TY - JOUR

T1 - Self-Reported Health as Predictor of Allostatic Load and All-Cause Mortality

T2 - Findings From the Lolland-Falster Health Study

AU - Bruun-Rasmussen, Neda Esmailzadeh

AU - Napolitano, George

AU - Bojesen, Stig Egil

AU - Ellervik, Christina

AU - Rasmussen, Knud

AU - Lynge, Elsebeth

PY - 2024

Y1 - 2024

N2 - Objectives: The aim was to determine the association between self-reported health (SRH), allostatic load (AL) and mortality.Methods: Data derived from the Lolland-Falster Health Study undertaken in Denmark from 2016–2020 (n = 14,104). Median follow-up time for death was 4.6 years where 456 participants died. SRH was assessed with a single question and AL by an index of ten biomarkers. Multinomial regression analysis were used to examine the association between SRH and AL, and Cox regression to explore the association between SRH, AL and mortality.Results: The risk of high AL increased by decreasing level of SRH. The ratio of relative risk (RRR) of having medium vs. low AL was 1.58 (1.11–2.23) in women reporting poor/very poor SRH as compared with very good SRH. For men it was 1.84 (1.20–2.81). For high vs. low AL, the RRR was 2.43 (1.66–3.56) in women and 2.96 (1.87–4.70) in men. The hazard ratio (HR) for all-cause mortality increased by decreasing SRH. For poor/very poor vs. very good SRH, the HR was 6.31 (2.84–13.99) in women and 3.92 (2.12–7.25) in men.Conclusion: Single-item SRH was able to predict risk of high AL and all-cause mortality.

AB - Objectives: The aim was to determine the association between self-reported health (SRH), allostatic load (AL) and mortality.Methods: Data derived from the Lolland-Falster Health Study undertaken in Denmark from 2016–2020 (n = 14,104). Median follow-up time for death was 4.6 years where 456 participants died. SRH was assessed with a single question and AL by an index of ten biomarkers. Multinomial regression analysis were used to examine the association between SRH and AL, and Cox regression to explore the association between SRH, AL and mortality.Results: The risk of high AL increased by decreasing level of SRH. The ratio of relative risk (RRR) of having medium vs. low AL was 1.58 (1.11–2.23) in women reporting poor/very poor SRH as compared with very good SRH. For men it was 1.84 (1.20–2.81). For high vs. low AL, the RRR was 2.43 (1.66–3.56) in women and 2.96 (1.87–4.70) in men. The hazard ratio (HR) for all-cause mortality increased by decreasing SRH. For poor/very poor vs. very good SRH, the HR was 6.31 (2.84–13.99) in women and 3.92 (2.12–7.25) in men.Conclusion: Single-item SRH was able to predict risk of high AL and all-cause mortality.

U2 - 10.3389/ijph.2024.1606585

DO - 10.3389/ijph.2024.1606585

M3 - Journal article

C2 - 38362307

VL - 69

JO - International Journal of Public Health (Print Edition)

JF - International Journal of Public Health (Print Edition)

SN - 1661-8556

M1 - 1606585

ER -