An exploratory analysis of clinical and sociodemographic factors in CGRP-induced migraine attacks: A REFORM study
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To investigate whether clinical and sociodemographic factors are associated with calcitonin gene-related peptide (CGRP) induced migraine attacks.
Methods
A total of 139 participants with migraine received a 20-minute intravenous infusion of CGRP (1.5 µg/min) on a single experiment day. The incidence of CGRP-induced migraine attacks was recorded using a headache diary during the 12-hour observational period post-infusion. Univariable and multivariable regression analyses were conducted to examine potential predictors' relationship with CGRP-induced migraine attacks.
Results
CGRP-induced migraine attacks were reported in 110 (79%) of 139 participants. Univariable analysis revealed that participants with cutaneous allodynia had higher odds of developing CGRP-induced migraine attacks, compared with those without allodynia (OR, 2.97, 95% CI, 1.28 to 7.43). The subsequent multivariable analysis confirmed this association (OR, 3.26, 95% CI, 1.32 to 8.69) and also found that participants with migraine with aura had lower odds of developing CGRP-induced migraine attacks (OR, 0.32, 95% CI, 0.12 to 0.84).
Conclusion
Our results suggest that cutaneous allodynia and aura play a role in CGRP-induced migraine attacks, while other clinical and sociodemographic factors do not seem to have any noticeable impact. This indicates that the CGRP provocation model is robust, as the CGRP hypersensitivity remained unaffected despite differences among a heterogeneous migraine population.
Originalsprog | Engelsk |
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Tidsskrift | Cephalalgia |
Vol/bind | 43 |
Udgave nummer | 10 |
Antal sider | 8 |
ISSN | 0333-1024 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study received funding from the Lundbeck Foundation professor grant (R310-2018-3711).
Funding Information:
The authors thank all participating participants, medical students Mohammed Bakir Ahmad Lafta, Sarra Al-Khazali, and Amir Al-Saoudi, headache research laboratory technician Merete Bak Bertelsen, and headache nurse Janne Jensen for their expert assistance. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study received funding from the Lundbeck Foundation professor grant (R310-2018-3711).
Publisher Copyright:
© International Headache Society 2023.
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