu, Jun
AU - Guan, Peng
AU - Tan, Wen
AU - Yu, Chong Jen
AU - Yang, Gong
AU - Sihoe, Alan Dart Loon
AU - Chen, Ying
AU - Choi, Yi Young
AU - Kim, Jun Suk
AU - Yoon, Ho Il
AU - Park, In Kyu
AU - Xu, Ping
AU - He, Qincheng
AU - Wang, Chih Liang
AU - Hung, Hsiao Han
AU - Vermeulen, Roel C.H.
AU - Cheng, Iona
AU - Wu, Junjie
AU - Lim, Wei Yen
AU - Tsai, Fang Yu
AU - Chan, John K.C.
AU - Li, Jihua
AU - Chen, Hongyan
AU - Lin, Hsien Chih
AU - Jin, Li
AU - Liu, Jie
AU - Sawada, Norie
AU - Yamaji, Taiki
AU - Wyatt, Kathleen
AU - Li, Shengchao A.
AU - Ma, Hongxia
AU - Zhu, Meng
AU - Wang, Zhehai
AU - Cheng, Sensen
AU - Li, Xuelian
AU - Ren, Yangwu
AU - Chao, Ann
AU - Iwasaki, Motoki
AU - Zhu, Junjie
AU - Jiang, Gening
AU - Fei, Ke
AU - Wu, Guoping
AU - Chen, Chih Yi
AU - Chen, Chien Jen
AU - Yang, Pan Chyr
AU - Yu, Jinming
AU - Stevens, Victoria L.
AU - Fraumeni, Joseph F.
AU - Chatterjee, Nilanjan
AU - Gorlova, Olga Y.
AU - Hsiung, Chao Agnes
AU - Amos, Christopher I.
AU - Shen, Hongbing
AU - Chanock, Stephen J.
AU - Rothman, Nathaniel
AU - Kohno, Takashi
AU - Lan, Qing
N1 - Publisher Copyright:
© 2023, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
PY - 2023
Y1 - 2023
N2 - Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.
AB - Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.
U2 - 10.1038/s41467-023-38196-z
DO - 10.1038/s41467-023-38196-z
M3 - Journal article
C2 - 37236969
AN - SCOPUS:85160220141
VL - 14
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 3043
ER -