The role of the glutathione S-transferase genes GSTT1, GSTM1, and GSTP1 in acetaminophen-poisoned patients
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The role of the glutathione S-transferase genes GSTT1, GSTM1, and GSTP1 in acetaminophen-poisoned patients. / Buchard, Anders; Eefsen, Martin; Semb, Synne; Andersen, Stig Ejdrup; Morling, Niels; Bendtsen, Flemming; Larsen, Fin Stolze; Dalhoff, Kim.
I: Clinical toxicology (Philadelphia, Pa.), Bind 50, Nr. 1, 2012, s. 27-33.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - The role of the glutathione S-transferase genes GSTT1, GSTM1, and GSTP1 in acetaminophen-poisoned patients
AU - Buchard, Anders
AU - Eefsen, Martin
AU - Semb, Synne
AU - Andersen, Stig Ejdrup
AU - Morling, Niels
AU - Bendtsen, Flemming
AU - Larsen, Fin Stolze
AU - Dalhoff, Kim
PY - 2012
Y1 - 2012
N2 - The aim of this study was to assess if genetic variants in the glutathione-S-transferase genes GST-T1, M1, and P1 reflect risk factors in acetaminophen (APAP)-poisoned patients assessed by investigation of the relation to prothrombin time (PT), which is a sensitive marker of survival in these patients. A total of 104 APAP-poisoned patients were genotyped for deletion polymorphisms in the GSTT1 and GSTM1 genes and for the GSTP1 Ile105Val polymorphism. We found a borderline association (p = 0.05) between the GSTT1 homozygous deletion genotype and high trough PT (a marker of prognosis in APAP poisoning) compared to carrying two functioning copies of the gene. No significant association was found between any of the GSTM1 and GSTP1 genotypes and PT. The frequency of GSTP1 Val/Val genotypes was significantly lower in the patients than in the background population (p = 0.047). The results suggest that the GSTT1 homozygous deletion genotype may be associated with a better prognosis after APAP poisoning and that carriers of the GSTP1 homozygous variant genotype may have a decreased risk of being APAP poisoned.
AB - The aim of this study was to assess if genetic variants in the glutathione-S-transferase genes GST-T1, M1, and P1 reflect risk factors in acetaminophen (APAP)-poisoned patients assessed by investigation of the relation to prothrombin time (PT), which is a sensitive marker of survival in these patients. A total of 104 APAP-poisoned patients were genotyped for deletion polymorphisms in the GSTT1 and GSTM1 genes and for the GSTP1 Ile105Val polymorphism. We found a borderline association (p = 0.05) between the GSTT1 homozygous deletion genotype and high trough PT (a marker of prognosis in APAP poisoning) compared to carrying two functioning copies of the gene. No significant association was found between any of the GSTM1 and GSTP1 genotypes and PT. The frequency of GSTP1 Val/Val genotypes was significantly lower in the patients than in the background population (p = 0.047). The results suggest that the GSTT1 homozygous deletion genotype may be associated with a better prognosis after APAP poisoning and that carriers of the GSTP1 homozygous variant genotype may have a decreased risk of being APAP poisoned.
KW - Acetaminophen
KW - Adult
KW - Female
KW - Gene Deletion
KW - Genes
KW - Genotype
KW - Glutathione S-Transferase pi
KW - Glutathione Transferase
KW - Homozygote
KW - Humans
KW - Male
KW - Middle Aged
KW - Overdose
KW - Polymorphism, Genetic
KW - Prothrombin Time
KW - Risk Factors
U2 - 10.3109/15563650.2011.639713
DO - 10.3109/15563650.2011.639713
M3 - Journal article
C2 - 22175791
VL - 50
SP - 27
EP - 33
JO - Clinical Toxicology
JF - Clinical Toxicology
SN - 1556-3650
IS - 1
ER -
ID: 38258287