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Large-scale genotyping identifies 41 new loci associated with breast cancer risk. / Michailidou, Kyriaki; Hall, Per; Gonzalez-Neira, Anna; Ghoussaini, Maya; Dennis, Joe; Milne, Roger L; Schmidt, Marjanka K; Chang-Claude, Jenny; Bojesen, Stig E; Bolla, Manjeet K; Wang, Qin; Dicks, Ed; Lee, Andrew Roger; Turnbull, Clare; Rahman, Nazneen; Fletcher, Olivia; Peto, Julian; Gibson, Lorna; Dos Santos Silva, Isabel; Nevanlinna, Heli; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Czene, Kamila; Irwanto, Astrid; Liu, Jianjun; Waisfisz, Quinten; Meijers-Heijboer, Hanne; Adank, Muriel; van der Luijt, Rob B; Hein, Rebecca; Dahmen, Norbert; Beckman, Lars; Meindl, Alfons; Schmutzler, Rita K; Müller-Myhsok, Bertram; Lichtner, Peter; Hopper, John L; Southey, Melissa C; Makalic, Enes; Schmidt, Daniel F; Uitterlinden, Andre G; Hofman, Albert; Hunter, David J; Chanock, Stephen J; Vincent, Daniel; Bacot, François; Tessier, Daniel C; Canisius, Sander; Nordestgaard, Børge G; Breast and Ovarian Cancer Susceptibility Collaboration.
I:
Nature Genetics, Bind 45, Nr. 4, 04.2013, s. 353-61, 361e1-2.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Michailidou, K, Hall, P, Gonzalez-Neira, A, Ghoussaini, M, Dennis, J, Milne, RL, Schmidt, MK, Chang-Claude, J, Bojesen, SE, Bolla, MK, Wang, Q, Dicks, E, Lee, AR, Turnbull, C, Rahman, N, Fletcher, O, Peto, J, Gibson, L, Dos Santos Silva, I, Nevanlinna, H, Muranen, TA, Aittomäki, K, Blomqvist, C, Czene, K, Irwanto, A, Liu, J, Waisfisz, Q, Meijers-Heijboer, H, Adank, M, van der Luijt, RB, Hein, R, Dahmen, N, Beckman, L, Meindl, A, Schmutzler, RK, Müller-Myhsok, B, Lichtner, P, Hopper, JL, Southey, MC, Makalic, E, Schmidt, DF, Uitterlinden, AG, Hofman, A, Hunter, DJ, Chanock, SJ, Vincent, D, Bacot, F, Tessier, DC, Canisius, S
, Nordestgaard, BG & Breast and Ovarian Cancer Susceptibility Collaboration 2013, '
Large-scale genotyping identifies 41 new loci associated with breast cancer risk',
Nature Genetics, bind 45, nr. 4, s. 353-61, 361e1-2.
https://doi.org/10.1038/ng.2563APA
Michailidou, K., Hall, P., Gonzalez-Neira, A., Ghoussaini, M., Dennis, J., Milne, R. L., Schmidt, M. K., Chang-Claude, J., Bojesen, S. E., Bolla, M. K., Wang, Q., Dicks, E., Lee, A. R., Turnbull, C., Rahman, N., Fletcher, O., Peto, J., Gibson, L., Dos Santos Silva, I., ... Breast and Ovarian Cancer Susceptibility Collaboration (2013).
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Nature Genetics,
45(4), 353-61, 361e1-2.
https://doi.org/10.1038/ng.2563Vancouver
Michailidou K, Hall P, Gonzalez-Neira A, Ghoussaini M, Dennis J, Milne RL o.a.
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Nature Genetics. 2013 apr.;45(4):353-61, 361e1-2.
https://doi.org/10.1038/ng.2563Author
Michailidou, Kyriaki ; Hall, Per ; Gonzalez-Neira, Anna ; Ghoussaini, Maya ; Dennis, Joe ; Milne, Roger L ; Schmidt, Marjanka K ; Chang-Claude, Jenny ; Bojesen, Stig E ; Bolla, Manjeet K ; Wang, Qin ; Dicks, Ed ; Lee, Andrew Roger ; Turnbull, Clare ; Rahman, Nazneen ; Fletcher, Olivia ; Peto, Julian ; Gibson, Lorna ; Dos Santos Silva, Isabel ; Nevanlinna, Heli ; Muranen, Taru A ; Aittomäki, Kristiina ; Blomqvist, Carl ; Czene, Kamila ; Irwanto, Astrid ; Liu, Jianjun ; Waisfisz, Quinten ; Meijers-Heijboer, Hanne ; Adank, Muriel ; van der Luijt, Rob B ; Hein, Rebecca ; Dahmen, Norbert ; Beckman, Lars ; Meindl, Alfons ; Schmutzler, Rita K ; Müller-Myhsok, Bertram ; Lichtner, Peter ; Hopper, John L ; Southey, Melissa C ; Makalic, Enes ; Schmidt, Daniel F ; Uitterlinden, Andre G ; Hofman, Albert ; Hunter, David J ; Chanock, Stephen J ; Vincent, Daniel ; Bacot, François ; Tessier, Daniel C ; Canisius, Sander ; Nordestgaard, Børge G ; Breast and Ovarian Cancer Susceptibility Collaboration. / Large-scale genotyping identifies 41 new loci associated with breast cancer risk. I: Nature Genetics. 2013 ; Bind 45, Nr. 4. s. 353-61, 361e1-2.
Bibtex
@article{362198dc30fa451880a1e97de1ebcc83,
title = "Large-scale genotyping identifies 41 new loci associated with breast cancer risk",
abstract = "Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P <5 × 10(-8)). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.",
author = "Kyriaki Michailidou and Per Hall and Anna Gonzalez-Neira and Maya Ghoussaini and Joe Dennis and Milne, {Roger L} and Schmidt, {Marjanka K} and Jenny Chang-Claude and Bojesen, {Stig E} and Bolla, {Manjeet K} and Qin Wang and Ed Dicks and Lee, {Andrew Roger} and Clare Turnbull and Nazneen Rahman and Olivia Fletcher and Julian Peto and Lorna Gibson and {Dos Santos Silva}, Isabel and Heli Nevanlinna and Muranen, {Taru A} and Kristiina Aittom{\"a}ki and Carl Blomqvist and Kamila Czene and Astrid Irwanto and Jianjun Liu and Quinten Waisfisz and Hanne Meijers-Heijboer and Muriel Adank and {van der Luijt}, {Rob B} and Rebecca Hein and Norbert Dahmen and Lars Beckman and Alfons Meindl and Schmutzler, {Rita K} and Bertram M{\"u}ller-Myhsok and Peter Lichtner and Hopper, {John L} and Southey, {Melissa C} and Enes Makalic and Schmidt, {Daniel F} and Uitterlinden, {Andre G} and Albert Hofman and Hunter, {David J} and Chanock, {Stephen J} and Daniel Vincent and Fran{\c c}ois Bacot and Tessier, {Daniel C} and Sander Canisius and Nordestgaard, {B{\o}rge G} and B{\o}rge Nordestgaard",
year = "2013",
month = apr,
doi = "10.1038/ng.2563",
language = "English",
volume = "45",
pages = "353--61, 361e1--2",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "4",
}
RIS
TY - JOUR
T1 - Large-scale genotyping identifies 41 new loci associated with breast cancer risk
AU - Michailidou, Kyriaki
AU - Hall, Per
AU - Gonzalez-Neira, Anna
AU - Ghoussaini, Maya
AU - Dennis, Joe
AU - Milne, Roger L
AU - Schmidt, Marjanka K
AU - Chang-Claude, Jenny
AU - Bojesen, Stig E
AU - Bolla, Manjeet K
AU - Wang, Qin
AU - Dicks, Ed
AU - Lee, Andrew Roger
AU - Turnbull, Clare
AU - Rahman, Nazneen
AU - Fletcher, Olivia
AU - Peto, Julian
AU - Gibson, Lorna
AU - Dos Santos Silva, Isabel
AU - Nevanlinna, Heli
AU - Muranen, Taru A
AU - Aittomäki, Kristiina
AU - Blomqvist, Carl
AU - Czene, Kamila
AU - Irwanto, Astrid
AU - Liu, Jianjun
AU - Waisfisz, Quinten
AU - Meijers-Heijboer, Hanne
AU - Adank, Muriel
AU - van der Luijt, Rob B
AU - Hein, Rebecca
AU - Dahmen, Norbert
AU - Beckman, Lars
AU - Meindl, Alfons
AU - Schmutzler, Rita K
AU - Müller-Myhsok, Bertram
AU - Lichtner, Peter
AU - Hopper, John L
AU - Southey, Melissa C
AU - Makalic, Enes
AU - Schmidt, Daniel F
AU - Uitterlinden, Andre G
AU - Hofman, Albert
AU - Hunter, David J
AU - Chanock, Stephen J
AU - Vincent, Daniel
AU - Bacot, François
AU - Tessier, Daniel C
AU - Canisius, Sander
AU - Nordestgaard, Børge G
AU - Breast and Ovarian Cancer Susceptibility Collaboration
PY - 2013/4
Y1 - 2013/4
N2 - Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P <5 × 10(-8)). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.
AB - Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P <5 × 10(-8)). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.
U2 - 10.1038/ng.2563
DO - 10.1038/ng.2563
M3 - Journal article
C2 - 23535729
VL - 45
SP - 353-61, 361e1-2
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 4
ER -
