Incidence of infective endocarditis in patients considered at moderate risk

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Standard

Incidence of infective endocarditis in patients considered at moderate risk. / Østergaard, Lauge; Valeur, Nana; Wang, Andrew; Bundgaard, Henning; Aslam, Mohsin; Gislason, Gunnar; Torp-Pedersen, Christian; Bruun, Niels Eske; Søndergaard, Lars; Køber, Lars; Fosbøl, Emil Loldrup.

I: European Heart Journal, Bind 40, Nr. 17, 01.05.2019, s. 1355-1361.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Østergaard, L, Valeur, N, Wang, A, Bundgaard, H, Aslam, M, Gislason, G, Torp-Pedersen, C, Bruun, NE, Søndergaard, L, Køber, L & Fosbøl, EL 2019, 'Incidence of infective endocarditis in patients considered at moderate risk', European Heart Journal, bind 40, nr. 17, s. 1355-1361. https://doi.org/10.1093/eurheartj/ehy629

APA

Østergaard, L., Valeur, N., Wang, A., Bundgaard, H., Aslam, M., Gislason, G., Torp-Pedersen, C., Bruun, N. E., Søndergaard, L., Køber, L., & Fosbøl, E. L. (2019). Incidence of infective endocarditis in patients considered at moderate risk. European Heart Journal, 40(17), 1355-1361. https://doi.org/10.1093/eurheartj/ehy629

Vancouver

Østergaard L, Valeur N, Wang A, Bundgaard H, Aslam M, Gislason G o.a. Incidence of infective endocarditis in patients considered at moderate risk. European Heart Journal. 2019 maj 1;40(17):1355-1361. https://doi.org/10.1093/eurheartj/ehy629

Author

Østergaard, Lauge ; Valeur, Nana ; Wang, Andrew ; Bundgaard, Henning ; Aslam, Mohsin ; Gislason, Gunnar ; Torp-Pedersen, Christian ; Bruun, Niels Eske ; Søndergaard, Lars ; Køber, Lars ; Fosbøl, Emil Loldrup. / Incidence of infective endocarditis in patients considered at moderate risk. I: European Heart Journal. 2019 ; Bind 40, Nr. 17. s. 1355-1361.

Bibtex

@article{ab161ee96492474887d5869d65a3b4d0,

title = "Incidence of infective endocarditis in patients considered at moderate risk",

abstract = "AIMS: Stratification of patients at risk of infective endocarditis (IE) remains a cornerstone in guidance of prophylactic strategies of IE. However, little attention has been given to patients considered at moderate risk.METHODS AND RESULTS: Using Danish nationwide registries, we assessed the risk of IE in patients with aortic and mitral valve disorders, a cardiac implantable electronic device (CIED), or hypertrophic cardiomyopathy (HCM) and compared these patient groups with (i) controls from the background population using risk-set matching and (ii) a high-risk population (prosthetic heart valve). Cumulative incidence plots and multivariable adjusted Cox proportional hazard analysis were used to compare risk of IE between risk groups. We identified 83 453 patients with aortic or mitral valve disorder, 50 828 with a CIED, and 3620 with HCM. The cumulative risk of IE after 10 years was 0.9% in valve disorder, 1.3% in CIED, and 0.5% in HCM patients. Compared with the background population, valve disorder, CIED, and HCM carried a higher associated risk of IE, hazard ratio (HR) = 8.75 [95% confidence interval (CI) 6.36-12.02], HR = 6.63 (95% CI 4.41-9.96), and HR = 6.57 (95% CI 2.33-18.56), respectively. All three study groups were associated with a lower risk of IE compared with high-risk patients, HR = 0.27 (95% CI 0.23-0.32) for valve disorder, HR = 0.28 (95% CI 0.23-0.33) for CIED, and HR = 0.13 (95% CI 0.06-0.29) for HCM.CONCLUSIONS: Heart valve disorder, CIED, and patients with HCM were associated with a higher risk of IE compared with the background population but have a lower associated risk of IE compared with high-risk patients.",

author = "Lauge {\O}stergaard and Nana Valeur and Andrew Wang and Henning Bundgaard and Mohsin Aslam and Gunnar Gislason and Christian Torp-Pedersen and Bruun, {Niels Eske} and Lars S{\o}ndergaard and Lars K{\o}ber and Fosb{\o}l, {Emil Loldrup}",

year = "2019",

month = may,

day = "1",

doi = "10.1093/eurheartj/ehy629",

language = "English",

volume = "40",

pages = "1355--1361",

journal = "European Heart Journal",

issn = "0195-668X",

publisher = "Oxford University Press",

number = "17",

}

RIS

TY - JOUR

T1 - Incidence of infective endocarditis in patients considered at moderate risk

AU - Østergaard, Lauge

AU - Valeur, Nana

AU - Wang, Andrew

AU - Bundgaard, Henning

AU - Aslam, Mohsin

AU - Gislason, Gunnar

AU - Torp-Pedersen, Christian

AU - Bruun, Niels Eske

AU - Søndergaard, Lars

AU - Køber, Lars

AU - Fosbøl, Emil Loldrup

PY - 2019/5/1

Y1 - 2019/5/1

N2 - AIMS: Stratification of patients at risk of infective endocarditis (IE) remains a cornerstone in guidance of prophylactic strategies of IE. However, little attention has been given to patients considered at moderate risk.METHODS AND RESULTS: Using Danish nationwide registries, we assessed the risk of IE in patients with aortic and mitral valve disorders, a cardiac implantable electronic device (CIED), or hypertrophic cardiomyopathy (HCM) and compared these patient groups with (i) controls from the background population using risk-set matching and (ii) a high-risk population (prosthetic heart valve). Cumulative incidence plots and multivariable adjusted Cox proportional hazard analysis were used to compare risk of IE between risk groups. We identified 83 453 patients with aortic or mitral valve disorder, 50 828 with a CIED, and 3620 with HCM. The cumulative risk of IE after 10 years was 0.9% in valve disorder, 1.3% in CIED, and 0.5% in HCM patients. Compared with the background population, valve disorder, CIED, and HCM carried a higher associated risk of IE, hazard ratio (HR) = 8.75 [95% confidence interval (CI) 6.36-12.02], HR = 6.63 (95% CI 4.41-9.96), and HR = 6.57 (95% CI 2.33-18.56), respectively. All three study groups were associated with a lower risk of IE compared with high-risk patients, HR = 0.27 (95% CI 0.23-0.32) for valve disorder, HR = 0.28 (95% CI 0.23-0.33) for CIED, and HR = 0.13 (95% CI 0.06-0.29) for HCM.CONCLUSIONS: Heart valve disorder, CIED, and patients with HCM were associated with a higher risk of IE compared with the background population but have a lower associated risk of IE compared with high-risk patients.

AB - AIMS: Stratification of patients at risk of infective endocarditis (IE) remains a cornerstone in guidance of prophylactic strategies of IE. However, little attention has been given to patients considered at moderate risk.METHODS AND RESULTS: Using Danish nationwide registries, we assessed the risk of IE in patients with aortic and mitral valve disorders, a cardiac implantable electronic device (CIED), or hypertrophic cardiomyopathy (HCM) and compared these patient groups with (i) controls from the background population using risk-set matching and (ii) a high-risk population (prosthetic heart valve). Cumulative incidence plots and multivariable adjusted Cox proportional hazard analysis were used to compare risk of IE between risk groups. We identified 83 453 patients with aortic or mitral valve disorder, 50 828 with a CIED, and 3620 with HCM. The cumulative risk of IE after 10 years was 0.9% in valve disorder, 1.3% in CIED, and 0.5% in HCM patients. Compared with the background population, valve disorder, CIED, and HCM carried a higher associated risk of IE, hazard ratio (HR) = 8.75 [95% confidence interval (CI) 6.36-12.02], HR = 6.63 (95% CI 4.41-9.96), and HR = 6.57 (95% CI 2.33-18.56), respectively. All three study groups were associated with a lower risk of IE compared with high-risk patients, HR = 0.27 (95% CI 0.23-0.32) for valve disorder, HR = 0.28 (95% CI 0.23-0.33) for CIED, and HR = 0.13 (95% CI 0.06-0.29) for HCM.CONCLUSIONS: Heart valve disorder, CIED, and patients with HCM were associated with a higher risk of IE compared with the background population but have a lower associated risk of IE compared with high-risk patients.

U2 - 10.1093/eurheartj/ehy629

DO - 10.1093/eurheartj/ehy629

M3 - Journal article

C2 - 30346503

VL - 40

SP - 1355

EP - 1361

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 17

ER -

ID: 234024704

Institut for Klinisk Medicin