Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis
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Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis. / Cajanus, Antti; Hall, Anette; Koikkalainen, Juha; Solje, Eino; Tolonen, Antti; Urhemaa, Timo; Liu, Yawu; Haanpää, Ramona M; Hartikainen, Päivi; Helisalmi, Seppo; Korhonen, Ville; Rueckert, Daniel; Hasselbalch, Steen; Waldemar, Gunhild; Mecocci, Patrizia; Vanninen, Ritva; van Gils, Mark; Soininen, Hilkka; Lötjönen, Jyrki; Remes, Anne M.
I: Dementia and Geriatric Cognitive Disorders Extra, Bind 8, Nr. 1, 2018, s. 51-59.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis
AU - Cajanus, Antti
AU - Hall, Anette
AU - Koikkalainen, Juha
AU - Solje, Eino
AU - Tolonen, Antti
AU - Urhemaa, Timo
AU - Liu, Yawu
AU - Haanpää, Ramona M
AU - Hartikainen, Päivi
AU - Helisalmi, Seppo
AU - Korhonen, Ville
AU - Rueckert, Daniel
AU - Hasselbalch, Steen
AU - Waldemar, Gunhild
AU - Mecocci, Patrizia
AU - Vanninen, Ritva
AU - van Gils, Mark
AU - Soininen, Hilkka
AU - Lötjönen, Jyrki
AU - Remes, Anne M
PY - 2018
Y1 - 2018
N2 - Aims: We assessed the value of automated MRI quantification methods in the differential diagnosis of behavioral-variant frontotemporal dementia (bvFTD) from Alzheimer disease (AD), Lewy body dementia (LBD), and subjective memory complaints (SMC). We also examined the role of the C9ORF72-related genetic status in the differentiation sensitivity.Methods: The MRI scans of 50 patients with bvFTD (17 C9ORF72 expansion carriers) were analyzed using 6 quantification methods as follows: voxel-based morphometry (VBM), tensor-based morphometry, volumetry (VOL), manifold learning, grading, and white-matter hyperintensities. Each patient was then individually compared to an independent reference group in order to attain diagnostic suggestions.Results: Only VBM and VOL showed utility in correctly identifying bvFTD from our set of data. The overall classification sensitivity of bvFTD with VOL + VBM achieved a total sensitivity of 60%. Using VOL + VBM, 32% were misclassified as having LBD. There was a trend of higher values for classification sensitivity of the C9ORF72 expansion carriers than noncarriers.Conclusion: VOL, VBM, and their combination are effective in differential diagnostics between bvFTD and AD or SMC. However, MRI atrophy profiles for bvFTD and LBD are too similar for a reliable differentiation with the quantification methods tested in this study.
AB - Aims: We assessed the value of automated MRI quantification methods in the differential diagnosis of behavioral-variant frontotemporal dementia (bvFTD) from Alzheimer disease (AD), Lewy body dementia (LBD), and subjective memory complaints (SMC). We also examined the role of the C9ORF72-related genetic status in the differentiation sensitivity.Methods: The MRI scans of 50 patients with bvFTD (17 C9ORF72 expansion carriers) were analyzed using 6 quantification methods as follows: voxel-based morphometry (VBM), tensor-based morphometry, volumetry (VOL), manifold learning, grading, and white-matter hyperintensities. Each patient was then individually compared to an independent reference group in order to attain diagnostic suggestions.Results: Only VBM and VOL showed utility in correctly identifying bvFTD from our set of data. The overall classification sensitivity of bvFTD with VOL + VBM achieved a total sensitivity of 60%. Using VOL + VBM, 32% were misclassified as having LBD. There was a trend of higher values for classification sensitivity of the C9ORF72 expansion carriers than noncarriers.Conclusion: VOL, VBM, and their combination are effective in differential diagnostics between bvFTD and AD or SMC. However, MRI atrophy profiles for bvFTD and LBD are too similar for a reliable differentiation with the quantification methods tested in this study.
U2 - 10.1159/000486849
DO - 10.1159/000486849
M3 - Journal article
C2 - 29606954
VL - 8
SP - 51
EP - 59
JO - Dementia and Geriatric Cognitive Disorders
JF - Dementia and Geriatric Cognitive Disorders
SN - 1420-8008
IS - 1
ER -
ID: 216511881