Kinetic [18F]-Fluoride of the Knee in Normal Volunteers
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Kinetic [18F]-Fluoride of the Knee in Normal Volunteers. / Haddock, Bryan; Fan, Audrey P; Jørgensen, Niklas R; Suetta, Charlotte; Gold, Garry Evan; Kogan, Feliks.
I: Clinical Nuclear Medicine, Bind 44, Nr. 5, 2019, s. 377-385.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Kinetic [18F]-Fluoride of the Knee in Normal Volunteers
AU - Haddock, Bryan
AU - Fan, Audrey P
AU - Jørgensen, Niklas R
AU - Suetta, Charlotte
AU - Gold, Garry Evan
AU - Kogan, Feliks
PY - 2019
Y1 - 2019
N2 - PURPOSE: [F]-sodium fluoride ([F]NaF) is a well-established bone-seeking agent that has shown promise to assess bone turnover in a variety of disorders, but its distribution in healthy knee joints has not been explored. This study aimed to investigate parametric values for [F]NaF uptake in various bone tissues types of the knee and their spatial distributions.METHODS: Twelve healthy subjects were hand-injected with 92.5 MBq of [F]NaF and scanned on a 3-T PET/MRI system. Listmode PET data for both knees were acquired for 50 minutes from injection simultaneously with MRI Dixon and angiography data. The image-derived input function was determined from the popliteal artery. Using the Hawkins model, Patlak analysis was performed to obtain Ki (Ki) values and nonlinear regression analysis to obtain Ki, K1, k3/(k2 + k3), and blood volume. Comparisons for the measured kinetic parameters, SUV, and SUVmax were made between tissue types (subchondral, cortical, and trabecular bone) and between regional subsections of subchondral bone.RESULTS: Cortical bone had the highest [F]NaF uptake differing significantly in all measured parameters when compared with trabecular bone and significantly higher SUVmax and K1 than subchondral bone. Subchondral bone also had significantly higher SUV, SUVmax, and Ki than trabecular bone tissue. Regional differences were observed in K1 and k3/(k2 + k3) values.CONCLUSIONS: Quantitative [F]NaF PET is sensitive to variations in bone vascularization and metabolism in the knee joint.
AB - PURPOSE: [F]-sodium fluoride ([F]NaF) is a well-established bone-seeking agent that has shown promise to assess bone turnover in a variety of disorders, but its distribution in healthy knee joints has not been explored. This study aimed to investigate parametric values for [F]NaF uptake in various bone tissues types of the knee and their spatial distributions.METHODS: Twelve healthy subjects were hand-injected with 92.5 MBq of [F]NaF and scanned on a 3-T PET/MRI system. Listmode PET data for both knees were acquired for 50 minutes from injection simultaneously with MRI Dixon and angiography data. The image-derived input function was determined from the popliteal artery. Using the Hawkins model, Patlak analysis was performed to obtain Ki (Ki) values and nonlinear regression analysis to obtain Ki, K1, k3/(k2 + k3), and blood volume. Comparisons for the measured kinetic parameters, SUV, and SUVmax were made between tissue types (subchondral, cortical, and trabecular bone) and between regional subsections of subchondral bone.RESULTS: Cortical bone had the highest [F]NaF uptake differing significantly in all measured parameters when compared with trabecular bone and significantly higher SUVmax and K1 than subchondral bone. Subchondral bone also had significantly higher SUV, SUVmax, and Ki than trabecular bone tissue. Regional differences were observed in K1 and k3/(k2 + k3) values.CONCLUSIONS: Quantitative [F]NaF PET is sensitive to variations in bone vascularization and metabolism in the knee joint.
KW - Adult
KW - Female
KW - Fluorides/pharmacokinetics
KW - Healthy Volunteers
KW - Humans
KW - Knee/diagnostic imaging
KW - Magnetic Resonance Imaging
KW - Male
KW - Multimodal Imaging
KW - Positron-Emission Tomography/methods
KW - Radiopharmaceuticals/pharmacokinetics
KW - Reproducibility of Results
U2 - 10.1097/RLU.0000000000002533
DO - 10.1097/RLU.0000000000002533
M3 - Journal article
C2 - 30888996
VL - 44
SP - 377
EP - 385
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
SN - 0363-9762
IS - 5
ER -
ID: 237850143