Angiotensin converting enzyme inhibition and cerebral circulation--a review

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Angiotensin converting enzyme inhibition and cerebral circulation--a review. / Waldemar, G; Paulson, O B.

I: British Journal of Clinical Pharmacology, Bind 28 Suppl 2, 1989, s. 177S-182S.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Waldemar, G & Paulson, OB 1989, 'Angiotensin converting enzyme inhibition and cerebral circulation--a review', British Journal of Clinical Pharmacology, bind 28 Suppl 2, s. 177S-182S. https://doi.org/10.1111/j.1365-2125.1989.tb03593.x

APA

Waldemar, G., & Paulson, O. B. (1989). Angiotensin converting enzyme inhibition and cerebral circulation--a review. British Journal of Clinical Pharmacology, 28 Suppl 2, 177S-182S. https://doi.org/10.1111/j.1365-2125.1989.tb03593.x

Vancouver

Waldemar G, Paulson OB. Angiotensin converting enzyme inhibition and cerebral circulation--a review. British Journal of Clinical Pharmacology. 1989;28 Suppl 2:177S-182S. https://doi.org/10.1111/j.1365-2125.1989.tb03593.x

Author

Waldemar, G ; Paulson, O B. / Angiotensin converting enzyme inhibition and cerebral circulation--a review. I: British Journal of Clinical Pharmacology. 1989 ; Bind 28 Suppl 2. s. 177S-182S.

Bibtex

@article{bd08ce6f85fd47319ed39bd92f18dea5,
title = "Angiotensin converting enzyme inhibition and cerebral circulation--a review",
abstract = "1. The identification of a vascular wall renin angiotensin system and of angiotensin converting enzyme on the luminal surface of the endothelium in many tissues, including the brain, has stimulated research on the influence of the renin angiotensin system on regional blood flows. 2. In experimental studies inhibition of the angiotensin converting enzyme shifts the limits of cerebral blood flow autoregulation towards lower blood pressure values. 3. In patients with chronic arterial hypertension and in patients with chronic heart failure cerebral blood flow is not changed by acute or chronic angiotensin converting enzyme inhibition, despite in some cases pronounced reductions in the mean arterial blood pressure. Angiotensin converting enzyme inhibition does not change ischaemic regional cerebral blood flow in acute stroke. 4. It is concluded that following angiotensin converting inhibition cerebral blood flow is maintained at an unchanged level. The mechanism may include inhibition of locally produced angiotensin II leading to a selective dilation of larger cerebral arteries with a compensatory constriction of the smaller cerebral arteries.",
keywords = "Angiotensin-Converting Enzyme Inhibitors/pharmacology, Animals, Cerebrovascular Circulation/drug effects, Humans, Rats",
author = "G Waldemar and Paulson, {O B}",
year = "1989",
doi = "10.1111/j.1365-2125.1989.tb03593.x",
language = "English",
volume = "28 Suppl 2",
pages = "177S--182S",
journal = "British Journal of Clinical Pharmacology, Supplement",
issn = "0264-3774",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Angiotensin converting enzyme inhibition and cerebral circulation--a review

AU - Waldemar, G

AU - Paulson, O B

PY - 1989

Y1 - 1989

N2 - 1. The identification of a vascular wall renin angiotensin system and of angiotensin converting enzyme on the luminal surface of the endothelium in many tissues, including the brain, has stimulated research on the influence of the renin angiotensin system on regional blood flows. 2. In experimental studies inhibition of the angiotensin converting enzyme shifts the limits of cerebral blood flow autoregulation towards lower blood pressure values. 3. In patients with chronic arterial hypertension and in patients with chronic heart failure cerebral blood flow is not changed by acute or chronic angiotensin converting enzyme inhibition, despite in some cases pronounced reductions in the mean arterial blood pressure. Angiotensin converting enzyme inhibition does not change ischaemic regional cerebral blood flow in acute stroke. 4. It is concluded that following angiotensin converting inhibition cerebral blood flow is maintained at an unchanged level. The mechanism may include inhibition of locally produced angiotensin II leading to a selective dilation of larger cerebral arteries with a compensatory constriction of the smaller cerebral arteries.

AB - 1. The identification of a vascular wall renin angiotensin system and of angiotensin converting enzyme on the luminal surface of the endothelium in many tissues, including the brain, has stimulated research on the influence of the renin angiotensin system on regional blood flows. 2. In experimental studies inhibition of the angiotensin converting enzyme shifts the limits of cerebral blood flow autoregulation towards lower blood pressure values. 3. In patients with chronic arterial hypertension and in patients with chronic heart failure cerebral blood flow is not changed by acute or chronic angiotensin converting enzyme inhibition, despite in some cases pronounced reductions in the mean arterial blood pressure. Angiotensin converting enzyme inhibition does not change ischaemic regional cerebral blood flow in acute stroke. 4. It is concluded that following angiotensin converting inhibition cerebral blood flow is maintained at an unchanged level. The mechanism may include inhibition of locally produced angiotensin II leading to a selective dilation of larger cerebral arteries with a compensatory constriction of the smaller cerebral arteries.

KW - Angiotensin-Converting Enzyme Inhibitors/pharmacology

KW - Animals

KW - Cerebrovascular Circulation/drug effects

KW - Humans

KW - Rats

U2 - 10.1111/j.1365-2125.1989.tb03593.x

DO - 10.1111/j.1365-2125.1989.tb03593.x

M3 - Review

C2 - 2690908

VL - 28 Suppl 2

SP - 177S-182S

JO - British Journal of Clinical Pharmacology, Supplement

JF - British Journal of Clinical Pharmacology, Supplement

SN - 0264-3774

ER -

ID: 275592379