Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk

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Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk. / Li, Yafang; Xiao, Xiangjun; Li, Jianrong; Byun, Jinyoung; Cheng, Chao; Bossé, Yohan; McKay, James; Albanes, Demetrios; Lam, Stephen; Tardon, Adonina; Chen, Chu; Bojesen, Stig E.; Landi, Maria T.; Johansson, Mattias; Risch, Angela; Bickeböller, Heike; Wichmann, H. Erich; Christiani, David C.; Rennert, Gad; Arnold, Susanne; Goodman, Gary; Field, John K.; Davies, Michael P.A.; Shete, Sanjay S.; Le Marchand, Loic; Melander, Olle; Brunnström, Hans; Liu, Geoffrey; Hung, Rayjean J.; Andrew, Angeline S.; Kiemeney, Lambertus A.; Shen, Hongbing; Sun, Ryan; Zienolddiny, Shan; Grankvist, Kjell; Johansson, Mikael; Caporaso, Neil; Teare, Dawn M.; Hong, Yun Chul; Lazarus, Philip; Schabath, Matthew B.; Aldrich, Melinda C.; Schwartz, Ann G.; Gorlov, Ivan; Purrington, Kristen; Yang, Ping; Liu, Yanhong; Han, Younghun; Bailey-Wilson, Joan E.; Pinney, Susan M.; INTEGRAL-ILCCO lung cancer consortium.

I: Human Molecular Genetics, Bind 31, Nr. 16, 2022, s. 2831-2843.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Li, Y, Xiao, X, Li, J, Byun, J, Cheng, C, Bossé, Y, McKay, J, Albanes, D, Lam, S, Tardon, A, Chen, C, Bojesen, SE, Landi, MT, Johansson, M, Risch, A, Bickeböller, H, Wichmann, HE, Christiani, DC, Rennert, G, Arnold, S, Goodman, G, Field, JK, Davies, MPA, Shete, SS, Le Marchand, L, Melander, O, Brunnström, H, Liu, G, Hung, RJ, Andrew, AS, Kiemeney, LA, Shen, H, Sun, R, Zienolddiny, S, Grankvist, K, Johansson, M, Caporaso, N, Teare, DM, Hong, YC, Lazarus, P, Schabath, MB, Aldrich, MC, Schwartz, AG, Gorlov, I, Purrington, K, Yang, P, Liu, Y, Han, Y, Bailey-Wilson, JE, Pinney, SM & INTEGRAL-ILCCO lung cancer consortium 2022, 'Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk', Human Molecular Genetics, bind 31, nr. 16, s. 2831-2843. https://doi.org/10.1093/hmg/ddac030

APA

Li, Y., Xiao, X., Li, J., Byun, J., Cheng, C., Bossé, Y., McKay, J., Albanes, D., Lam, S., Tardon, A., Chen, C., Bojesen, S. E., Landi, M. T., Johansson, M., Risch, A., Bickeböller, H., Wichmann, H. E., Christiani, D. C., Rennert, G., ... INTEGRAL-ILCCO lung cancer consortium (2022). Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk. Human Molecular Genetics, 31(16), 2831-2843. https://doi.org/10.1093/hmg/ddac030

Vancouver

Li Y, Xiao X, Li J, Byun J, Cheng C, Bossé Y o.a. Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk. Human Molecular Genetics. 2022;31(16):2831-2843. https://doi.org/10.1093/hmg/ddac030

Author

Li, Yafang ; Xiao, Xiangjun ; Li, Jianrong ; Byun, Jinyoung ; Cheng, Chao ; Bossé, Yohan ; McKay, James ; Albanes, Demetrios ; Lam, Stephen ; Tardon, Adonina ; Chen, Chu ; Bojesen, Stig E. ; Landi, Maria T. ; Johansson, Mattias ; Risch, Angela ; Bickeböller, Heike ; Wichmann, H. Erich ; Christiani, David C. ; Rennert, Gad ; Arnold, Susanne ; Goodman, Gary ; Field, John K. ; Davies, Michael P.A. ; Shete, Sanjay S. ; Le Marchand, Loic ; Melander, Olle ; Brunnström, Hans ; Liu, Geoffrey ; Hung, Rayjean J. ; Andrew, Angeline S. ; Kiemeney, Lambertus A. ; Shen, Hongbing ; Sun, Ryan ; Zienolddiny, Shan ; Grankvist, Kjell ; Johansson, Mikael ; Caporaso, Neil ; Teare, Dawn M. ; Hong, Yun Chul ; Lazarus, Philip ; Schabath, Matthew B. ; Aldrich, Melinda C. ; Schwartz, Ann G. ; Gorlov, Ivan ; Purrington, Kristen ; Yang, Ping ; Liu, Yanhong ; Han, Younghun ; Bailey-Wilson, Joan E. ; Pinney, Susan M. ; INTEGRAL-ILCCO lung cancer consortium. / Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk. I: Human Molecular Genetics. 2022 ; Bind 31, Nr. 16. s. 2831-2843.

Bibtex

@article{4718025f398043d7b2e51424249d20df,
title = "Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk",
abstract = "Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adopting a stringent two-stage analysis strategy, we performed a genome-wide gene-sex interaction analysis using genotypes from a lung cancer cohort including ~ 47 000 individuals with European ancestry. Three low-frequency variants (minor allele frequency < 0.05), rs17662871 [odds ratio (OR) = 0.71, P = 4.29×10-8); rs79942605 (OR = 2.17, P = 2.81×10-8) and rs208908 (OR = 0.70, P = 4.54×10-8) were identified with different risk effect of lung cancer between men and women. Further expression quantitative trait loci and functional annotation analysis suggested rs208908 affects lung cancer risk through differential regulation of Coxsackie virus and adenovirus receptor gene expression in lung tissues between men and women. Our study is one of the first studies to provide novel insights about the genetic and molecular basis for sex disparity in lung cancer development.",
author = "Yafang Li and Xiangjun Xiao and Jianrong Li and Jinyoung Byun and Chao Cheng and Yohan Boss{\'e} and James McKay and Demetrios Albanes and Stephen Lam and Adonina Tardon and Chu Chen and Bojesen, {Stig E.} and Landi, {Maria T.} and Mattias Johansson and Angela Risch and Heike Bickeb{\"o}ller and Wichmann, {H. Erich} and Christiani, {David C.} and Gad Rennert and Susanne Arnold and Gary Goodman and Field, {John K.} and Davies, {Michael P.A.} and Shete, {Sanjay S.} and {Le Marchand}, Loic and Olle Melander and Hans Brunnstr{\"o}m and Geoffrey Liu and Hung, {Rayjean J.} and Andrew, {Angeline S.} and Kiemeney, {Lambertus A.} and Hongbing Shen and Ryan Sun and Shan Zienolddiny and Kjell Grankvist and Mikael Johansson and Neil Caporaso and Teare, {Dawn M.} and Hong, {Yun Chul} and Philip Lazarus and Schabath, {Matthew B.} and Aldrich, {Melinda C.} and Schwartz, {Ann G.} and Ivan Gorlov and Kristen Purrington and Ping Yang and Yanhong Liu and Younghun Han and Bailey-Wilson, {Joan E.} and Pinney, {Susan M.} and {INTEGRAL-ILCCO lung cancer consortium}",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2022. Published by Oxford University Press.",
year = "2022",
doi = "10.1093/hmg/ddac030",
language = "English",
volume = "31",
pages = "2831--2843",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "16",

}

RIS

TY - JOUR

T1 - Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk

AU - Li, Yafang

AU - Xiao, Xiangjun

AU - Li, Jianrong

AU - Byun, Jinyoung

AU - Cheng, Chao

AU - Bossé, Yohan

AU - McKay, James

AU - Albanes, Demetrios

AU - Lam, Stephen

AU - Tardon, Adonina

AU - Chen, Chu

AU - Bojesen, Stig E.

AU - Landi, Maria T.

AU - Johansson, Mattias

AU - Risch, Angela

AU - Bickeböller, Heike

AU - Wichmann, H. Erich

AU - Christiani, David C.

AU - Rennert, Gad

AU - Arnold, Susanne

AU - Goodman, Gary

AU - Field, John K.

AU - Davies, Michael P.A.

AU - Shete, Sanjay S.

AU - Le Marchand, Loic

AU - Melander, Olle

AU - Brunnström, Hans

AU - Liu, Geoffrey

AU - Hung, Rayjean J.

AU - Andrew, Angeline S.

AU - Kiemeney, Lambertus A.

AU - Shen, Hongbing

AU - Sun, Ryan

AU - Zienolddiny, Shan

AU - Grankvist, Kjell

AU - Johansson, Mikael

AU - Caporaso, Neil

AU - Teare, Dawn M.

AU - Hong, Yun Chul

AU - Lazarus, Philip

AU - Schabath, Matthew B.

AU - Aldrich, Melinda C.

AU - Schwartz, Ann G.

AU - Gorlov, Ivan

AU - Purrington, Kristen

AU - Yang, Ping

AU - Liu, Yanhong

AU - Han, Younghun

AU - Bailey-Wilson, Joan E.

AU - Pinney, Susan M.

AU - INTEGRAL-ILCCO lung cancer consortium

N1 - Publisher Copyright: © The Author(s) 2022. Published by Oxford University Press.

PY - 2022

Y1 - 2022

N2 - Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adopting a stringent two-stage analysis strategy, we performed a genome-wide gene-sex interaction analysis using genotypes from a lung cancer cohort including ~ 47 000 individuals with European ancestry. Three low-frequency variants (minor allele frequency < 0.05), rs17662871 [odds ratio (OR) = 0.71, P = 4.29×10-8); rs79942605 (OR = 2.17, P = 2.81×10-8) and rs208908 (OR = 0.70, P = 4.54×10-8) were identified with different risk effect of lung cancer between men and women. Further expression quantitative trait loci and functional annotation analysis suggested rs208908 affects lung cancer risk through differential regulation of Coxsackie virus and adenovirus receptor gene expression in lung tissues between men and women. Our study is one of the first studies to provide novel insights about the genetic and molecular basis for sex disparity in lung cancer development.

AB - Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adopting a stringent two-stage analysis strategy, we performed a genome-wide gene-sex interaction analysis using genotypes from a lung cancer cohort including ~ 47 000 individuals with European ancestry. Three low-frequency variants (minor allele frequency < 0.05), rs17662871 [odds ratio (OR) = 0.71, P = 4.29×10-8); rs79942605 (OR = 2.17, P = 2.81×10-8) and rs208908 (OR = 0.70, P = 4.54×10-8) were identified with different risk effect of lung cancer between men and women. Further expression quantitative trait loci and functional annotation analysis suggested rs208908 affects lung cancer risk through differential regulation of Coxsackie virus and adenovirus receptor gene expression in lung tissues between men and women. Our study is one of the first studies to provide novel insights about the genetic and molecular basis for sex disparity in lung cancer development.

U2 - 10.1093/hmg/ddac030

DO - 10.1093/hmg/ddac030

M3 - Journal article

C2 - 35138370

AN - SCOPUS:85137124752

VL - 31

SP - 2831

EP - 2843

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 16

ER -

ID: 335023778