Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis : an exploratory study. / Blinkenberg, Morten; Mathiesen, Henrik K; Tscherning, Thomas; Jønsson, Agnete; Svarer, Claus; Holm, Søren; Sellebjerg, Finn; Paulson, Olaf B; Hanson, Lars G; Sorensen, Per S.

I: Neurological Research, Bind 34, Nr. 1, 01.2012, s. 52-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Blinkenberg, M, Mathiesen, HK, Tscherning, T, Jønsson, A, Svarer, C, Holm, S, Sellebjerg, F, Paulson, OB, Hanson, LG & Sorensen, PS 2012, 'Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study', Neurological Research, bind 34, nr. 1, s. 52-8. https://doi.org/10.1179/1743132811Y.0000000059

APA

Blinkenberg, M., Mathiesen, H. K., Tscherning, T., Jønsson, A., Svarer, C., Holm, S., Sellebjerg, F., Paulson, O. B., Hanson, L. G., & Sorensen, P. S. (2012). Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study. Neurological Research, 34(1), 52-8. https://doi.org/10.1179/1743132811Y.0000000059

Vancouver

Blinkenberg M, Mathiesen HK, Tscherning T, Jønsson A, Svarer C, Holm S o.a. Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study. Neurological Research. 2012 jan.;34(1):52-8. https://doi.org/10.1179/1743132811Y.0000000059

Author

Blinkenberg, Morten ; Mathiesen, Henrik K ; Tscherning, Thomas ; Jønsson, Agnete ; Svarer, Claus ; Holm, Søren ; Sellebjerg, Finn ; Paulson, Olaf B ; Hanson, Lars G ; Sorensen, Per S. / Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis : an exploratory study. I: Neurological Research. 2012 ; Bind 34, Nr. 1. s. 52-8.

Bibtex

@article{3d6cb99a95664712a9bf12aca6a416e6,
title = "Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study",
abstract = "Positron emission tomography (PET) studies have shown that cortical cerebral metabolic rate of glucose (CMRglc) is reduced in multiple sclerosis (MS). Quantitative magnetic resonance spectroscopy (MRS) measures of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) assess neuronal deterioration, and several studies have shown reductions in MS. Furthermore, both PET and MRS reductions correlate with cognitive dysfunction in MS. Our aim was to determine if changes in cortical CMRglc in early MS correlate with NAA/Cr measurements of neuronal deterioration, as well as cognitive dysfunction and neurological disability.",
author = "Morten Blinkenberg and Mathiesen, {Henrik K} and Thomas Tscherning and Agnete J{\o}nsson and Claus Svarer and S{\o}ren Holm and Finn Sellebjerg and Paulson, {Olaf B} and Hanson, {Lars G} and Sorensen, {Per S}",
year = "2012",
month = jan,
doi = "10.1179/1743132811Y.0000000059",
language = "English",
volume = "34",
pages = "52--8",
journal = "Neurological Research",
issn = "0161-6412",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis

T2 - an exploratory study

AU - Blinkenberg, Morten

AU - Mathiesen, Henrik K

AU - Tscherning, Thomas

AU - Jønsson, Agnete

AU - Svarer, Claus

AU - Holm, Søren

AU - Sellebjerg, Finn

AU - Paulson, Olaf B

AU - Hanson, Lars G

AU - Sorensen, Per S

PY - 2012/1

Y1 - 2012/1

N2 - Positron emission tomography (PET) studies have shown that cortical cerebral metabolic rate of glucose (CMRglc) is reduced in multiple sclerosis (MS). Quantitative magnetic resonance spectroscopy (MRS) measures of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) assess neuronal deterioration, and several studies have shown reductions in MS. Furthermore, both PET and MRS reductions correlate with cognitive dysfunction in MS. Our aim was to determine if changes in cortical CMRglc in early MS correlate with NAA/Cr measurements of neuronal deterioration, as well as cognitive dysfunction and neurological disability.

AB - Positron emission tomography (PET) studies have shown that cortical cerebral metabolic rate of glucose (CMRglc) is reduced in multiple sclerosis (MS). Quantitative magnetic resonance spectroscopy (MRS) measures of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) assess neuronal deterioration, and several studies have shown reductions in MS. Furthermore, both PET and MRS reductions correlate with cognitive dysfunction in MS. Our aim was to determine if changes in cortical CMRglc in early MS correlate with NAA/Cr measurements of neuronal deterioration, as well as cognitive dysfunction and neurological disability.

U2 - 10.1179/1743132811Y.0000000059

DO - 10.1179/1743132811Y.0000000059

M3 - Journal article

VL - 34

SP - 52

EP - 58

JO - Neurological Research

JF - Neurological Research

SN - 0161-6412

IS - 1

ER -

ID: 48525026