Red blood cell parameters in early childhood: a prospective cohort study
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Red blood cell parameters in early childhood : a prospective cohort study. / Nielsen, Sofie Taageby; Lytsen, Rikke Mohr; Strandkjær, Nina; Hansen, Malene Kongsgaard; Sillesen, Anne Sophie; Vøgg, Ottilia R.B.; Raja, Anna Axelsson; Rasmussen, Ida Juul; Kamstrup, Pia R.; Benn, Marianne; Iversen, Kasper; Bundgaard, Henning; Frikke-Schmidt, Ruth.
I: Clinical Chemistry and Laboratory Medicine, Bind 61, Nr. 2, 2023, s. 275-284.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Red blood cell parameters in early childhood
T2 - a prospective cohort study
AU - Nielsen, Sofie Taageby
AU - Lytsen, Rikke Mohr
AU - Strandkjær, Nina
AU - Hansen, Malene Kongsgaard
AU - Sillesen, Anne Sophie
AU - Vøgg, Ottilia R.B.
AU - Raja, Anna Axelsson
AU - Rasmussen, Ida Juul
AU - Kamstrup, Pia R.
AU - Benn, Marianne
AU - Iversen, Kasper
AU - Bundgaard, Henning
AU - Frikke-Schmidt, Ruth
N1 - Publisher Copyright: © 2023 De Gruyter. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Objectives: Red blood cell parameters are frequently used biomarkers when assessing clinical status in newborns and in early childhood. Cell counts, amounts, and concentrations of these parameters change through gestation and after birth. Robust age-specific reference intervals are needed to optimize clinical decision making. Methods: The Copenhagen Baby Heart Study (CBHS) and the COMPARE study are prospective cohort studies including red blood cell parameters from 7,938 umbilical cord blood samples and 295 parallel venous blood samples from newborns with follow-up at two and at 14–16 months after birth. Results: For venous blood at birth, reference intervals for hemoglobin, erythrocytes, and hematocrit were 145–224 g/L, 4.1–6.4 × 1012/L, and 0.44–0.64, respectively. Hemoglobin, erythrocytes, and hematocrit were lower at birth in children delivered by prelabor cesarean section compared to vaginal delivery. Conversion algorithms based on term newborns were: venous hemoglobin=(umbilical cord hemoglobin-86.4)/0.39; venous erythrocytes=(umbilical cord erythrocytes-2.20)/0.44; and venous hematocrit=(umbilical cord hematocrit-0.24)/0.45. Conclusions: This study presents new reference intervals for red blood cell parameters in early childhood, describes the impact of delivery mode, and provide exact functions for converting umbilical cord to venous blood measurements for term newborns. These findings may improve clinical decision making within neonatology and infancy and enhance our clinical understanding of red blood cell parameters for health and diseases in early life.
AB - Objectives: Red blood cell parameters are frequently used biomarkers when assessing clinical status in newborns and in early childhood. Cell counts, amounts, and concentrations of these parameters change through gestation and after birth. Robust age-specific reference intervals are needed to optimize clinical decision making. Methods: The Copenhagen Baby Heart Study (CBHS) and the COMPARE study are prospective cohort studies including red blood cell parameters from 7,938 umbilical cord blood samples and 295 parallel venous blood samples from newborns with follow-up at two and at 14–16 months after birth. Results: For venous blood at birth, reference intervals for hemoglobin, erythrocytes, and hematocrit were 145–224 g/L, 4.1–6.4 × 1012/L, and 0.44–0.64, respectively. Hemoglobin, erythrocytes, and hematocrit were lower at birth in children delivered by prelabor cesarean section compared to vaginal delivery. Conversion algorithms based on term newborns were: venous hemoglobin=(umbilical cord hemoglobin-86.4)/0.39; venous erythrocytes=(umbilical cord erythrocytes-2.20)/0.44; and venous hematocrit=(umbilical cord hematocrit-0.24)/0.45. Conclusions: This study presents new reference intervals for red blood cell parameters in early childhood, describes the impact of delivery mode, and provide exact functions for converting umbilical cord to venous blood measurements for term newborns. These findings may improve clinical decision making within neonatology and infancy and enhance our clinical understanding of red blood cell parameters for health and diseases in early life.
KW - cord blood
KW - hematology
KW - neonatology
KW - pediatrics
KW - reference intervals
U2 - 10.1515/cclm-2022-0826
DO - 10.1515/cclm-2022-0826
M3 - Journal article
C2 - 36377310
AN - SCOPUS:85142637465
VL - 61
SP - 275
EP - 284
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
SN - 1434-6621
IS - 2
ER -
ID: 334306697