Novel mutations in leukotriene C4 synthase and risk of cardiovascular disease based on genotypes from 50,000 individuals

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Atherosclerosis is an inflammatory condition where cysteinyl leukotrienes have been identified to play an important role. Furthermore, cysteinyl leukotrienes may also affect thrombus formation. Using prospective, cross-sectional and case-control designs, we tested the hypothesis that hitherto unknown genetic variation, likely to affect the function of leukotriene C(4) synthase, is associated with risk of venous thromboembolism, ischemic stroke and myocardial infarction.
TidsskriftJournal of Thrombosis and Haemostasis
Udgave nummer8
Sider (fra-til)1694-701
Antal sider8
StatusUdgivet - 1 aug. 2010

ID: 34151701