An explorative metabolomic analysis of the endothelium in pulmonary hypertension

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An explorative metabolomic analysis of the endothelium in pulmonary hypertension. / Carlsen, J.; Henriksen, H. H.; Marin de Mas, I.; Johansson, P. I.

I: Scientific Reports, Bind 12, 13284, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Carlsen, J, Henriksen, HH, Marin de Mas, I & Johansson, PI 2022, 'An explorative metabolomic analysis of the endothelium in pulmonary hypertension', Scientific Reports, bind 12, 13284. https://doi.org/10.1038/s41598-022-17374-x

APA

Carlsen, J., Henriksen, H. H., Marin de Mas, I., & Johansson, P. I. (2022). An explorative metabolomic analysis of the endothelium in pulmonary hypertension. Scientific Reports, 12, [13284]. https://doi.org/10.1038/s41598-022-17374-x

Vancouver

Carlsen J, Henriksen HH, Marin de Mas I, Johansson PI. An explorative metabolomic analysis of the endothelium in pulmonary hypertension. Scientific Reports. 2022;12. 13284. https://doi.org/10.1038/s41598-022-17374-x

Author

Carlsen, J. ; Henriksen, H. H. ; Marin de Mas, I. ; Johansson, P. I. / An explorative metabolomic analysis of the endothelium in pulmonary hypertension. I: Scientific Reports. 2022 ; Bind 12.

Bibtex

@article{cbcf6e7b4d3449789738f39091342b8d,

title = "An explorative metabolomic analysis of the endothelium in pulmonary hypertension",

abstract = "Pulmonary hypertension (PH) is classified into five clinical diagnostic groups, including group 1 [idiopathic pulmonary arterial hypertension (IPAH) and connective tissue disease-associated PAH (CTD-aPAH)] and group 4 (chronic thromboembolic pulmonary hypertension (CTEPH)). PH is a progressive, life-threatening, incurable disease. The pathological mechanisms underlying PH remain elusive; recent evidence has revealed that abnormal metabolic activities in the endothelium may play a crucial role. This research introduces a novel approach for studying PH endothelial function, building on the genome-scale metabolic reconstruction of the endothelial cell (EC) to investigate intracellular metabolism. We demonstrate that the intracellular metabolic activities of ECs in PH patients cluster into four phenotypes independent of the PH diagnosis. Notably, the disease severity differs significantly between the metabolic phenotypes, suggesting their clinical relevance. The significant metabolic differences between the PH phenotypes indicate that they may require different therapeutic interventions. In addition, diagnostic capabilities enabling their identification is warranted to investigate whether this opens a novel avenue of precision medicine.",

author = "J. Carlsen and Henriksen, {H. H.} and {Marin de Mas}, I. and Johansson, {P. I.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

doi = "10.1038/s41598-022-17374-x",

language = "English",

volume = "12",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - An explorative metabolomic analysis of the endothelium in pulmonary hypertension

AU - Carlsen, J.

AU - Henriksen, H. H.

AU - Marin de Mas, I.

AU - Johansson, P. I.

PY - 2022

Y1 - 2022

N2 - Pulmonary hypertension (PH) is classified into five clinical diagnostic groups, including group 1 [idiopathic pulmonary arterial hypertension (IPAH) and connective tissue disease-associated PAH (CTD-aPAH)] and group 4 (chronic thromboembolic pulmonary hypertension (CTEPH)). PH is a progressive, life-threatening, incurable disease. The pathological mechanisms underlying PH remain elusive; recent evidence has revealed that abnormal metabolic activities in the endothelium may play a crucial role. This research introduces a novel approach for studying PH endothelial function, building on the genome-scale metabolic reconstruction of the endothelial cell (EC) to investigate intracellular metabolism. We demonstrate that the intracellular metabolic activities of ECs in PH patients cluster into four phenotypes independent of the PH diagnosis. Notably, the disease severity differs significantly between the metabolic phenotypes, suggesting their clinical relevance. The significant metabolic differences between the PH phenotypes indicate that they may require different therapeutic interventions. In addition, diagnostic capabilities enabling their identification is warranted to investigate whether this opens a novel avenue of precision medicine.

AB - Pulmonary hypertension (PH) is classified into five clinical diagnostic groups, including group 1 [idiopathic pulmonary arterial hypertension (IPAH) and connective tissue disease-associated PAH (CTD-aPAH)] and group 4 (chronic thromboembolic pulmonary hypertension (CTEPH)). PH is a progressive, life-threatening, incurable disease. The pathological mechanisms underlying PH remain elusive; recent evidence has revealed that abnormal metabolic activities in the endothelium may play a crucial role. This research introduces a novel approach for studying PH endothelial function, building on the genome-scale metabolic reconstruction of the endothelial cell (EC) to investigate intracellular metabolism. We demonstrate that the intracellular metabolic activities of ECs in PH patients cluster into four phenotypes independent of the PH diagnosis. Notably, the disease severity differs significantly between the metabolic phenotypes, suggesting their clinical relevance. The significant metabolic differences between the PH phenotypes indicate that they may require different therapeutic interventions. In addition, diagnostic capabilities enabling their identification is warranted to investigate whether this opens a novel avenue of precision medicine.

U2 - 10.1038/s41598-022-17374-x

DO - 10.1038/s41598-022-17374-x

M3 - Journal article

C2 - 35918401

AN - SCOPUS:85135231467

VL - 12

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 13284

ER -

ID: 331255831

Institut for Klinisk Medicin