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Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. / Ahmed, Shahana; Thomas, Gilles; Ghoussaini, Maya; Healey, Catherine S; Humphreys, Manjeet K; Platte, Radka; Morrison, Jonathan; Maranian, Melanie; Pooley, Karen A; Luben, Robert; Eccles, Diana; Evans, D Gareth; Fletcher, Olivia; Johnson, Nichola; dos Santos Silva, Isabel; Peto, Julian; Stratton, Michael R; Rahman, Nazneen; Jacobs, Kevin; Prentice, Ross; Anderson, Garnet L; Rajkovic, Aleksandar; Curb, J David; Ziegler, Regina G; Berg, Christine D; Buys, Saundra S; McCarty, Catherine A; Feigelson, Heather Spencer; Calle, Eugenia E; Thun, Michael J; Diver, W Ryan; Bojesen, Stig; Nordestgaard, Børge G; Flyger, Henrik; Dörk, Thilo; Schürmann, Peter; Hillemanns, Peter; Karstens, Johann H; Bogdanova, Natalia V; Antonenkova, Natalia N; Zalutsky, Iosif V; Bermisheva, Marina; Fedorova, Sardana; Khusnutdinova, Elza; SEARCH; Kang, Daehee; Yoo, Keun-Young; Noh, Dong Young; Ahn, Sei-Hyun; Devilee, Peter; van Asperen, Christi J; GENICA Consortium; kConFab; Australian Ovarian Cancer Study Group.
I:
Nature Genetics, Bind 41, Nr. 5, 2009, s. 585-90.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Ahmed, S, Thomas, G, Ghoussaini, M, Healey, CS, Humphreys, MK, Platte, R, Morrison, J, Maranian, M, Pooley, KA, Luben, R, Eccles, D, Evans, DG, Fletcher, O, Johnson, N, dos Santos Silva, I, Peto, J, Stratton, MR, Rahman, N, Jacobs, K, Prentice, R, Anderson, GL, Rajkovic, A, Curb, JD, Ziegler, RG, Berg, CD, Buys, SS, McCarty, CA, Feigelson, HS, Calle, EE, Thun, MJ, Diver, WR
, Bojesen, S, Nordestgaard, BG, Flyger, H, Dörk, T, Schürmann, P, Hillemanns, P, Karstens, JH, Bogdanova, NV, Antonenkova, NN, Zalutsky, IV, Bermisheva, M, Fedorova, S, Khusnutdinova, E, SEARCH, Kang, D, Yoo, K-Y, Noh, DY, Ahn, S-H, Devilee, P, van Asperen, CJ, GENICA Consortium, kConFab & Australian Ovarian Cancer Study Group 2009, '
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2',
Nature Genetics, bind 41, nr. 5, s. 585-90.
https://doi.org/10.1038/ng.354APA
Ahmed, S., Thomas, G., Ghoussaini, M., Healey, C. S., Humphreys, M. K., Platte, R., Morrison, J., Maranian, M., Pooley, K. A., Luben, R., Eccles, D., Evans, D. G., Fletcher, O., Johnson, N., dos Santos Silva, I., Peto, J., Stratton, M. R., Rahman, N., Jacobs, K., ... Australian Ovarian Cancer Study Group (2009).
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.
Nature Genetics,
41(5), 585-90.
https://doi.org/10.1038/ng.354Vancouver
Ahmed S, Thomas G, Ghoussaini M, Healey CS, Humphreys MK, Platte R o.a.
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.
Nature Genetics. 2009;41(5):585-90.
https://doi.org/10.1038/ng.354Author
Ahmed, Shahana ; Thomas, Gilles ; Ghoussaini, Maya ; Healey, Catherine S ; Humphreys, Manjeet K ; Platte, Radka ; Morrison, Jonathan ; Maranian, Melanie ; Pooley, Karen A ; Luben, Robert ; Eccles, Diana ; Evans, D Gareth ; Fletcher, Olivia ; Johnson, Nichola ; dos Santos Silva, Isabel ; Peto, Julian ; Stratton, Michael R ; Rahman, Nazneen ; Jacobs, Kevin ; Prentice, Ross ; Anderson, Garnet L ; Rajkovic, Aleksandar ; Curb, J David ; Ziegler, Regina G ; Berg, Christine D ; Buys, Saundra S ; McCarty, Catherine A ; Feigelson, Heather Spencer ; Calle, Eugenia E ; Thun, Michael J ; Diver, W Ryan ; Bojesen, Stig ; Nordestgaard, Børge G ; Flyger, Henrik ; Dörk, Thilo ; Schürmann, Peter ; Hillemanns, Peter ; Karstens, Johann H ; Bogdanova, Natalia V ; Antonenkova, Natalia N ; Zalutsky, Iosif V ; Bermisheva, Marina ; Fedorova, Sardana ; Khusnutdinova, Elza ; SEARCH ; Kang, Daehee ; Yoo, Keun-Young ; Noh, Dong Young ; Ahn, Sei-Hyun ; Devilee, Peter ; van Asperen, Christi J ; GENICA Consortium ; kConFab ; Australian Ovarian Cancer Study Group. / Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. I: Nature Genetics. 2009 ; Bind 41, Nr. 5. s. 585-90.
Bibtex
@article{5a083e50829211df928f000ea68e967b,
title = "Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2",
abstract = "Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08-1.13, P = 4.1 x 10(-23)) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92-0.97, P = 1.4 x 10(-8)). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q.",
author = "Shahana Ahmed and Gilles Thomas and Maya Ghoussaini and Healey, {Catherine S} and Humphreys, {Manjeet K} and Radka Platte and Jonathan Morrison and Melanie Maranian and Pooley, {Karen A} and Robert Luben and Diana Eccles and Evans, {D Gareth} and Olivia Fletcher and Nichola Johnson and {dos Santos Silva}, Isabel and Julian Peto and Stratton, {Michael R} and Nazneen Rahman and Kevin Jacobs and Ross Prentice and Anderson, {Garnet L} and Aleksandar Rajkovic and Curb, {J David} and Ziegler, {Regina G} and Berg, {Christine D} and Buys, {Saundra S} and McCarty, {Catherine A} and Feigelson, {Heather Spencer} and Calle, {Eugenia E} and Thun, {Michael J} and Diver, {W Ryan} and Stig Bojesen and Nordestgaard, {B{\o}rge G} and Henrik Flyger and Thilo D{\"o}rk and Peter Sch{\"u}rmann and Peter Hillemanns and Karstens, {Johann H} and Bogdanova, {Natalia V} and Antonenkova, {Natalia N} and Zalutsky, {Iosif V} and Marina Bermisheva and Sardana Fedorova and Elza Khusnutdinova and SEARCH and Daehee Kang and Keun-Young Yoo and Noh, {Dong Young} and Sei-Hyun Ahn and Peter Devilee and {van Asperen}, {Christi J} and {GENICA Consortium} and kConFab and {Australian Ovarian Cancer Study Group}",
note = "Keywords: Breast Neoplasms; Chromosome Mapping; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 3; Disease Susceptibility; Female; Genetic Predisposition to Disease; Genome, Human; Genotype; Humans",
year = "2009",
doi = "10.1038/ng.354",
language = "English",
volume = "41",
pages = "585--90",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "5",
}
RIS
TY - JOUR
T1 - Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2
AU - Ahmed, Shahana
AU - Thomas, Gilles
AU - Ghoussaini, Maya
AU - Healey, Catherine S
AU - Humphreys, Manjeet K
AU - Platte, Radka
AU - Morrison, Jonathan
AU - Maranian, Melanie
AU - Pooley, Karen A
AU - Luben, Robert
AU - Eccles, Diana
AU - Evans, D Gareth
AU - Fletcher, Olivia
AU - Johnson, Nichola
AU - dos Santos Silva, Isabel
AU - Peto, Julian
AU - Stratton, Michael R
AU - Rahman, Nazneen
AU - Jacobs, Kevin
AU - Prentice, Ross
AU - Anderson, Garnet L
AU - Rajkovic, Aleksandar
AU - Curb, J David
AU - Ziegler, Regina G
AU - Berg, Christine D
AU - Buys, Saundra S
AU - McCarty, Catherine A
AU - Feigelson, Heather Spencer
AU - Calle, Eugenia E
AU - Thun, Michael J
AU - Diver, W Ryan
AU - Bojesen, Stig
AU - Nordestgaard, Børge G
AU - Flyger, Henrik
AU - Dörk, Thilo
AU - Schürmann, Peter
AU - Hillemanns, Peter
AU - Karstens, Johann H
AU - Bogdanova, Natalia V
AU - Antonenkova, Natalia N
AU - Zalutsky, Iosif V
AU - Bermisheva, Marina
AU - Fedorova, Sardana
AU - Khusnutdinova, Elza
AU - SEARCH
AU - Kang, Daehee
AU - Yoo, Keun-Young
AU - Noh, Dong Young
AU - Ahn, Sei-Hyun
AU - Devilee, Peter
AU - van Asperen, Christi J
AU - GENICA Consortium
AU - kConFab
AU - Australian Ovarian Cancer Study Group
N1 - Keywords: Breast Neoplasms; Chromosome Mapping; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 3; Disease Susceptibility; Female; Genetic Predisposition to Disease; Genome, Human; Genotype; Humans
PY - 2009
Y1 - 2009
N2 - Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08-1.13, P = 4.1 x 10(-23)) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92-0.97, P = 1.4 x 10(-8)). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q.
AB - Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08-1.13, P = 4.1 x 10(-23)) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92-0.97, P = 1.4 x 10(-8)). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q.
U2 - 10.1038/ng.354
DO - 10.1038/ng.354
M3 - Journal article
C2 - 19330027
VL - 41
SP - 585
EP - 590
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 5
ER -
