Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Vitamin D and cause-specific vascular disease and mortality : a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults. / Huang, Tao; Afzal, Shoaib; Yu, Canqing; Guo, Yu; Bian, Zheng; Yang, Ling; Millwood, Iona Y.; Walters, Robin G.; Chen, Yiping; Chen, Ningyu; Gao, Ruqin; Chen, Junshi; Clarke, Robert; Chen, Zhengming; Ellervik, Christina; Nordestgaard, Børge G.; Lv, Jun; Li, Liming; Collins, Rory; Peto, Richard; Avery, Daniel; Boxall, Ruth; Bennett, Derrick; Chang, Yumei; Du, Huaidong; Gilbert, Simon; Hacker, Alex; Hill, Mike; Holmes, Michael; Iona, Andri; Kartsonaki, Christiana; Kerosi, Rene; Kong, Ling; Kurmi, Om; Lancaster, Garry; Lewington, Sarah; Lin, Kuang; McDonnell, John; Nie, Qunhua; Radhakrishnan, Jayakrishnan; Ryder, Paul; Sansome, Sam; Schmidt, Dan; Sherliker, Paul; Sohoni, Rajani; Stevens, Becky; Turnbull, Iain; Wang, Jenny; Wang, Lin; Wright, Neil; Yang, Xiaoming; Han, Xiao; Hou, Can; Pei, Pei; Liu, Chao; Tan, Yunlong; Pang, Zengchang; Li, Shanpeng; Wang, Shaojie; Liu, Yongmei; Du, Ranran; Zang, Yajing; Cheng, Liang; Tian, Xiaocao; Zhang, Hua; Zhai, Yaoming; Ning, Feng; Sun, Xiaohui; Li, Feifei; Lv, Silu; Wang, Junzheng; Hou, Wei; Zeng, Mingyuan; Jiang, Ge; Zhou, Xue; Yang, Liqiu; He, Hui; Yu, Bo; Li, Yanjie; Xu, Qinai; Kang, Quan; Guo, Ziyan; Wang, Dan; Hu, Ximin; Chen, Jinyan; Fu, Yan; Fu, Zhenwang; Wang, Xiaohuan; Weng, Min; Guo, Zhendong; Wu, Shukuan; Li, Yilei; Li, Huimei; Fu, Zhifang; Wu, Ming; Zhou, Yonglin; Zhou, Jinyi; Tao, Ran; Yang, Jie; Su, Jian; Liu, Fang; Zhang, Jun; Hu, Yihe; Lu, Yan; Ma, Liangcai; Tang, Aiyu; Zhang, Shuo; Jin, Jianrong; Liu, Jingchao; Tang, Zhenzhu; Chen, Naying; Huang, Ying; Li, Mingqiang; Meng, Jinhuai; Pan, Rong; Jiang, Qilian; Lan, Jian; Liu, Yun; Wei, Liuping; Zhou, Liyuan; Wang, Ping; Meng, Fanwen; Qin, Yulu; Wang, Sisi; Wu, Xianping; Zhang, Ningmei; Zhou, Weiwei; Luo, Guojin; Li, Jianguo; Chen, Xiaofang; Zhong, Xunfu; Liu, Jiaqiu; Sun, Qiang; Ge, Pengfei; Ren, Xiaolan; Dong, Caixia; Zhang, Hui; Mao, Enke; Wang, Xiaoping; Wang, Tao; Zhang, Xi; Zhang, Ding; Zhou, Gang; Feng, Shixian; Chang, Liang; Fan, Lei; Gao, Yulian; He, Tianyou; Sun, Huarong; Hu, Chen; Zhang, Xukui; Wu, Huifang; He, Pan; Yu, Min; Hu, Ruying; Wang, Hao; Qian, Yijian; Wang, Chunmei; Xie, Kaixu; Chen, Lingli; Zhang, Yidan; Pan, Dongxia; Gu, Qijun; Huang, Yuelong; Chen, Biyun; Yin, Li; Liu, Huilin; Fu, Zhongxi; Xu, Qiaohua; Xu, Xin; Zhang, Hao; Long, Huajun; Li, Xianzhi; Zhang, Libo; Qiu, Zhe.

I: BMC Medicine, Bind 17, 160, 08.2019.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Huang, T, Afzal, S, Yu, C, Guo, Y, Bian, Z, Yang, L, Millwood, IY, Walters, RG, Chen, Y, Chen, N, Gao, R, Chen, J, Clarke, R, Chen, Z, Ellervik, C, Nordestgaard, BG, Lv, J, Li, L, Collins, R, Peto, R, Avery, D, Boxall, R, Bennett, D, Chang, Y, Du, H, Gilbert, S, Hacker, A, Hill, M, Holmes, M, Iona, A, Kartsonaki, C, Kerosi, R, Kong, L, Kurmi, O, Lancaster, G, Lewington, S, Lin, K, McDonnell, J, Nie, Q, Radhakrishnan, J, Ryder, P, Sansome, S, Schmidt, D, Sherliker, P, Sohoni, R, Stevens, B, Turnbull, I, Wang, J, Wang, L, Wright, N, Yang, X, Han, X, Hou, C, Pei, P, Liu, C, Tan, Y, Pang, Z, Li, S, Wang, S, Liu, Y, Du, R, Zang, Y, Cheng, L, Tian, X, Zhang, H, Zhai, Y, Ning, F, Sun, X, Li, F, Lv, S, Wang, J, Hou, W, Zeng, M, Jiang, G, Zhou, X, Yang, L, He, H, Yu, B, Li, Y, Xu, Q, Kang, Q, Guo, Z, Wang, D, Hu, X, Chen, J, Fu, Y, Fu, Z, Wang, X, Weng, M, Guo, Z, Wu, S, Li, Y, Li, H, Fu, Z, Wu, M, Zhou, Y, Zhou, J, Tao, R, Yang, J, Su, J, Liu, F, Zhang, J, Hu, Y, Lu, Y, Ma, L, Tang, A, Zhang, S, Jin, J, Liu, J, Tang, Z, Chen, N, Huang, Y, Li, M, Meng, J, Pan, R, Jiang, Q, Lan, J, Liu, Y, Wei, L, Zhou, L, Wang, P, Meng, F, Qin, Y, Wang, S, Wu, X, Zhang, N, Zhou, W, Luo, G, Li, J, Chen, X, Zhong, X, Liu, J, Sun, Q, Ge, P, Ren, X, Dong, C, Zhang, H, Mao, E, Wang, X, Wang, T, Zhang, X, Zhang, D, Zhou, G, Feng, S, Chang, L, Fan, L, Gao, Y, He, T, Sun, H, Hu, C, Zhang, X, Wu, H, He, P, Yu, M, Hu, R, Wang, H, Qian, Y, Wang, C, Xie, K, Chen, L, Zhang, Y, Pan, D, Gu, Q, Huang, Y, Chen, B, Yin, L, Liu, H, Fu, Z, Xu, Q, Xu, X, Zhang, H, Long, H, Li, X, Zhang, L & Qiu, Z 2019, 'Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults', BMC Medicine, bind 17, 160. https://doi.org/10.1186/s12916-019-1401-y

APA

Huang, T., Afzal, S., Yu, C., Guo, Y., Bian, Z., Yang, L., Millwood, I. Y., Walters, R. G., Chen, Y., Chen, N., Gao, R., Chen, J., Clarke, R., Chen, Z., Ellervik, C., Nordestgaard, B. G., Lv, J., Li, L., Collins, R., ... Qiu, Z. (2019). Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults. BMC Medicine, 17, [160]. https://doi.org/10.1186/s12916-019-1401-y

Vancouver

Huang T, Afzal S, Yu C, Guo Y, Bian Z, Yang L o.a. Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults. BMC Medicine. 2019 aug.;17. 160. https://doi.org/10.1186/s12916-019-1401-y

Author

Huang, Tao ; Afzal, Shoaib ; Yu, Canqing ; Guo, Yu ; Bian, Zheng ; Yang, Ling ; Millwood, Iona Y. ; Walters, Robin G. ; Chen, Yiping ; Chen, Ningyu ; Gao, Ruqin ; Chen, Junshi ; Clarke, Robert ; Chen, Zhengming ; Ellervik, Christina ; Nordestgaard, Børge G. ; Lv, Jun ; Li, Liming ; Collins, Rory ; Peto, Richard ; Avery, Daniel ; Boxall, Ruth ; Bennett, Derrick ; Chang, Yumei ; Du, Huaidong ; Gilbert, Simon ; Hacker, Alex ; Hill, Mike ; Holmes, Michael ; Iona, Andri ; Kartsonaki, Christiana ; Kerosi, Rene ; Kong, Ling ; Kurmi, Om ; Lancaster, Garry ; Lewington, Sarah ; Lin, Kuang ; McDonnell, John ; Nie, Qunhua ; Radhakrishnan, Jayakrishnan ; Ryder, Paul ; Sansome, Sam ; Schmidt, Dan ; Sherliker, Paul ; Sohoni, Rajani ; Stevens, Becky ; Turnbull, Iain ; Wang, Jenny ; Wang, Lin ; Wright, Neil ; Yang, Xiaoming ; Han, Xiao ; Hou, Can ; Pei, Pei ; Liu, Chao ; Tan, Yunlong ; Pang, Zengchang ; Li, Shanpeng ; Wang, Shaojie ; Liu, Yongmei ; Du, Ranran ; Zang, Yajing ; Cheng, Liang ; Tian, Xiaocao ; Zhang, Hua ; Zhai, Yaoming ; Ning, Feng ; Sun, Xiaohui ; Li, Feifei ; Lv, Silu ; Wang, Junzheng ; Hou, Wei ; Zeng, Mingyuan ; Jiang, Ge ; Zhou, Xue ; Yang, Liqiu ; He, Hui ; Yu, Bo ; Li, Yanjie ; Xu, Qinai ; Kang, Quan ; Guo, Ziyan ; Wang, Dan ; Hu, Ximin ; Chen, Jinyan ; Fu, Yan ; Fu, Zhenwang ; Wang, Xiaohuan ; Weng, Min ; Guo, Zhendong ; Wu, Shukuan ; Li, Yilei ; Li, Huimei ; Fu, Zhifang ; Wu, Ming ; Zhou, Yonglin ; Zhou, Jinyi ; Tao, Ran ; Yang, Jie ; Su, Jian ; Liu, Fang ; Zhang, Jun ; Hu, Yihe ; Lu, Yan ; Ma, Liangcai ; Tang, Aiyu ; Zhang, Shuo ; Jin, Jianrong ; Liu, Jingchao ; Tang, Zhenzhu ; Chen, Naying ; Huang, Ying ; Li, Mingqiang ; Meng, Jinhuai ; Pan, Rong ; Jiang, Qilian ; Lan, Jian ; Liu, Yun ; Wei, Liuping ; Zhou, Liyuan ; Wang, Ping ; Meng, Fanwen ; Qin, Yulu ; Wang, Sisi ; Wu, Xianping ; Zhang, Ningmei ; Zhou, Weiwei ; Luo, Guojin ; Li, Jianguo ; Chen, Xiaofang ; Zhong, Xunfu ; Liu, Jiaqiu ; Sun, Qiang ; Ge, Pengfei ; Ren, Xiaolan ; Dong, Caixia ; Zhang, Hui ; Mao, Enke ; Wang, Xiaoping ; Wang, Tao ; Zhang, Xi ; Zhang, Ding ; Zhou, Gang ; Feng, Shixian ; Chang, Liang ; Fan, Lei ; Gao, Yulian ; He, Tianyou ; Sun, Huarong ; Hu, Chen ; Zhang, Xukui ; Wu, Huifang ; He, Pan ; Yu, Min ; Hu, Ruying ; Wang, Hao ; Qian, Yijian ; Wang, Chunmei ; Xie, Kaixu ; Chen, Lingli ; Zhang, Yidan ; Pan, Dongxia ; Gu, Qijun ; Huang, Yuelong ; Chen, Biyun ; Yin, Li ; Liu, Huilin ; Fu, Zhongxi ; Xu, Qiaohua ; Xu, Xin ; Zhang, Hao ; Long, Huajun ; Li, Xianzhi ; Zhang, Libo ; Qiu, Zhe. / Vitamin D and cause-specific vascular disease and mortality : a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults. I: BMC Medicine. 2019 ; Bind 17.

Bibtex

@article{fb3112795c9e43acba301afca6fb3210,
title = "Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults",
abstract = "Background: Randomised control trials and genetic analyses have demonstrated that vitamin D or 25-hydroxyvitamin D (25[OH]D) levels may not play a causal role in the development of cardiovascular disease. However, it is unclear if 25(OH)D is causally associated with cause-specific vascular disease and lipids. Therefore, we examined the causal association of 25(OH)D with myocardial infarction, stroke, ischaemic heart disease, ischaemic stroke, subarachnoid haemorrhage, intracerebral haemorrhage, and lipid levels among both Chinese and Europeans. Methods: We used a Mendelian randomisation (MR) design in the China Kadoorie Biobank, the Copenhagen City Heart Study, and the Copenhagen General Population Study. The 25(OH)D-related genetic variants in the CYP2R1 and DCHR7 genes were genotyped in 99,012 Chinese adults and 106,911 Danish adults. Results: In Chinese adults, plasma 25(OH)D levels were not significantly associated with cause-specific vascular disease or mortality, with the exception of intracerebral haemorrhage (HR, 1.09 [95% CI, 1.01,1.18] per 25 nmol/L higher plasma 25(OH)D). In Europeans, plasma 25(OH)D levels were inversely associated with all types of vascular diseases and mortality. However, MR analysis did not demonstrate causal associations of genetically increased 25(OH)D levels with cause-specific vascular diseases, or mortality in both Chinese and European adults. In addition, each 25 nmol/L higher 25(OH)D was observationally associated with lower total cholesterol and low-density lipoprotein cholesterol levels, but higher high-density lipoprotein cholesterol levels. Likewise, MR analysis showed that 25(OH)D levels were not causally associated with lipids in both Chinese and European adults after Bonferroni correction. Conclusions: We found no evidence to support that genetically increased 25(OH)D was associated with a lower risk of ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and lipid levels in both Chinese and European adults. These results suggest that the inverse associations of vitamin D with vascular disease could be the result of confounding.",
keywords = "Cardiovascular diseases, Causal effect, Lipids, Mendelian randomisation, Vitamin D",
author = "Tao Huang and Shoaib Afzal and Canqing Yu and Yu Guo and Zheng Bian and Ling Yang and Millwood, {Iona Y.} and Walters, {Robin G.} and Yiping Chen and Ningyu Chen and Ruqin Gao and Junshi Chen and Robert Clarke and Zhengming Chen and Christina Ellervik and Nordestgaard, {B{\o}rge G.} and Jun Lv and Liming Li and Rory Collins and Richard Peto and Daniel Avery and Ruth Boxall and Derrick Bennett and Yumei Chang and Huaidong Du and Simon Gilbert and Alex Hacker and Mike Hill and Michael Holmes and Andri Iona and Christiana Kartsonaki and Rene Kerosi and Ling Kong and Om Kurmi and Garry Lancaster and Sarah Lewington and Kuang Lin and John McDonnell and Qunhua Nie and Jayakrishnan Radhakrishnan and Paul Ryder and Sam Sansome and Dan Schmidt and Paul Sherliker and Rajani Sohoni and Becky Stevens and Iain Turnbull and Jenny Wang and Lin Wang and Neil Wright and Xiaoming Yang and Xiao Han and Can Hou and Pei Pei and Chao Liu and Yunlong Tan and Zengchang Pang and Shanpeng Li and Shaojie Wang and Yongmei Liu and Ranran Du and Yajing Zang and Liang Cheng and Xiaocao Tian and Hua Zhang and Yaoming Zhai and Feng Ning and Xiaohui Sun and Feifei Li and Silu Lv and Junzheng Wang and Wei Hou and Mingyuan Zeng and Ge Jiang and Xue Zhou and Liqiu Yang and Hui He and Bo Yu and Yanjie Li and Qinai Xu and Quan Kang and Ziyan Guo and Dan Wang and Ximin Hu and Jinyan Chen and Yan Fu and Zhenwang Fu and Xiaohuan Wang and Min Weng and Zhendong Guo and Shukuan Wu and Yilei Li and Huimei Li and Zhifang Fu and Ming Wu and Yonglin Zhou and Jinyi Zhou and Ran Tao and Jie Yang and Jian Su and Fang Liu and Jun Zhang and Yihe Hu and Yan Lu and Liangcai Ma and Aiyu Tang and Shuo Zhang and Jianrong Jin and Jingchao Liu and Zhenzhu Tang and Naying Chen and Ying Huang and Mingqiang Li and Jinhuai Meng and Rong Pan and Qilian Jiang and Jian Lan and Yun Liu and Liuping Wei and Liyuan Zhou and Ping Wang and Fanwen Meng and Yulu Qin and Sisi Wang and Xianping Wu and Ningmei Zhang and Weiwei Zhou and Guojin Luo and Jianguo Li and Xiaofang Chen and Xunfu Zhong and Jiaqiu Liu and Qiang Sun and Pengfei Ge and Xiaolan Ren and Caixia Dong and Hui Zhang and Enke Mao and Xiaoping Wang and Tao Wang and Xi Zhang and Ding Zhang and Gang Zhou and Shixian Feng and Liang Chang and Lei Fan and Yulian Gao and Tianyou He and Huarong Sun and Chen Hu and Xukui Zhang and Huifang Wu and Pan He and Min Yu and Ruying Hu and Hao Wang and Yijian Qian and Chunmei Wang and Kaixu Xie and Lingli Chen and Yidan Zhang and Dongxia Pan and Qijun Gu and Yuelong Huang and Biyun Chen and Li Yin and Huilin Liu and Zhongxi Fu and Qiaohua Xu and Xin Xu and Hao Zhang and Huajun Long and Xianzhi Li and Libo Zhang and Zhe Qiu",
year = "2019",
month = aug,
doi = "10.1186/s12916-019-1401-y",
language = "English",
volume = "17",
journal = "BMC Medicine",
issn = "1741-7015",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Vitamin D and cause-specific vascular disease and mortality

T2 - a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults

AU - Huang, Tao

AU - Afzal, Shoaib

AU - Yu, Canqing

AU - Guo, Yu

AU - Bian, Zheng

AU - Yang, Ling

AU - Millwood, Iona Y.

AU - Walters, Robin G.

AU - Chen, Yiping

AU - Chen, Ningyu

AU - Gao, Ruqin

AU - Chen, Junshi

AU - Clarke, Robert

AU - Chen, Zhengming

AU - Ellervik, Christina

AU - Nordestgaard, Børge G.

AU - Lv, Jun

AU - Li, Liming

AU - Collins, Rory

AU - Peto, Richard

AU - Avery, Daniel

AU - Boxall, Ruth

AU - Bennett, Derrick

AU - Chang, Yumei

AU - Du, Huaidong

AU - Gilbert, Simon

AU - Hacker, Alex

AU - Hill, Mike

AU - Holmes, Michael

AU - Iona, Andri

AU - Kartsonaki, Christiana

AU - Kerosi, Rene

AU - Kong, Ling

AU - Kurmi, Om

AU - Lancaster, Garry

AU - Lewington, Sarah

AU - Lin, Kuang

AU - McDonnell, John

AU - Nie, Qunhua

AU - Radhakrishnan, Jayakrishnan

AU - Ryder, Paul

AU - Sansome, Sam

AU - Schmidt, Dan

AU - Sherliker, Paul

AU - Sohoni, Rajani

AU - Stevens, Becky

AU - Turnbull, Iain

AU - Wang, Jenny

AU - Wang, Lin

AU - Wright, Neil

AU - Yang, Xiaoming

AU - Han, Xiao

AU - Hou, Can

AU - Pei, Pei

AU - Liu, Chao

AU - Tan, Yunlong

AU - Pang, Zengchang

AU - Li, Shanpeng

AU - Wang, Shaojie

AU - Liu, Yongmei

AU - Du, Ranran

AU - Zang, Yajing

AU - Cheng, Liang

AU - Tian, Xiaocao

AU - Zhang, Hua

AU - Zhai, Yaoming

AU - Ning, Feng

AU - Sun, Xiaohui

AU - Li, Feifei

AU - Lv, Silu

AU - Wang, Junzheng

AU - Hou, Wei

AU - Zeng, Mingyuan

AU - Jiang, Ge

AU - Zhou, Xue

AU - Yang, Liqiu

AU - He, Hui

AU - Yu, Bo

AU - Li, Yanjie

AU - Xu, Qinai

AU - Kang, Quan

AU - Guo, Ziyan

AU - Wang, Dan

AU - Hu, Ximin

AU - Chen, Jinyan

AU - Fu, Yan

AU - Fu, Zhenwang

AU - Wang, Xiaohuan

AU - Weng, Min

AU - Guo, Zhendong

AU - Wu, Shukuan

AU - Li, Yilei

AU - Li, Huimei

AU - Fu, Zhifang

AU - Wu, Ming

AU - Zhou, Yonglin

AU - Zhou, Jinyi

AU - Tao, Ran

AU - Yang, Jie

AU - Su, Jian

AU - Liu, Fang

AU - Zhang, Jun

AU - Hu, Yihe

AU - Lu, Yan

AU - Ma, Liangcai

AU - Tang, Aiyu

AU - Zhang, Shuo

AU - Jin, Jianrong

AU - Liu, Jingchao

AU - Tang, Zhenzhu

AU - Chen, Naying

AU - Huang, Ying

AU - Li, Mingqiang

AU - Meng, Jinhuai

AU - Pan, Rong

AU - Jiang, Qilian

AU - Lan, Jian

AU - Liu, Yun

AU - Wei, Liuping

AU - Zhou, Liyuan

AU - Wang, Ping

AU - Meng, Fanwen

AU - Qin, Yulu

AU - Wang, Sisi

AU - Wu, Xianping

AU - Zhang, Ningmei

AU - Zhou, Weiwei

AU - Luo, Guojin

AU - Li, Jianguo

AU - Chen, Xiaofang

AU - Zhong, Xunfu

AU - Liu, Jiaqiu

AU - Sun, Qiang

AU - Ge, Pengfei

AU - Ren, Xiaolan

AU - Dong, Caixia

AU - Zhang, Hui

AU - Mao, Enke

AU - Wang, Xiaoping

AU - Wang, Tao

AU - Zhang, Xi

AU - Zhang, Ding

AU - Zhou, Gang

AU - Feng, Shixian

AU - Chang, Liang

AU - Fan, Lei

AU - Gao, Yulian

AU - He, Tianyou

AU - Sun, Huarong

AU - Hu, Chen

AU - Zhang, Xukui

AU - Wu, Huifang

AU - He, Pan

AU - Yu, Min

AU - Hu, Ruying

AU - Wang, Hao

AU - Qian, Yijian

AU - Wang, Chunmei

AU - Xie, Kaixu

AU - Chen, Lingli

AU - Zhang, Yidan

AU - Pan, Dongxia

AU - Gu, Qijun

AU - Huang, Yuelong

AU - Chen, Biyun

AU - Yin, Li

AU - Liu, Huilin

AU - Fu, Zhongxi

AU - Xu, Qiaohua

AU - Xu, Xin

AU - Zhang, Hao

AU - Long, Huajun

AU - Li, Xianzhi

AU - Zhang, Libo

AU - Qiu, Zhe

PY - 2019/8

Y1 - 2019/8

N2 - Background: Randomised control trials and genetic analyses have demonstrated that vitamin D or 25-hydroxyvitamin D (25[OH]D) levels may not play a causal role in the development of cardiovascular disease. However, it is unclear if 25(OH)D is causally associated with cause-specific vascular disease and lipids. Therefore, we examined the causal association of 25(OH)D with myocardial infarction, stroke, ischaemic heart disease, ischaemic stroke, subarachnoid haemorrhage, intracerebral haemorrhage, and lipid levels among both Chinese and Europeans. Methods: We used a Mendelian randomisation (MR) design in the China Kadoorie Biobank, the Copenhagen City Heart Study, and the Copenhagen General Population Study. The 25(OH)D-related genetic variants in the CYP2R1 and DCHR7 genes were genotyped in 99,012 Chinese adults and 106,911 Danish adults. Results: In Chinese adults, plasma 25(OH)D levels were not significantly associated with cause-specific vascular disease or mortality, with the exception of intracerebral haemorrhage (HR, 1.09 [95% CI, 1.01,1.18] per 25 nmol/L higher plasma 25(OH)D). In Europeans, plasma 25(OH)D levels were inversely associated with all types of vascular diseases and mortality. However, MR analysis did not demonstrate causal associations of genetically increased 25(OH)D levels with cause-specific vascular diseases, or mortality in both Chinese and European adults. In addition, each 25 nmol/L higher 25(OH)D was observationally associated with lower total cholesterol and low-density lipoprotein cholesterol levels, but higher high-density lipoprotein cholesterol levels. Likewise, MR analysis showed that 25(OH)D levels were not causally associated with lipids in both Chinese and European adults after Bonferroni correction. Conclusions: We found no evidence to support that genetically increased 25(OH)D was associated with a lower risk of ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and lipid levels in both Chinese and European adults. These results suggest that the inverse associations of vitamin D with vascular disease could be the result of confounding.

AB - Background: Randomised control trials and genetic analyses have demonstrated that vitamin D or 25-hydroxyvitamin D (25[OH]D) levels may not play a causal role in the development of cardiovascular disease. However, it is unclear if 25(OH)D is causally associated with cause-specific vascular disease and lipids. Therefore, we examined the causal association of 25(OH)D with myocardial infarction, stroke, ischaemic heart disease, ischaemic stroke, subarachnoid haemorrhage, intracerebral haemorrhage, and lipid levels among both Chinese and Europeans. Methods: We used a Mendelian randomisation (MR) design in the China Kadoorie Biobank, the Copenhagen City Heart Study, and the Copenhagen General Population Study. The 25(OH)D-related genetic variants in the CYP2R1 and DCHR7 genes were genotyped in 99,012 Chinese adults and 106,911 Danish adults. Results: In Chinese adults, plasma 25(OH)D levels were not significantly associated with cause-specific vascular disease or mortality, with the exception of intracerebral haemorrhage (HR, 1.09 [95% CI, 1.01,1.18] per 25 nmol/L higher plasma 25(OH)D). In Europeans, plasma 25(OH)D levels were inversely associated with all types of vascular diseases and mortality. However, MR analysis did not demonstrate causal associations of genetically increased 25(OH)D levels with cause-specific vascular diseases, or mortality in both Chinese and European adults. In addition, each 25 nmol/L higher 25(OH)D was observationally associated with lower total cholesterol and low-density lipoprotein cholesterol levels, but higher high-density lipoprotein cholesterol levels. Likewise, MR analysis showed that 25(OH)D levels were not causally associated with lipids in both Chinese and European adults after Bonferroni correction. Conclusions: We found no evidence to support that genetically increased 25(OH)D was associated with a lower risk of ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and lipid levels in both Chinese and European adults. These results suggest that the inverse associations of vitamin D with vascular disease could be the result of confounding.

KW - Cardiovascular diseases

KW - Causal effect

KW - Lipids

KW - Mendelian randomisation

KW - Vitamin D

U2 - 10.1186/s12916-019-1401-y

DO - 10.1186/s12916-019-1401-y

M3 - Journal article

C2 - 31466528

AN - SCOPUS:85071610534

VL - 17

JO - BMC Medicine

JF - BMC Medicine

SN - 1741-7015

M1 - 160

ER -

ID: 241215020