The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer

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  • Daniele Campa
  • Manuel Gentiluomo
  • Angelika Stein
  • Mateus Nóbrega Aoki
  • Martin Oliverius
  • Ludmila Vodičková
  • Krzysztof Jamroziak
  • George Theodoropoulos
  • Claudio Pasquali
  • William Greenhalf
  • Paolo Giorgio Arcidiacono
  • Faik Uzunoglu
  • Raffaele Pezzilli
  • Claudio Luchini
  • Marta Puzzono
  • Martin Loos
  • Matteo Giaccherini
  • Verena Katzke
  • Andrea Mambrini
  • Edita Kiudeliene
  • Kauffmann Emanuele Federico
  • Tamás Hussein
  • Beatrice Mohelnikova-Duchonova
  • Casper H.J. van Eijck
  • Hermann Brenner
  • Riccardo Farinella
  • Juan Sainz Pérez
  • Martin Lovecek
  • Markus W. Büchler
  • Viktor Hlavac
  • Jakob R. Izbicki
  • Thilo Hackert
  • Roger Chammas
  • Alessandro Zerbi
  • Rita Lawlor
  • Alessio Felici
  • Mara Götz
  • Gabriele Capurso
  • Laura Ginocchi
  • Maria Gazouli
  • Juozas Kupcinskas
  • Giulia Martina Cavestro
  • Pavel Vodicka
  • Stefania Moz
  • John P. Neoptolemos
  • Lumir Kunovsky
  • Silvia Carrara
  • Domenica Gioffreda
  • Egidijus Morkunas
  • Olga Abian
  • Stefania Bunduc
  • Daniela Basso
  • Ugo Boggi
  • Barbara Wlodarczyk
  • Andrea Szentesi
  • Giuseppe Vanella
  • Inna Chen
  • Maarten F. Bijlsma
  • Vytautas Kiudelis
  • Stefano Landi
  • Ben Schöttker
  • Chiara Corradi
  • Nathalia Giese
  • Rudolf Kaaks
  • Giulia Peduzzi
  • Péter Hegyi
  • Luca Morelli
  • Niccolò Furbetta
  • Pavel Soucek
  • Anna Latiano
  • Renata Talar-Wojnarowska
  • Sidsel C. Lindgaard
  • Frederike Dijk
  • Anna Caterina Milanetto
  • Francesca Tavano
  • Klara Cervena
  • Bálint Erőss
  • Sabrina G. Testoni
  • Judith H.E. Verhagen-Oldenampsen
  • Ewa Małecka-Wojciesko
  • Eithne Costello
  • Roberto Salvia
  • Evaristo Maiello
  • Stefano Ermini
  • Cosimo Sperti
  • Bernd Holleczek
  • Francesco Perri
  • Jurgita Skieceviciene
  • Livia Archibugi
  • Maurizio Lucchesi
  • Cosmeri Rizzato
  • Federico Canzian
Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.
OriginalsprogEngelsk
Artikelnummer104020
TidsskriftCritical Reviews in Oncology/Hematology
Vol/bind186
Antal sider13
ISSN1040-8428
DOI
StatusUdgivet - 2023

Bibliografisk note

Funding Information:
The research leading to these results has received funding from Associazione Italiana per la Ricerca sul Cancro (AIRC) under IG 2019—ID. 23672 project—P.I. Campa Daniele and IG 2021 ID – 26201 project P.I. Gabriele Capurso. PV, LV and KC acknowledge the support from the AZV , The Czech Ministry of Health , NU21–07–00247 and from Programme EXCELES , ID Project No. LX22NPO5102 . Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo (FG), Italy has received funding by the Italian Minister of Health , Ricerca Corrente program 2022–2024 , and by the and by the “5 × 1000″ voluntary contribution. Costello, E and Greenhalf, W are supported by grants from, Cancer Research UK ( C7690/A26881 , C18616/A25153 ) and Pancreatic Cancer UK . Sample accrual at the Amsterdam UMC was supported by the AMC Foundation . This article is based upon work from COST Action TRANSPAN, CA21116 , supported by COST (European Cooperation in Science and Technology).

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© 2023

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