Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

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Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility. / Kachuri, Linda; Johansson, Mattias; Rashkin, Sara R; Graff, Rebecca E; Bossé, Yohan; Manem, Venkata; Caporaso, Neil E; Landi, Maria Teresa; Christiani, David C; Vineis, Paolo; Liu, Geoffrey; Scelo, Ghislaine; Zaridze, David; Shete, Sanjay S; Albanes, Demetrius; Aldrich, Melinda C; Tardón, Adonina; Rennert, Gad; Chen, Chu; Goodman, Gary E; Doherty, Jennifer A; Bickeböller, Heike; Field, John K; Davies, Michael P; Dawn Teare, M; Kiemeney, Lambertus A; Bojesen, Stig E; Haugen, Aage; Zienolddiny, Shanbeh; Lam, Stephen; Le Marchand, Loïc; Cheng, Iona; Schabath, Matthew B; Duell, Eric J; Andrew, Angeline S; Manjer, Jonas; Lazarus, Philip; Arnold, Susanne; McKay, James D; Emami, Nima C; Warkentin, Matthew T; Brhane, Yonathan; Obeidat, Ma'en; Martin, Richard M; Relton, Caroline; Davey Smith, George; Haycock, Philip C; Amos, Christopher I; Brennan, Paul; Witte, John S; Hung, Rayjean J.

I: Nature Communications, Bind 11, 27, 2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Kachuri, L, Johansson, M, Rashkin, SR, Graff, RE, Bossé, Y, Manem, V, Caporaso, NE, Landi, MT, Christiani, DC, Vineis, P, Liu, G, Scelo, G, Zaridze, D, Shete, SS, Albanes, D, Aldrich, MC, Tardón, A, Rennert, G, Chen, C, Goodman, GE, Doherty, JA, Bickeböller, H, Field, JK, Davies, MP, Dawn Teare, M, Kiemeney, LA, Bojesen, SE, Haugen, A, Zienolddiny, S, Lam, S, Le Marchand, L, Cheng, I, Schabath, MB, Duell, EJ, Andrew, AS, Manjer, J, Lazarus, P, Arnold, S, McKay, JD, Emami, NC, Warkentin, MT, Brhane, Y, Obeidat, M, Martin, RM, Relton, C, Davey Smith, G, Haycock, PC, Amos, CI, Brennan, P, Witte, JS & Hung, RJ 2020, 'Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility', Nature Communications, bind 11, 27. https://doi.org/10.1038/s41467-019-13855-2

APA

Kachuri, L., Johansson, M., Rashkin, S. R., Graff, R. E., Bossé, Y., Manem, V., Caporaso, N. E., Landi, M. T., Christiani, D. C., Vineis, P., Liu, G., Scelo, G., Zaridze, D., Shete, S. S., Albanes, D., Aldrich, M. C., Tardón, A., Rennert, G., Chen, C., ... Hung, R. J. (2020). Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility. Nature Communications, 11, [27]. https://doi.org/10.1038/s41467-019-13855-2

Vancouver

Kachuri L, Johansson M, Rashkin SR, Graff RE, Bossé Y, Manem V o.a. Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility. Nature Communications. 2020;11. 27. https://doi.org/10.1038/s41467-019-13855-2

Author

Kachuri, Linda ; Johansson, Mattias ; Rashkin, Sara R ; Graff, Rebecca E ; Bossé, Yohan ; Manem, Venkata ; Caporaso, Neil E ; Landi, Maria Teresa ; Christiani, David C ; Vineis, Paolo ; Liu, Geoffrey ; Scelo, Ghislaine ; Zaridze, David ; Shete, Sanjay S ; Albanes, Demetrius ; Aldrich, Melinda C ; Tardón, Adonina ; Rennert, Gad ; Chen, Chu ; Goodman, Gary E ; Doherty, Jennifer A ; Bickeböller, Heike ; Field, John K ; Davies, Michael P ; Dawn Teare, M ; Kiemeney, Lambertus A ; Bojesen, Stig E ; Haugen, Aage ; Zienolddiny, Shanbeh ; Lam, Stephen ; Le Marchand, Loïc ; Cheng, Iona ; Schabath, Matthew B ; Duell, Eric J ; Andrew, Angeline S ; Manjer, Jonas ; Lazarus, Philip ; Arnold, Susanne ; McKay, James D ; Emami, Nima C ; Warkentin, Matthew T ; Brhane, Yonathan ; Obeidat, Ma'en ; Martin, Richard M ; Relton, Caroline ; Davey Smith, George ; Haycock, Philip C ; Amos, Christopher I ; Brennan, Paul ; Witte, John S ; Hung, Rayjean J. / Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility. I: Nature Communications. 2020 ; Bind 11.

Bibtex

@article{07141d121d6a47c6a1af1d5820919724,
title = "Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility",
abstract = "Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is genetically correlated with reduced forced expiratory volume in one second (FEV1: rg = 0.098, p = 2.3 × 10-8) and the ratio of FEV1 to forced vital capacity (FEV1/FVC: rg = 0.137, p = 2.0 × 10-12). Mendelian randomization analyses demonstrate that reduced FEV1 increases squamous cell carcinoma risk (odds ratio (OR) = 1.51, 95% confidence intervals: 1.21-1.88), while reduced FEV1/FVC increases the risk of adenocarcinoma (OR = 1.17, 1.01-1.35) and lung cancer in never smokers (OR = 1.56, 1.05-2.30). These findings support a causal role of pulmonary impairment in lung cancer etiology. Integrative analyses reveal that pulmonary function instruments, including 73 novel variants, influence lung tissue gene expression and implicate immune-related pathways in mediating the observed effects on lung carcinogenesis.",
keywords = "Adult, Aged, Female, Forced Expiratory Volume, Genetic Predisposition to Disease, Humans, Lung/physiopathology, Lung Neoplasms/genetics, Male, Mendelian Randomization Analysis, Middle Aged, Phenotype, Polymorphism, Single Nucleotide, Prospective Studies, Respiratory Function Tests, Vital Capacity",
author = "Linda Kachuri and Mattias Johansson and Rashkin, {Sara R} and Graff, {Rebecca E} and Yohan Boss{\'e} and Venkata Manem and Caporaso, {Neil E} and Landi, {Maria Teresa} and Christiani, {David C} and Paolo Vineis and Geoffrey Liu and Ghislaine Scelo and David Zaridze and Shete, {Sanjay S} and Demetrius Albanes and Aldrich, {Melinda C} and Adonina Tard{\'o}n and Gad Rennert and Chu Chen and Goodman, {Gary E} and Doherty, {Jennifer A} and Heike Bickeb{\"o}ller and Field, {John K} and Davies, {Michael P} and {Dawn Teare}, M and Kiemeney, {Lambertus A} and Bojesen, {Stig E} and Aage Haugen and Shanbeh Zienolddiny and Stephen Lam and {Le Marchand}, Lo{\"i}c and Iona Cheng and Schabath, {Matthew B} and Duell, {Eric J} and Andrew, {Angeline S} and Jonas Manjer and Philip Lazarus and Susanne Arnold and McKay, {James D} and Emami, {Nima C} and Warkentin, {Matthew T} and Yonathan Brhane and Ma'en Obeidat and Martin, {Richard M} and Caroline Relton and {Davey Smith}, George and Haycock, {Philip C} and Amos, {Christopher I} and Paul Brennan and Witte, {John S} and Hung, {Rayjean J}",
year = "2020",
doi = "10.1038/s41467-019-13855-2",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

AU - Kachuri, Linda

AU - Johansson, Mattias

AU - Rashkin, Sara R

AU - Graff, Rebecca E

AU - Bossé, Yohan

AU - Manem, Venkata

AU - Caporaso, Neil E

AU - Landi, Maria Teresa

AU - Christiani, David C

AU - Vineis, Paolo

AU - Liu, Geoffrey

AU - Scelo, Ghislaine

AU - Zaridze, David

AU - Shete, Sanjay S

AU - Albanes, Demetrius

AU - Aldrich, Melinda C

AU - Tardón, Adonina

AU - Rennert, Gad

AU - Chen, Chu

AU - Goodman, Gary E

AU - Doherty, Jennifer A

AU - Bickeböller, Heike

AU - Field, John K

AU - Davies, Michael P

AU - Dawn Teare, M

AU - Kiemeney, Lambertus A

AU - Bojesen, Stig E

AU - Haugen, Aage

AU - Zienolddiny, Shanbeh

AU - Lam, Stephen

AU - Le Marchand, Loïc

AU - Cheng, Iona

AU - Schabath, Matthew B

AU - Duell, Eric J

AU - Andrew, Angeline S

AU - Manjer, Jonas

AU - Lazarus, Philip

AU - Arnold, Susanne

AU - McKay, James D

AU - Emami, Nima C

AU - Warkentin, Matthew T

AU - Brhane, Yonathan

AU - Obeidat, Ma'en

AU - Martin, Richard M

AU - Relton, Caroline

AU - Davey Smith, George

AU - Haycock, Philip C

AU - Amos, Christopher I

AU - Brennan, Paul

AU - Witte, John S

AU - Hung, Rayjean J

PY - 2020

Y1 - 2020

N2 - Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is genetically correlated with reduced forced expiratory volume in one second (FEV1: rg = 0.098, p = 2.3 × 10-8) and the ratio of FEV1 to forced vital capacity (FEV1/FVC: rg = 0.137, p = 2.0 × 10-12). Mendelian randomization analyses demonstrate that reduced FEV1 increases squamous cell carcinoma risk (odds ratio (OR) = 1.51, 95% confidence intervals: 1.21-1.88), while reduced FEV1/FVC increases the risk of adenocarcinoma (OR = 1.17, 1.01-1.35) and lung cancer in never smokers (OR = 1.56, 1.05-2.30). These findings support a causal role of pulmonary impairment in lung cancer etiology. Integrative analyses reveal that pulmonary function instruments, including 73 novel variants, influence lung tissue gene expression and implicate immune-related pathways in mediating the observed effects on lung carcinogenesis.

AB - Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is genetically correlated with reduced forced expiratory volume in one second (FEV1: rg = 0.098, p = 2.3 × 10-8) and the ratio of FEV1 to forced vital capacity (FEV1/FVC: rg = 0.137, p = 2.0 × 10-12). Mendelian randomization analyses demonstrate that reduced FEV1 increases squamous cell carcinoma risk (odds ratio (OR) = 1.51, 95% confidence intervals: 1.21-1.88), while reduced FEV1/FVC increases the risk of adenocarcinoma (OR = 1.17, 1.01-1.35) and lung cancer in never smokers (OR = 1.56, 1.05-2.30). These findings support a causal role of pulmonary impairment in lung cancer etiology. Integrative analyses reveal that pulmonary function instruments, including 73 novel variants, influence lung tissue gene expression and implicate immune-related pathways in mediating the observed effects on lung carcinogenesis.

KW - Adult

KW - Aged

KW - Female

KW - Forced Expiratory Volume

KW - Genetic Predisposition to Disease

KW - Humans

KW - Lung/physiopathology

KW - Lung Neoplasms/genetics

KW - Male

KW - Mendelian Randomization Analysis

KW - Middle Aged

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Prospective Studies

KW - Respiratory Function Tests

KW - Vital Capacity

U2 - 10.1038/s41467-019-13855-2

DO - 10.1038/s41467-019-13855-2

M3 - Journal article

C2 - 31911640

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 27

ER -

ID: 256323318