Lipoprotein(a) and risk of type 2 diabetes
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Lipoprotein(a) and risk of type 2 diabetes. / Mora, S.; Kamstrup, Pia R; Rifai, N.; Nordestgaard, Børge G; Buring, J.E.; Ridker, P.M.; Mora, Samia; Rifai, Nader; Buring, Julie E; Ridker, Paul M.
I: Clinical Chemistry, Bind 56, Nr. 8, 08.2010, s. 1252-60.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Lipoprotein(a) and risk of type 2 diabetes
AU - Mora, S.
AU - Kamstrup, Pia R
AU - Rifai, N.
AU - Nordestgaard, Børge G
AU - Buring, J.E.
AU - Ridker, P.M.
AU - Mora, Samia
AU - Rifai, Nader
AU - Buring, Julie E
AU - Ridker, Paul M
PY - 2010/8
Y1 - 2010/8
N2 - BACKGROUND: Previous studies have demonstrated that cardiovascular risk is higher with increased lipoprotein (a) [Lp(a)]. Whether Lp(a) concentration is related to type 2 diabetes is unclear. METHODS: In 26 746 healthy US women (mean age 54.6 years), we prospectively examined baseline Lp(a) concentrations and incident type 2 diabetes (n = 1670) for a follow-up period of 13 years. We confirmed our findings in 9652 Danish men and women with prevalent diabetes (n = 419). Analyses were adjusted for risk factors that included age, race, smoking, hormone use, family history, blood pressure, body mass index, hemoglobin A(1c) (Hb A(1c)), C-reactive protein, and lipids. RESULTS: Lp(a) was inversely associated with incident diabetes, with fully adjusted hazard ratios (HRs) and 95% CIs for quintiles 2-5 vs quintile 1 of 0.87 (0.75-1.01), 0.80 (0.68-0.93), 0.88 (0.76-1.02), and 0.78 (0.67-0.91); P for trend 0.002. The association was stronger in nonfasting women, for whom respective HRs were 0.79 (0.58-1.09), 0.78 (0.57-1.08), 0.66 (0.46-0.93), and 0.56 (0.40-0.80); P for trend 0.001; P for interaction with fasting status 0.002. When we used Lp(a) >= 10 mg/L and Hb A(1c) = 10 mg/L and Hb A(1c) 5%-
AB - BACKGROUND: Previous studies have demonstrated that cardiovascular risk is higher with increased lipoprotein (a) [Lp(a)]. Whether Lp(a) concentration is related to type 2 diabetes is unclear. METHODS: In 26 746 healthy US women (mean age 54.6 years), we prospectively examined baseline Lp(a) concentrations and incident type 2 diabetes (n = 1670) for a follow-up period of 13 years. We confirmed our findings in 9652 Danish men and women with prevalent diabetes (n = 419). Analyses were adjusted for risk factors that included age, race, smoking, hormone use, family history, blood pressure, body mass index, hemoglobin A(1c) (Hb A(1c)), C-reactive protein, and lipids. RESULTS: Lp(a) was inversely associated with incident diabetes, with fully adjusted hazard ratios (HRs) and 95% CIs for quintiles 2-5 vs quintile 1 of 0.87 (0.75-1.01), 0.80 (0.68-0.93), 0.88 (0.76-1.02), and 0.78 (0.67-0.91); P for trend 0.002. The association was stronger in nonfasting women, for whom respective HRs were 0.79 (0.58-1.09), 0.78 (0.57-1.08), 0.66 (0.46-0.93), and 0.56 (0.40-0.80); P for trend 0.001; P for interaction with fasting status 0.002. When we used Lp(a) >= 10 mg/L and Hb A(1c) = 10 mg/L and Hb A(1c) 5%-
U2 - http://dx.doi.org/10.1373/clinchem.2010.146779
DO - http://dx.doi.org/10.1373/clinchem.2010.146779
M3 - Journal article
VL - 56
SP - 1252
EP - 1260
JO - Clinical Chemistry
JF - Clinical Chemistry
SN - 0009-9147
IS - 8
ER -
ID: 34154699