Assessment of muscle function using hybrid PET/MRI: comparison of 18F-FDG PET and T2-weighted MRI for quantifying muscle activation in human subjects
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Assessment of muscle function using hybrid PET/MRI : comparison of 18F-FDG PET and T2-weighted MRI for quantifying muscle activation in human subjects. / Haddock, Bryan; Holm, Søren; Poulsen, Jákup M.; Enevoldsen, Lotte H.; Larsson, Henrik B.W.; Kjær, Andreas; Suetta, Charlotte.
I: European Journal of Nuclear Medicine and Molecular Imaging, Bind 44, Nr. 4, 2017, s. 704-711.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Assessment of muscle function using hybrid PET/MRI
T2 - comparison of 18F-FDG PET and T2-weighted MRI for quantifying muscle activation in human subjects
AU - Haddock, Bryan
AU - Holm, Søren
AU - Poulsen, Jákup M.
AU - Enevoldsen, Lotte H.
AU - Larsson, Henrik B.W.
AU - Kjær, Andreas
AU - Suetta, Charlotte
PY - 2017
Y1 - 2017
N2 - Purpose: The aim of this study was to determine the relationship between relative glucose uptake and MRI T2 changes in skeletal muscles following resistance exercise using simultaneous PET/MRI scans. Methods: Ten young healthy recreationally active men (age 21 – 28 years) were injected with 18F-FDG while activating the quadriceps of one leg with repeated knee extension exercises followed by hand-grip exercises for one arm. Immediately following the exercises, the subjects were scanned simultaneously with 18F-FDG PET/MRI and muscle groups were evaluated for increases in 18F-FDG uptake and MRI T2 values. Results: A significant linear correlation between 18F-FDG uptake and changes in muscle T2 (R2 = 0.71) was found. for both small and large muscles and in voxel to voxel comparisons. Despite large intersubject differences in muscle recruitment, the linear correlation between 18F-FDG uptake and changes in muscle T2 did not vary among subjects. Conclusion: This is the first assessment of skeletal muscle activation using hybrid PET/MRI and the first study to demonstrate a high correlation between 18F-FDG uptake and changes in muscle T2 with physical exercise. Accordingly, it seems that changes in muscle T2 may be used as a surrogate marker for glucose uptake and lead to an improved insight into the metabolic changes that occur with muscle activation. Such knowledge may lead to improved treatment strategies in patients with neuromuscular pathologies such as stroke, spinal cord injuries and muscular dystrophies.
AB - Purpose: The aim of this study was to determine the relationship between relative glucose uptake and MRI T2 changes in skeletal muscles following resistance exercise using simultaneous PET/MRI scans. Methods: Ten young healthy recreationally active men (age 21 – 28 years) were injected with 18F-FDG while activating the quadriceps of one leg with repeated knee extension exercises followed by hand-grip exercises for one arm. Immediately following the exercises, the subjects were scanned simultaneously with 18F-FDG PET/MRI and muscle groups were evaluated for increases in 18F-FDG uptake and MRI T2 values. Results: A significant linear correlation between 18F-FDG uptake and changes in muscle T2 (R2 = 0.71) was found. for both small and large muscles and in voxel to voxel comparisons. Despite large intersubject differences in muscle recruitment, the linear correlation between 18F-FDG uptake and changes in muscle T2 did not vary among subjects. Conclusion: This is the first assessment of skeletal muscle activation using hybrid PET/MRI and the first study to demonstrate a high correlation between 18F-FDG uptake and changes in muscle T2 with physical exercise. Accordingly, it seems that changes in muscle T2 may be used as a surrogate marker for glucose uptake and lead to an improved insight into the metabolic changes that occur with muscle activation. Such knowledge may lead to improved treatment strategies in patients with neuromuscular pathologies such as stroke, spinal cord injuries and muscular dystrophies.
KW - Exercise
KW - Hybrid imaging
KW - Muscle
KW - PET/MRI
KW - T
U2 - 10.1007/s00259-016-3507-1
DO - 10.1007/s00259-016-3507-1
M3 - Journal article
C2 - 27604791
AN - SCOPUS:84986277765
VL - 44
SP - 704
EP - 711
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
SN - 1619-7070
IS - 4
ER -
ID: 189862242