Association between age at onset of multiple sclerosis and vitamin D level-related factors
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Association between age at onset of multiple sclerosis and vitamin D level-related factors. / Laursen, Julie Hejgaard; Søndergaard, Helle Bach; Sørensen, Per Soelberg; Sellebjerg, Finn; Oturai, Annette Bang.
I: Neurology, Bind 86, Nr. 1, 05.01.2016, s. 88-93.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Association between age at onset of multiple sclerosis and vitamin D level-related factors
AU - Laursen, Julie Hejgaard
AU - Søndergaard, Helle Bach
AU - Sørensen, Per Soelberg
AU - Sellebjerg, Finn
AU - Oturai, Annette Bang
N1 - © 2015 American Academy of Neurology.
PY - 2016/1/5
Y1 - 2016/1/5
N2 - OBJECTIVE: To compare vitamin D level-associated single-nucleotide polymorphisms (SNPs) in GC and CYP2R1, multiple sclerosis (MS) risk SNPs in CYP27B1, CYP24A1, and HLA-DRB1*1501, and adolescent exposure to environmental risk factors for hypovitaminosis D, with MS age at onset.METHODS: This cross-sectional study included 1161 Danish patients with MS; lifestyle questionnaires and blood samples for genotyping were collected from all participants from 2009 to 2012. Information on age at onset was obtained from the Danish MS Treatment Registry. Written informed consent was obtained from all study participants, and the study was approved by the local ethics committee.RESULTS: Younger age at onset was significantly associated with low exposure to summer sun in adolescence, higher body mass index at 20 years of age, and the HLA-DRB1*1501 risk allele in both univariate analyses and in a multivariable regression analysis. No association was found between age at onset and any of the other SNPs or vitamin D-associated environmental factors.CONCLUSION: We demonstrate an independent effect by HLA-DRB1*1501, adolescent summer sun habits, and body mass index at the age of 20 on age at onset of MS.
AB - OBJECTIVE: To compare vitamin D level-associated single-nucleotide polymorphisms (SNPs) in GC and CYP2R1, multiple sclerosis (MS) risk SNPs in CYP27B1, CYP24A1, and HLA-DRB1*1501, and adolescent exposure to environmental risk factors for hypovitaminosis D, with MS age at onset.METHODS: This cross-sectional study included 1161 Danish patients with MS; lifestyle questionnaires and blood samples for genotyping were collected from all participants from 2009 to 2012. Information on age at onset was obtained from the Danish MS Treatment Registry. Written informed consent was obtained from all study participants, and the study was approved by the local ethics committee.RESULTS: Younger age at onset was significantly associated with low exposure to summer sun in adolescence, higher body mass index at 20 years of age, and the HLA-DRB1*1501 risk allele in both univariate analyses and in a multivariable regression analysis. No association was found between age at onset and any of the other SNPs or vitamin D-associated environmental factors.CONCLUSION: We demonstrate an independent effect by HLA-DRB1*1501, adolescent summer sun habits, and body mass index at the age of 20 on age at onset of MS.
KW - Adult
KW - Age of Onset
KW - Cross-Sectional Studies
KW - Female
KW - Genetic Association Studies
KW - HLA-DRB1 Chains
KW - Humans
KW - Life Style
KW - Male
KW - Middle Aged
KW - Multiple Sclerosis
KW - Risk Factors
KW - Sunbathing
KW - Surveys and Questionnaires
KW - Vitamin D
KW - Vitamin D Deficiency
KW - Young Adult
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1212/WNL.0000000000002075
DO - 10.1212/WNL.0000000000002075
M3 - Journal article
C2 - 26446064
VL - 86
SP - 88
EP - 93
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 1
ER -
ID: 179878553