Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • John R B Perry
  • Felix Day
  • Cathy E Elks
  • Patrick Sulem
  • Deborah J Thompson
  • Teresa Ferreira
  • Chunyan He
  • Daniel I Chasman
  • Tõnu Esko
  • Gudmar Thorleifsson
  • Eva Albrecht
  • Wei Q Ang
  • Tanguy Corre
  • Diana L Cousminer
  • Bjarke Feenstra
  • Nora Franceschini
  • Andrea Ganna
  • Andrew D Johnson
  • Sanela Kjellqvist
  • Kathryn L Lunetta
  • George McMahon
  • Ilja M Nolte
  • Lavinia Paternoster
  • Eleonora Porcu
  • Albert V Smith
  • Lisette Stolk
  • Alexander Teumer
  • Natalia Tšernikova
  • Emmi Tikkanen
  • Sheila Ulivi
  • Erin K Wagner
  • Najaf Amin
  • Laura J Bierut
  • Enda M Byrne
  • Jouke-Jan Hottenga
  • Daniel L Koller
  • Massimo Mangino
  • Tune H Pers
  • Laura M Yerges-Armstrong
  • Jing Hua Zhao
  • Irene L Andrulis
  • Hoda Anton-Culver
  • Femke Atsma
  • Stefania Bandinelli
  • Matthias W Beckmann
  • Javier Benitez
  • Bojesen, Stig Egil
  • Melbye, Mads
  • Ellen A Nohr
  • Sørensen, Thorkild I.A.
  • Australian Ovarian Cancer Study

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 × 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and γ-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition.

Udgave nummer7520
Sider (fra-til)92-7
Antal sider6
StatusUdgivet - 2014

ID: 135780841